Difference between revisions of "Team:DLUT China B"

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{{DLUT_China_B}}
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<head>
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    <title>2018 iGEM_DLUT_B</title>
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<body onload="check()">
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<div id="dlutb">
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    <div id="header">
 +
        <div id="team">DLUT_China_B</div>
 +
        <div id="nav"></div>
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        <div id="box">
 +
            <img src="https://static.igem.org/mediawiki/2018/4/47/T--DLUT_China_B--Top1.png">
 +
            <div>
 +
                <h2>Dr. Familict</h2>
 +
                <p>Hello! I’m a lovely Kidney baby, an essential organ in your body. Can you see those sparkling items
 +
                    pointed by my hand? Right! This is a wonderful liquid crystal show caused by the combination of
 +
                    β<sub>2</sub>-MG and nanobodies. What’s more, the different concentrations of β<sub>2</sub>-MG make
 +
                    the different degree of brightness showed by liquid crystal. We can make use of this phenomenon to
 +
                    achieve early detection of CKD caused mostly by diabetes and high blood pressure according to the
 +
                    brightness displayed by the detector confidently. Such an amazing idea, right?</p>
 +
            </div>
 +
        </div>
 +
        <br>
 +
    </div>
  
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    <div id="circle">
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        <div class="tr">
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                <a href="https://2018.igem.org/Team:DLUT_China_B/Description">
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                    <img src="https://static.igem.org/mediawiki/2018/b/b8/T--DLUT_China_B--Circle1.png" width="250">
 +
                    <div>Project</div>
 +
                </a>
 +
            </div>
 +
            <div class="td">
 +
                <a href="https://2018.igem.org/Team:DLUT_China_B/Parts">
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                    <img src="https://static.igem.org/mediawiki/2018/f/f0/T--DLUT_China_B--Circle2.png" width="250">
 +
                    <div>Parts</div>
 +
                </a>
 +
            </div>
 +
            <div class="td">
 +
                <a href="https://2018.igem.org/Team:DLUT_China_B/GrayValueConcentrationModel">
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                    <img src="https://static.igem.org/mediawiki/2018/c/c6/T--DLUT_China_B--Circle3.png" width="250">
 +
                    <div>Model</div>
 +
                </a>
 +
            </div>
 +
        </div>
 +
        <div class="tr">
 +
            <div class="td">
 +
                <a href="https://2018.igem.org/Team:DLUT_China_B/Applied_Design">
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                    <img src="https://static.igem.org/mediawiki/2018/7/71/T--DLUT_China_B--Circle4.png" width="250">
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                    <div>Awards</div>
 +
                </a>
 +
            </div>
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            <div class="td">
 +
                <a href="https://2018.igem.org/Team:DLUT_China_B/Human_Practices">
 +
                    <img src="https://static.igem.org/mediawiki/2018/6/63/T--DLUT_China_B--Circle5.png" width="250">
 +
                    <div id="humanPracticesCircle"><p>Human<br>Practices</p></div>
 +
                </a>
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            </div>
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            <div class="td">
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                <a href="https://2018.igem.org/Team:DLUT_China_B/TeamMembers">
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                    <div>Team</div>
 +
                </a>
 +
            </div>
 +
        </div>
 +
    </div>
  
 +
    <div>
 +
        <h2 class="title">Click bubbles to chat with me</h2>
 +
        <div id="chatBubbles"></div>
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    </div>
  
<div class="column" >
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    <div id="footer">
<h1> Welcome to wiki page for 2018 DLUT China B </h1>
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        <div id="address">
<p>This page is under construction at the moment.</p>
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            <h3><i class="fas fa-map-marker-alt"></i> Address</h3>
 +
            <p>No.2 Linggong Road, Ganjingzi District, Dalian City, Liaoning Province, P.R.C., 116024</p>
 +
            <h3><i class="fas fa-at"></i> E-mail</h3>
