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Safety

Dry-lab Safety

Q: In biosafety, what items should we pay attention to?

   A: The following two principles should be concerned. Firstly, choose a safe chassis for all your circuits.
   Secondly, only safe parts are available for your design. For more information, please refer to the GEM safety
   community announced <a href="https://2018.igem.org/Safety/White_List">2018 White List</a>.

Q: What about the safety level of your parts in CO-RAD?

   A: Parts safety levels are seriously evaluated based on their original and applied chassis information.
   Specifically, we rid parts in Risk Group 3 & 4, and graded the rest parts into 3 safety level according to the
   following principles:

• 1 level: no "Red Flag" tag, belonging Chassis belongs to Risk Group 1.
• 2 level: no "Red Flag" tag, belonging Chassis belongs to Risk Group 2.
• 3 level: with "Red Flag" tag.

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Figure 2: Safety group distribution

Q: Can safety be ganranteed when we use the parts?

   A: Most parts in our database is in Risk 1, which can be used without any concerns, while parts in Risk 2 & 3 may
   lead to potential danger. To guarantee the safety of your design, CO-RAD will automatically display the safety
   level of parts when referred. Green, yellow, red represents Risk 1, 2, 3 respectively.

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Figure 3: Warning of dangerous parts

Q: How can users suggest the potential safety issues of others' circuit design?

A:

1. We attach importance to efficient collabaration in finding potential safety issues. Via comments, users can alert their partners in time. (Figure 4)

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Figure 4: Comment on the design
2. Meanwhile, in order to prevent users from using dangerous chassis by mistake, users need to select chassis before sharing their circuits, and other users can view its information. (Figure 5)

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Figure 5: Select chassis