Team:Tec-Monterrey/sandbox
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DNA has been called an excellent medium
for archiving data, interpreting the four base
pairs as a new language.
Through gene induction,
bacteria could store
external information in their DNA.
iGEM Tec-Monterrey 2018 attempts to create
a new system, which saves information regarding
its surroundings.
Information storage in DNA has
been demonstrated by recent efforts,
saving anything
from messages to animations.
E. coding
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Tec-Monterrey
Storing the world one base at a time
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DRAG AND DROP!
Pb
NO3
PO4
As
References
[1] Díez-Villaseñor, C., Guzmán, N. M., Almendros, C., García-Martínez, J. & Mojica, F. J. M. CRISPR-spacer integration reporter plasmids reveal distinct genuine acquisition specificities among CRISPR-Cas I-E variants of Escherichia coli. RNA Biol. (2013). doi:10.4161/rna.24023
[2] Farzadfard, F., & Lu, T. K. Genomically encoded analog memory with precise in vivo DNA writing in living cell populations. Science. (2014). doi: 10.1126/science.1256272
[3] Levy, A., Goren, M. G., Yosef, I., Auster, O., Manor, M., Amitai, G., Edgar, R., Qimron, U. & Sorek, R. CRISPR adaptation biases explain preference for acquisition of foreign DNA. Nature. (2015). doi:10.1038/nature14302
[4] Nuñez, J. K. Mechanism of CRISPR–Cas Immunological Memory. (2016). Doctoral dissertation, UC Berkeley.
[5] Nuñez, J. K., Kranzusch P, Noeske J, Wright A, Davies C, Doudna J. Cas1-Cas2 complex formation mediates spacer acquisition during CRISPR-Cas adaptive immunity. Nat. Struct. Mol. Biol. (2014). doi:10.1038/nsmb.2820
[6] Shipman, S. L., Nivala, J., Macklis, J. D., & Church, G. M. Molecular recordings by directed CRISPR spacer acquisition. Science.(2016). doi: 10.1126/science.aaf1175