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Revision as of 14:50, 21 September 2018
MOSFET
Description
MOSFET (metal-oxide-semiconductor field-effect transistor) is an essential component in both analog and digital circuits such as analog switches and micro-processors. Inspired by this idea, we built genetic circuit "MOSFETs" in animal T cells which is "Monitoring and Operating System Founded on Engineered T cells". The upstream of this genetic circuit uses synNotch to transduce extracellular signals into cells. The concentration of signals corresponds to different threshold values, and the system can respond accordingly under different concentrations. We achieved some level of logical effects by applying recombinase's reverse mechanism to ensure the uniqueness of downstream output. By using ODE and gillespie algorithms, we conducted validations on mathematical models. Using the concentration of cell surface antigen as gate signal, different recombinase and promoter to adjust threshold value, we conducted experiment validation to measure different promoters and recombinases' response to signals.
Before you start
Please read the following pages:
Styling your wiki
You may style this page as you like or you can simply leave the style as it is. You can easily keep the styling and edit the content of these default wiki pages with your project information and completely fulfill the requirement to document your project.
While you may not win Best Wiki with this styling, your team is still eligible for all other awards. This default wiki meets the requirements, it improves navigability and ease of use for visitors, and you should not feel it is necessary to style beyond what has been provided.
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When you upload, set the "Destination Filename" to T--YourOfficialTeamName--NameOfFile.jpg. (If you don't do this, someone else might upload a different file with the same "Destination Filename", and your file would be erased!)
Wiki template information
We have created these wiki template pages to help you get started and to help you think about how your team will be evaluated. You can find a list of all the pages tied to awards here at the Pages for awards link. You must edit these pages to be evaluated for medals and awards, but ultimately the design, layout, style and all other elements of your team wiki is up to you!
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On this page you can document your project, introduce your team members, document your progress and share your iGEM experience with the rest of the world!
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Tips
This wiki will be your team’s first interaction with the rest of the world, so here are a few tips to help you get started:
- State your accomplishments! Tell people what you have achieved from the start.
- Be clear about what you are doing and how you plan to do this.
- You have a global audience! Consider the different backgrounds that your users come from.
- Make sure information is easy to find; nothing should be more than 3 clicks away.
- Avoid using very small fonts and low contrast colors; information should be easy to read.
- Start documenting your project as early as possible; don’t leave anything to the last minute before the Wiki Freeze. For a complete list of deadlines visit the iGEM 2018 calendar
- Have lots of fun!
Inspiration
You can also view other team wikis for inspiration! Here are some examples: