Difference between revisions of "Team:TecMonterrey GDL/Description"

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        $('.arrow').click(function(event){
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            switch(event.target.id){
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                break;
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            <canvas id="lactobachill-bg"></canvas>
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        </div>
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        <div class="col-12 text-center">
 +
            <h2 class="purple-color title">A smart psychobiotic with anxiolytic and antidepressant properties</h2>
 +
        </div>
 +
    </div>
 +
    <div class="row">
 +
        <div class="col-md-5">
 +
            <div class="row">
 +
                <div class="col-8 text-center">
 +
                    <img class="microbes-img" src="./psychotropic.png" alt="probiotics picture">
 +
                    <h3 class="subtitle blue-color">Psychotropic</h3>
 +
                    <p class="text blue-color">Substance that has an effect on people’s state of mind.</p>
 +
                </div>
 +
                <div class="col-4 text-center">
 +
                    <span class="symbol blue-color">+</span>
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                </div>
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            </div>
 +
        </div>
 +
        <div class="col-md-4">
 +
            <div class="row">
 +
                <div class="col-8 text-center">
 +
                    <img class="microbes-img" src="./probiotics.png" alt="probiotics picture">
 +
                    <h3 class="subtitle violet-color">Probiotics</h3>
 +
                    <p class="text violet-color">A microorganism that when consumed maintains or restores beneficial bacteria to the digestive tract.</p>
 +
                </div>
 +
                <div class="col-4 text-center">
 +
                    <span class="symbol blue-color">=</span>
 +
                </div>
 +
            </div>
 +
        </div>
 +
        <div class="col-md-3 text-center">
 +
            <img class="microbes-img" src="./psychobiotics.png" alt="probiotics picture">
 +
            <h3 class="subtitle aqua-color">Psychobiotics</h3>
 +
            <p class="text aqua-color">Gut microbiomes may have a significant impact on mood and cognition</p>
 +
        </div>
 +
    </div>
 +
    <div class="text-center">
 +
        <div class="arrow bounce" id="arrow1"></div>
 +
    </div>
 +
</div>
 +
<div class="container" id="page2">
 +
    <div class="row">
 +
        <div class="col-12 text-center">
 +
            <h2 class="desc-title lightblue-color">Description</h2>
 +
        </div>
 +
        <div class="col-12 paragraphs">
 +
            <p>The microbiota has been consistently linked to human well-being. Studies show that microbiota not only can impact nutrition and metabolism, but also the mood.</p>
 +
            <p>Psychobiotics is the field where probiotics and psychotropics (molecules that can alter mood) converge, opening the possibility of therapies where good bacteria can help lighten or reduce the impact of certain psychiatric conditions, such as depression. </p>
 +
            <p>Depression affects more than 300 million people in the world, shockingly, an increase of more than 18% between 2005 and 2015 was observed according to World Health Organization (2018). There are many barriers towards dealing with depression, from availability of help to non-recognition of the problem. </p>
 +
            <p>Depression is the leading cause of ill health and disability worldwide. Our Human Practices are centered towards conscientization and against stigmatization of depression; as well as performing a campaign to incentive people to seek aid when they need to.</p>
 +
 +
        </div>
 +
    </div>
 +
    <div class="text-center">
 +
        <div class="arrow bounce" id="arrow2"></div>
 +
    </div>
 +
</div>
 +
<div class="container" id="page3">
 +
        <div class="row third-page">
 +
            <div class="col-md-6 paragraphs">
 +
                <p>On the other hand, there is a strong relationship between systemic inflammation and psychiatric disorders.</p>
 +
                <p>Our strategy consists of genetically engineering Lactobacillus rhamnosus GG,  a natural gut probiotic, into producing and possible secreting soluble IL-6 receptors gp80 (mutated for increased affinity) and gp130 in order to aid reducing trans-signalization of the inflammatory pathway of cytokine interleukin 6.</p>
 +
                <p>Our system will be triggered by nitrosative stress, which is a known pathway of inflammatory, depressive and stress afflictions.</p>
 +
                <p>Blocking the trans-signaling of IL-6 system also prevents tryptophan catabolism to serotonin to deviate into other catabolites.</p>
 +
                <p>This is how Lactobachill, can be used as an alternative treatment for depression as well as other inflammatory disorders.</p>
 +
            </div>
 +
            <div class="col-md-6 text-center d-flex align-items-center">
 +
                <img class="process-img" src="https://static.igem.org/mediawiki/2018/4/4d/T--TecMonterrey_GDL--Description--process.png" alt="process image">
 +
            </div>
 +
        </div>
 +
    </div>
 +
 +
</html>

Revision as of 01:55, 11 July 2018

A smart psychobiotic with anxiolytic and antidepressant properties

probiotics picture

Psychotropic

Substance that has an effect on people’s state of mind.

+
probiotics picture

Probiotics

A microorganism that when consumed maintains or restores beneficial bacteria to the digestive tract.

=
probiotics picture

Psychobiotics

Gut microbiomes may have a significant impact on mood and cognition

Description

The microbiota has been consistently linked to human well-being. Studies show that microbiota not only can impact nutrition and metabolism, but also the mood.

Psychobiotics is the field where probiotics and psychotropics (molecules that can alter mood) converge, opening the possibility of therapies where good bacteria can help lighten or reduce the impact of certain psychiatric conditions, such as depression.

Depression affects more than 300 million people in the world, shockingly, an increase of more than 18% between 2005 and 2015 was observed according to World Health Organization (2018). There are many barriers towards dealing with depression, from availability of help to non-recognition of the problem.

Depression is the leading cause of ill health and disability worldwide. Our Human Practices are centered towards conscientization and against stigmatization of depression; as well as performing a campaign to incentive people to seek aid when they need to.

On the other hand, there is a strong relationship between systemic inflammation and psychiatric disorders.

Our strategy consists of genetically engineering Lactobacillus rhamnosus GG, a natural gut probiotic, into producing and possible secreting soluble IL-6 receptors gp80 (mutated for increased affinity) and gp130 in order to aid reducing trans-signalization of the inflammatory pathway of cytokine interleukin 6.

Our system will be triggered by nitrosative stress, which is a known pathway of inflammatory, depressive and stress afflictions.

Blocking the trans-signaling of IL-6 system also prevents tryptophan catabolism to serotonin to deviate into other catabolites.

This is how Lactobachill, can be used as an alternative treatment for depression as well as other inflammatory disorders.

process image