Team:Tec-Monterrey/sandbox
Home
DNA has been called an excellent medium
for archiving data, interpreting the four base
pairs as a new language.
iGEM Tec-Monterrey 2018 attempts to create
a new system, which saves information regarding
its surroundings.
Through gene induction,
bacteria could store
external information in their DNA.
Information storage in DNA has
been demonstrated by recent efforts,
saving anything
from messages to animations.
Through gene induction,
bacteria could store
external information in their DNA.
Translating an input from its surroundings,
to an encoded DNA output
E. coding
Tec-Monterrey
References
[1] Díez-Villaseñor, C., Guzmán, N. M., Almendros, C., García-Martínez, J. & Mojica, F. J. M. CRISPR-spacer integration reporter plasmids reveal distinct genuine acquisition specificities among CRISPR-Cas I-E variants of Escherichia coli. RNA Biol. (2013). doi:10.4161/rna.24023
[2] Farzadfard, F., & Lu, T. K. Genomically encoded analog memory with precise in vivo DNA writing in living cell populations. Science. (2014). doi: 10.1126/science.1256272
[3] Levy, A., Goren, M. G., Yosef, I., Auster, O., Manor, M., Amitai, G., Edgar, R., Qimron, U. & Sorek, R. CRISPR adaptation biases explain preference for acquisition of foreign DNA. Nature. (2015). doi:10.1038/nature14302
[4] Nuñez, J. K. Mechanism of CRISPR–Cas Immunological Memory. (2016). Doctoral dissertation, UC Berkeley.
[5] Nuñez, J. K., Kranzusch P, Noeske J, Wright A, Davies C, Doudna J. Cas1-Cas2 complex formation mediates spacer acquisition during CRISPR-Cas adaptive immunity. Nat. Struct. Mol. Biol. (2014). doi:10.1038/nsmb.2820
[6] Shipman, S. L., Nivala, J., Macklis, J. D., & Church, G. M. Molecular recordings by directed CRISPR spacer acquisition. Science.(2016). doi: 10.1126/science.aaf1175