|
|
| Line 1: |
Line 1: |
| − | {{Utrecht/Navigation}}
| |
| − | <html>
| |
| | | | |
| − | <style>
| |
| − | .customelementC3{
| |
| − | position: absolute;
| |
| − | font-size: 1.2vw;
| |
| − | text=align: left!important;
| |
| − | z-index: 60;
| |
| − | }
| |
| − | </style>
| |
| − | <body>
| |
| − |
| |
| − | <div class = "customelementM timeline">
| |
| − | <img style = "z-index: 42;position: relative" src="https://static.igem.org/mediawiki/2018/4/4e/T--Utrecht--2018-Graphic2-Home.svg">
| |
| − | <div class="customelementC3" style = "top: 1%;left: 23%;width: 64%;border: 25px solid #A4C2F4;z-index: 5">
| |
| − | <video width = "100%" autoplay>
| |
| − | <source src="https://static.igem.org/mediawiki/2018/b/bb/T--Utrecht--2018--Home-Animation.mp4" type="video/mp4">
| |
| − | Your browser does not support the video tag :(
| |
| − | </video>
| |
| − | </div>
| |
| − | <div class="customelementC3" style = "top: 68.5%;left: 49%;width: 35%;text-align: center;font-size: 1.5vw">
| |
| − | Hello You!
| |
| − | </br></br>
| |
| − | Hello You!
| |
| − |
| |
| − | Welcome to our wiki page. We are Team Utrecht 2018, a very diverse team from Utrecht University in the Netherlands. Want to know more about our team?
| |
| − |
| |
| − | </br></br>
| |
| − | <a href = "https://2018.igem.org/Team:Utrecht/Team"> Click Here. </a>
| |
| − |
| |
| − | </div>
| |
| − |
| |
| − | </div>
| |
| − | <div class = "customelementM transparent timeline">
| |
| − | <img src="https://static.igem.org/mediawiki/2018/5/52/T--Utrecht--2018-Graphic-Home.svg">
| |
| − |
| |
| − | <div class="customelementC3" style = "top: 3.4%;left: 19%;width: 30%;">
| |
| − | Water is arguably our most precious resource.
| |
| − | Unfortunately, increased use of pharmaceuticals including antidepressants and chemotherapeutic medications are contaminating this valuable resource.
| |
| − | </div>
| |
| − |
| |
| − |
| |
| − | <div class="customelementC3" style = "top: 13.9%;left: 27.4%;width: 43%;">
| |
| − | After human use of these medications, remnants are disposed through the sewage systems and eventually contaminate surface waters, resulting in an increased pollutant concentration in the environment.
| |
| − | </div>
| |
| − |
| |
| − |
| |
| − | <div class="customelementC3" style = "top: 27.4%;left: 12%;width: 37%;">
| |
| − | These pharmaceutical waste products are still biologically active in vertebrates. For example, even low concentrations of antidepressants pose a threat to both society and ecological systems.
| |
| − | </div>
| |
| − |
| |
| − | <div class="customelementC3" style = "top: 28.8%;left: 59.2%;width: 26%;">
| |
| − |
| |
| − | We talked to water treatment companies, specialists and other stakeholders about how to improve current detection methods. Key requirements for our biosensor included safety, accuracy, high measurement rates and low costs.
| |
| − |
| |
| − | See more on <a href = "https://2018.igem.org/Team:Utrecht/Human_Practices"> Integrated Human Practices.</a>
| |
| − | </div>
| |
| − |
| |
| − | <div class="customelementC3" style = "top: 36.1%;left: 20%;width: 41%;">
| |
| − | Based on the input of experts and stakeholders, we developed the DeTaXion biosensor. DeTaXion improves identification of antidepressants in water, based on the chemotaxis pathway of E. coli.
| |
| − |
| |
| − | For a more detailed discussion you can visit our <a href = "https://2018.igem.org/Team:Utrecht/Description"> Project Description.</a>
| |
| − | </div>
| |
| − |
| |
| − | <div class="customelementC3" style = "top: 47.2%;left: 4.6%;width: 44%;">
| |
| − | The chemotaxis pathway was adjusted in such a manner that E. coli can detect antidepressants. Upon recognition of the antidepressant agents, the light signal produced by the E. coli changes.
| |
| − | </div>
| |
| − |
| |
| − | <div class="customelementC3" style = "top: 52.6%;left: 65.6%;width: 26%;">
| |
| − | To achieve the detection of antidepressants, we set up a three step approach <a href = "https://2018.igem.org/Team:Utrecht/Design"> Project Design</a>.
| |
| − | </br></br>
| |
| − | Next, we performed these steps in the lab, which resulted into interesting <a href = "https://2018.igem.org/Team:Utrecht/Results">Findings</a>.
| |
| − | </div>
| |
| − |
| |
| − | <div class="customelementC3" style = "top: 65.2%;left: 56%;width: 32%;">
| |
| − | Since we wanted to enlighten others about biotechnology, water safety and valorisation, we engaged the public at several outreach event, including our <a href = "https://2018.igem.org/Team:Utrecht/Conference"> biotechnology conference </a> and “Weekend of Science”, establishing an open discussion. More about this topic can be found in <a href = "https://2018.igem.org/Team:Utrecht/Public_Engagement">Public Engagement</a>.
| |
| − | </br></br>
| |
| − | Furthermore, we <a href = "https://2018.igem.org/Team:Utrecht/Collaborations">collaborated</a> with other iGEM teams to get valuable insights.</div>
| |
| − |
| |
| − | <div class="customelementC3" style = "top: 76.1%;left: 34%;width: 30%;">
| |
| − | We also had to find the means to fund our project.
| |
| − |
| |
| − | Luckily, some parties were willing to invest
| |
| − | their time and capital in us.
| |
| − | </br></br></br>
| |
| − | We are very grateful to our <a href = "https://2018.igem.org/Team:Utrecht/Sponsors">Sponsors</a> and other <a href = "https://2018.igem.org/Team:Utrecht/Attributions">Contributors</a>.
| |
| − | A special thank you for your help!
| |
| − | </div>
| |
| − |
| |
| − | <div class="customelementC3" style = "top: 88%;left: 54%;width: 38%">
| |
| − | After a lot of late nights, long hours in the laboratory, insightful conversations with stakeholders, sweat (maybe some tears) and a massive amount of laughter and joy.
| |
| − | </br></br>
| |
| − | We, Team Utrecht 2018, proudly present you our applied product:
| |
| − | </br></br>
| |
| − | <a href = "https://2018.igem.org/Team:Utrecht/Applied_Design"><i style = "font-size: 1.6vw"><u><b>DeTaXion</a>: A biosensor to rapidly identify harmful water-based pharmaceuticals in surface waters.</i>
| |
| − |
| |
| − | </div>
| |
| − | </div>
| |
| − |
| |
| − | </body>
| |
| − |
| |
| − | </html>
| |
| − |
| |
| − | {{Utrecht/Footer}}
| |
