Difference between revisions of "Team:Paris Bettencourt/Optimization"

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Revision as of 23:45, 17 October 2018

Optimization

Based on the results of the Testing and Modeling groups, we arrived at the following simple model for how StarCores function.

Box 1: Why are StarCore Proteins Difficult to Express?

Based on the results of the Testing and Modeling groups, we arrived at the following simple model for how StarCores function.


  • StarCores act by destabilizing the bacterial membrane, similar to conventional AMPs.


  • StarCore activity is mediated by a nonspecific mechanism, probably charge.

  • AMP-Core fusions are difficult to express, probably because the do not fold well.

    		•
    Centre for Research and Interdisciplinarity (CRI)
    Faculty of Medicine Cochin Port-Royal, South wing, 2nd floor
    Paris Descartes University
    24, rue du Faubourg Saint Jacques
    75014 Paris, France
    paris-bettencourt-2018@cri-paris.org