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            <p>igem_dlut_china_B#163.com (Please replace # with @)</p>
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            <h3>Follow Us</h3>
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    <script src="https://2018.igem.org/wiki/index.php?title=Template:DLUT_China_B/js/script.js&action=raw&ctype=text/javascript"></script>
<h3>Description</h3>
+
    <script>
<br>
+
        /*对话气泡*/
<h4>We are concerned about the world's largest potential group of chronic kidney disease.</h4>
+
        let conversation = {
<p>According to statistics of the World Health Organization, about 1.2 million people died of kidney disease in 2015 worldwide, which is 32% higher than that in 2005. Among them, diabetes and hypertensive patients are the largest potential victims of chronic kidney disease. Of the new ESRD patients in the United States in the past 10 years, 58% are from diabetes and hypertension patients. If we do not intervene in patients with early-stage hypertension or diabetes, it will cause a dramatic deterioration of renal function with a mortality rate up to 90%. However, if the patient's kidney status can be monitored at any time, with early detection and timely medical treatment, up to 70% of the disease may be reversed. Therefore, it is of great social significance to monitor the renal status of patients with early-stage hypertension and diabetes.</p>
+
            ice: {
<p>At this stage, the excretion rate of urinary microalbumin (mALB) is mainly used to diagnose diabetic nephropathy and hypertensive nephropathy. Although the detection method is relatively perfect, it has the following disadvantages:</p>
+
                says: ["Hey, friend! Long time no see! You can click bubbles to chat with me."],
<ol>
+
                reply: [
    <li>The accuracy and specificity of mALB in diagnosing DN are not high, and urinary tract infection and other factors can increase the excretion rate of urinary albumin, resulting in high misdiagnosis and missed diagnosis.</li>
+
                    {
    <li>When the mALB is abnormal, DN has progressed to Phase III. It is not sufficient to use this indicator to monitor the occurrence and development of DN.</li>
+
                        question: "mmm O (* ̄▽ ̄*) O. Long time no see.",
    <li>Renal impairment in hypertension occurs first in the renal tubules, and then in the glomerulus. Urine microalbumin mainly reflects glomerular filtration impairment and is not sensitive to renal tubular injury.</li>
+
                        answer: "ice1"
</ol>
+
                    }
<br>
+
                ]
<h4>We use β<sub>2</sub>M for high sensitivity monitoring of the kidneys.</h4>
+
            },
<p>In order to solve the problems in the above detection methods, we conducted a multi-study investigation to find a new type of indicator β<sub>2</sub>M which has higher sensitivity to early kidney damage. β<sub>2</sub>M is a small molecule globulin produced by lymphocytes, platelets, and polymorphonuclear leukocytes. It can be freely filtered from the glomerulus and is absorbed by the proximal tubular in 99.9% . Under normal condition, the excretion of β<sub>2</sub>M in urine(U-β<sub>2</sub>M) is very small which is no more than 0.25mg/L. U-β<sub>2</sub>M excretion is increased in early urine of diabetic patients with stage I hypertension and diabetes. With the deepening of the renal damage, β<sub>2</sub>M accumulates in patients and continue increase. Therefore, the detection of U-β<sub>2</sub>M in patients with a risk of kidney disease, such as diabetes and hypertension, can achieve real-time monitoring of the condition of the kidneys, as well as the discovery of early nephropathy to prevent irreversible damage to the kidneys.</p>
+
            "ice1": {
<br>
+
                says: [
<h4>What kind of a work we want to complete?</h4>
+
                    "We have a lot of significant updates.(Of course we cannot make it as cool as  the Apple launch update)",
<p>Patients with diabetes for about 5 years or those with Hypertension for 5 to 10 years are at high risk of chronic kidney disease and are at risk of renal impairment at any time. Since diabetics and hypertensives are usually treated at home in early stages , routine blood and urine tests are rarely performed and the U-β<sub>2</sub>M indicator is unknown. This has led many patients to miss the opportunity for early intervention and control. Our work enables these patients to easily monitor their own renal function status at home through the U-β<sub>2</sub>M test. In addition, we can use mobile devices to conduct a brief analysis of the patient's renal function and give medical advice.</p>
+
                    "As an old friend, let me open the VIP channel for you.",
<br>
+
                    'Click "Skip", then you will skip the Project Introduction section.',
<h4>For U-β<sub>2</sub>M we developed a suitable detection method</h4>
+
                    'Click "Listen", then you will acknowledge more details about our story.'
