Team:H14Z1 Hangzhou/Applied Design
Applied Design
Smart yogurt
Glutathione (GSH) and S-adenosyl methionine (SAM) have been applied to prevent and treat a variety of liver diseases. Due to low stability and short half-life, oral table supply of GSH or SAM might be replaced by supplying these molecules in-vivo using our smart yogurt strategy. In the experiment, two-functional GSH synthetase gene (gshF) and SAM synthetase gene (metK) were in tandem inserted into the expression vector (pNZ8148), and the resulted plasmid (pNZ-GM) was further employed to construct the target vector pNZ-GMcA by introducing adhesion factor gene (cwaA). This combinatory vector was transformed into food-grade Lactococcus lactis NZ9000 for their functional expressions. The results showed that our smart yogurts not only have much higher contents of SAM and GSH with regard to commercial yogurts in the daily life, but also hold high-density of colonization-prone cells which will produce these two liver-protective factors continuously in our gastrointestinal tracts.
Best Applied Design Special Prize
This is a prize for the team that has developed a synbio product to solve a real world problem in the most elegant way. The students will have considered how well the product addresses the problem versus other potential solutions, how the product integrates or disrupts other products and processes, and how its lifecycle can more broadly impact our lives and environments in positive and negative ways.
To compete for the Best Applied Design prize, please describe your work on this page and also fill out the description on the judging form.
You must also delete the message box on the top of this page to be eligible for this prize.
Inspiration
Take a look at what some teams accomplished for this prize.