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Project

Welcome to CO-RAD!

       The complexity of genetic circuits has made it difficult for synthetic biologists to design the artificial
       biological systems. In our project, we developed CO-RAD, a Collaborative
           Optimization platform with multiple functions including Recommendation,
           Analysis and Design. With the help of CO-RAD, users can design genetic circuits easily and cooperate
       with remote partners in real time.
       More importantly, the search & recommendation system in CO-RAD were developed to
       inspire users with some previous projects and optimize their design with evolutionary
           algorithm. Moreover,  <a href="javascript:void(0)" goto="Simulation-Circuits"> a
               novel numerical simulation algorithm </a> 
       for circuit）applied in CO-RAD was developed to predict the expression level of genetic circuits in no time.
       Through in addition, we incorporated self-designed  <a href="javascript:void(0)" goto="Validation">
               wet-lab validation </a> into
       our project to validate the new results designed by our CO-RAD platform. In conclusion, by assisting in
       collaboration and inspiration, CO-RAD makes complex biological systems accessible to researchers who want
       rapid, intuitive, and high-quality
       accomplish their designs. Click here to design in <a href="http://www.sysu-corad.com/">CO-RAD</a> way.

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Background

       The data shows a shift from single-investigator 'little science' to increasingly large, expensive,
       multinational, interdisciplinary and interdependent 'big science'. The scientific collaboration among
       researchers becomes more pervasive and essential.

       To synthetic biology, due to the natural complexity of biological systems, genetic circuit design and the
       limited personal experience, it is very difficult for individuals to design a viable circuit alone, raising the
       demand of effective collaboration methods. Interdisciplinary and engineering-oriented natures on scientific
       research make it praticularly open to collaboration, while time and space issues would compromise the
       convenience and the efficency to conduct a collaboration.

       In this case, we developed a software to improve the efficiency in collaboration and help inspire
       synbiologists' ideas, assisting in designing and optimizing their design.

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Figure 1: Percentage of multientity publications, 2000–2009

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Figure 2: The percentage of multiinstitutional publications in 22 ESI fields

       Therefore, we're here to solve the following problems:

1. How to make tele-cooperation as convenient as face-to-face collaboration?
2. How to encourage users to think of and share more creative ideas while cooperating?

Solution

Help users come up with more creative ideas

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Search & recommendation

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Analysis & simulation

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Guide the design

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Search & recommendaion

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               Given the experience of previous achievements provides valuable inspiration while cooperating, we
               developed this function to help users quickly find the project they need.

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Analysis & simulation

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               Deeper understanding of the circuit design can help users make more hypothetical opinions. Our software
               analyzes circuits and gives values for CG and CAI, and builds mathematical simulation models to predict
               expression levels.

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Guide the design

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               Through an algorithm that simulates evolution, users can get optimal kinetic parameters for circuits,
               which can assist users in modifying their circuits to reach the expected behavior.

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Solve the inconvenience of remote collaboration and communication

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Real-time collaboration

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Synchronization sketchpad

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SBOL support

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Real-time collaboration

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               A real-time genetic circuit design platform where multiple users can edit one file at the same time,
               just like (and even better than!) working on the same computer.

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Synchronization sketchpad

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               A tool that simulates pen and paper, users can express their opinions by labeling or drawing during the
               communication process.

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SBOL support

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               Our system is compatible with SBOL, the most common data format in the field of synthetic biology,
               which means circuits edited on other software can be quickly imported into our software without
               re-editing.

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