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Can Cells be Controlled with Sound?C ells be Activated with Sound?
T oda y , it is r outine to induce the e xp r ession o f a gene in E . coli using only a small molecule . R e al small . T hink a r abinose , lactose , and rhamnose . P ouring th r ough p r evious r es e a r ch , we’ve determined th a t di r ected soundwaves can st r ess a cell ’ s pumps to open . La r ge enough for our ‘ e xp r ession inducing’ molecules to pass inside the cell‘s walls . One may ask , can sound become a r outine m e ans to induce gene e xp r ession in enginee r ed E . coli? While Sloveni a ’ s Sonicell and SUS T ech ’ s C e arll ’ s Sec r et p r ojects pursued a similar question in mammalian cells . We focused on inducing E. coli to express chromogenic reporters. . In other words , we’ve caused ta r geted cells to change colors by b e aming sound a t them . T oda y , it is r outine to induce the e xp r ession o f a gene in E . coli using only a small molecule . R e al small . T hink a r abinose , lactose , and rhamnose . P ouring th r ough p r evious r es e a r ch , we’ve determined th a t di r ected soundwaves can st r ess a cell ’ s pumps to open . La r ge enough for our ‘ e xp r ession inducing’ molecules to pass inside the cell‘s walls . One may ask , can sound become a r outine m e ans to induce gene e xp r ession in enginee r ed E . coli? While Sloveni a ’ s Sonicell and SUS T ech ’ s C e arll ’ s Sec r et p r ojects pursued a similar question in mammalian cells , we’ r e studying the details o f both p r ojects to induce ch r omogenesis in enginee r ed E. C oli cells . In English , we’ve caused ta r geted cells to change colors by b e aming sound a t them .
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