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Clostridium difficile infection is the most common cause of antibiotic-associated diarrhoea in the Western World and is a big problem in hospitals and care-facilities.
A consequence of antibiotic misuse and the capability of bacteria to readily evolve has allowed antibiotic resistance to become a worldwide major dilemma.
The goal of our project is to engineer a phage which will infect C. difficile and express genetic constructs designed to suppress toxin production.
What is C. difficile infection?
What is the problem?
What are we going to do?