<p>In this project, we combined strongly specific nanobodies with high-sensitivity liquid crystal detection to develop a visual detection method, thereby enabling accurate quantification or semiquantification of microgram-levelU- β<sub>2</sub>M. Firstly, we use nanobody to specifically bind to β<sub>2</sub>M. Compared with conventional antibodies, nanobody is a smaller molecular,less susceptible to denaturation, but still has intact antigen binding properties. In addition, nanobodies can be expressed by <i>E. coli</i> , which make the cost of production is greatly reduced. What's more, we use the birefringence of liquid crystal molecules. The liquid crystal application that we are familiar with is liquid crystal display, but this is to change the arrangement of the liquid crystal molecules through the electric current, thus show different light signals. Here, we modify the liquid crystal cell substrate with antibodies. After combining antigens, the micro-environment of the liquid crystal cell platform changes, resulting in a significant difference in color or brightness , the visualization of detection is achieved. </p>
+
                ],
<p>This project will propose a low-cost, portable and visible method for monitoring early renal injury and provide medical advice for patients with hypertension and diabetes.
+
                reply: [
</p>
+
                    {
</div>
+
                        question: "Skip",
 +
                        answer: "dest"
 +
                    },
 +
                    {
 +
                        question: "Listen",
 +
                        answer: "listen1"
 +
                    }
 +
                ]
 +
            },
 +
            "dest": {
 +
                says: ["Please select the destination you want to go to."],
 +
                reply: [
 +
                    {
 +
                        question: "No, thank you.",
 +
                        answer: "end"
 +
                    },
 +
                    {
 +
                        question: "Project Introduction",
 +
                        answer: "projectIntroduction"
 +
                    },
 +
                    {
 +
                        question: "Parts",
 +
                        answer: "parts"
 +
                    },
 +
                    {
 +
                        question: "Model",
 +
                        answer: "model"
 +
                    },
 +
                    {
 +
                        question: "Awards",
 +
                        answer: "awards"
 +
                    },
 +
                    {
 +
                        question: "Human Practices",
 +
                        answer: "humanPractices"
 +
                    },
 +
                    {
 +
                        question: "Teamwork and Cooperation",
 +
                        answer: "teamworkAndCooperation"
 +
                    }
 +
                ]
 +
            },
 +
            "listen1": {
 +
                says: [
 +
                    "Here is iGEM_DLUT_China_B.",
 +
                    "I`ll introduce our project to you.",
 +
                    "Many diseases in the world severely threaten human health, but some of them can be predicted and cured.",
 +
                    "The first step to prevent disease is to figure out what kind of population may face higher risk.",
 +
                    "For example, diabetic and hypertensive patients are more likely to suffer from chronic kidney disease.",
 +
                    "People older than 60 are more likely to develop Alzheimer`s disease."
 +
                ],
 +
                reply: [
 +
                    {
 +
                        question: "And then?",
 +
                        answer: "listen2"
 +
                    }
 +
                ]
 +
            },
 +
            "listen2": {
 +
                says: ["The second step is to monitor regularly to intervene the occurrence and development of diseases timely."],
 +
                reply: [
 +
                    {
 +
                        question: "Yes, it makes sense. But how can it be achieved?",
 +
                        answer: "listen3"
 +
                    }
 +
                ]
 +
            },
 +
            "listen3": {
 +
                says: [
 +
                    "You may not believe that",
 +
                    "we can know our current physical condition through urine.",
 +
                    "Urine is considered to be \"gold mine\" for the identification of disease markers."
 +
                ],
 +
                reply: [
 +
                    {
 +
                        question: "Is that true?",
 +
                        answer: "listen4"
 +
                    }
 +
                ]
 +
            },
 +
            "listen4": {
 +
                says: [
 +
                    "Absolutely. It`s like a mirror that reflects one`s health.",
 +
                    "In the early stages of a disease, we can use the protein markers in the urine to screen the disease."
 +
                ],
 +
                reply: [
 +
                    {
 +
                        question: "But how do you screen it?",
 +
                        answer: "listen5"
 +
                    }
 +
                ]
 +
            },
 +
            "listen5": {
 +
                says: ["We use nano-antibody combining with liquid crystal sensor to show the results for us."],
 +
                reply: [
 +
                    {
 +
                        question: "Liquid crystal? How?",
 +
                        answer: "listen6"
 +
                    }
 +
                ]
 +
            },
 +
            "listen6": {
 +
                says: [
 +
                    "In our daily life, we usually find the LCD screen black. However, it becomes colorful when it works.",
 +
                    "Our products are similar to it in principle.",
 +
                    "The combination of the nano-antibody and the marked protein in urine will result in a slight change in the liquid crystalline substrate.",
 +
                    "It also causes changes in the brightness and color of the liquid crystal film.",
 +
                    "So the liquid crystal brightness can reflect the antigen concentration directly."
 +
                ],
 +
                reply: [
 +
                    {
 +
                        question: "That means we can know whether we are sick and what extent the disease has progressed to.",
 +
                        answer: "listen7"
 +
                    }
 +
                ]
 +
            },
 +
            "listen7": {
 +
                says: [
 +
                    "Yes, but we need to do a more accurate quantitative analysis.",
 +
                    "We take photos, then perform greyscale processing and analyze the average greyscale.",
 +
                    "In contrast to the concentration-gray curve we have obtained, we can obtain the concentration of the antigen accurately."
 +
                ],
 +
                reply: [
 +
                    {
 +
                        question: "You guys did something amazing!",
 +
                        answer: "last"
 +
                    }
 +
                ]
 +
            },
 +
            "last": {
 +
                says: [
 +
                    "Summary has ended, the following is for each plate specific content.",
 +
                    "Please select the destination you want to go to."
 +
                ],
 +
                reply: [
 +
                    {
 +
                        question: "No, thank you.",
 +
                        answer: "end"
 +
                    },
 +
                    {
 +
                        question: "Project Introduction",
 +
                        answer: "projectIntroduction"
 +
                    },
 +
                    {
 +
                        question: "Parts",
 +
                        answer: "parts"
 +
                    },
 +
                    {
 +
                        question: "Model",
 +
                        answer: "model"
 +
                    },
 +
                    {
 +
                        question: "Awards",
 +
                        answer: "awards"
 +
                    },
 +
                    {
 +
                        question: "Human Practices",
 +
                        answer: "humanPractices"
 +
                    },
 +
                    {
 +
                        question: "Teamwork and Cooperation",
 +
                        answer: "teamworkAndCooperation"
 +
                    }
 +
                ]
 +
            },
 +
            "projectIntroduction": {
 +
                says: [
 +
                    "Wow, you selected Project as the destination.",
 +
                    "Are you ready to go?"
 +
                ],
 +
                reply: [
 +
                    {
 +
                        question: "Yes.",
 +
                        answer: "goProjectIntroduction"
 +
                    },
 +
                    {
 +
                        question: "Wait a second.",
 +
                        answer: "dest"
 +
                    }
 +
                ]
 +
            },
 +
            "parts": {
 +
                says: [
 +
                    "Didi, you are about to reach Parts.",
 +
                    "You will learn about the main components we use such as messages."
 +
                ],
 +
                reply: [
 +
                    {
 +
                        question: "OK, let`s go.",
 +
                        answer: "goParts"
 +
                    },
 +
                    {
 +
                        question: "Wait a second.",
 +
                        answer: "dest"
 +
                    }
 +
                ]
 +
            },
 +
            "model": {
 +
                says: [
 +
                    "Have you decided to make Model as your destination?",
 +
                    "Project optimization and results will be exhibited here."
 +
                ],
 +
                reply: [
 +
                    {
 +
                        question: "Go and visit.",
 +
                        answer: "goModel"
 +
                    },
 +
                    {
 +
                        question: "I want another destination.",
 +
                        answer: "dest"
 +
                    }
 +
                ]
 +
            },
 +
            "awards": {
 +
                says: [
 +
                    "You will find the treasures of application design at Awards office."
 +
                ],
 +
                reply: [
 +
                    {
 +
                        question: "Go. ( ̄)  ̄) ↗",
 +
                        answer: "goAwards"
 +
                    },
 +
                    {
 +
                        question: "I`m not interested in treasure hunt.",
 +
                        answer: "dest"
 +
                    }
 +
                ]
 +
            },
 +
            "humanPractices": {
 +
                says: [
 +
                    "We are committed to education and publicity.",
 +
                    "Choose \"Learn more\" and you will arrive at Human Practices.",
 +
                    "Choose \"Back\", the destination will be reset."
 +
                ],
 +
                reply: [
 +
                    {
 +
                        question: "Learn more",
 +
                        answer: "goHumanPractices"
 +
                    },
 +
                    {
 +
                        question: "Back",
 +
                        answer: "dest"
 +
                    }
 +
                ]
 +
            },
 +
            "teamworkAndCooperation": {
 +
                says: [
 +
                    "Choose \"Learn more\", you will arrive at Team Introduction,",
 +
                    "and learn about our team members and our collaborations with other teams.",
 +
                    "Choose \"Back\", the destination will be reset."
 +
                ],
 +
                reply: [
 +
                    {
 +
                        question: "Learn more",
 +
                        answer: "goTeamworkAndCooperation"
 +
                    },
 +
                    {
 +
                        question: "Back",
 +
                        answer: "dest"
 +
                    }
 +
                ]
 +
            },
 +
            end: {
 +
                says: [
 +
                    "Thanks for your time and attention.",
 +
                    "The chat is over, but you can start over to go through other options."
 +
                ],
 +
                reply: [
 +
                    {
 +
                        question: "Start over",
 +
                        answer: "ice"
 +
                    }
 +
                ]
 +
            }
 +
        };
 +
        goProjectIntroduction = function () {
 +
            window.location.href = "https://2018.igem.org/Team:DLUT_China_B/Description";
 +
        };
 +
        goParts = function () {
 +
            window.location.href = "https://2018.igem.org/Team:DLUT_China_B/Parts";
 +
        };
 +
        goModel = function () {
 +
            window.location.href = "https://2018.igem.org/Team:DLUT_China_B/GrayValueConcentrationModel";
 +
        };
 +
        goAwards = function () {
 +
            window.location.href = "https://2018.igem.org/Team:DLUT_China_B/Applied_Design";
 +
        };
 +
        goHumanPractices = function () {
 +
            window.location.href = "https://2018.igem.org/Team:DLUT_China_B/Human_Practices";
 +
        };
 +
        goTeamworkAndCooperation = function () {
 +
            window.location.href = "https://2018.igem.org/Team:DLUT_China_B/TeamMembers";
 +
        };
  
<!--
+
        function isShow($el) {
<div class="column full_size" >
+
            let winH = $(window).height(), /*获取窗口高度*/
 +
                scrollH = $(window).scrollTop(), /*获取窗口滚动高度*/
 +
                top = $el.offsetTop; /*获取元素距离窗口顶部偏移高度*/
 +
            return top < scrollH + winH;
 +
        }
  
<h3>Before you start</h3>
+
        let chatWindow;
<p> Please read the following pages:</p>
+
<ul>
+
<li>  <a href="https://2018.igem.org/Competition">Competition Hub</a> </li>
+
<li> <a href="https://2018.igem.org/Competition/Deliverables/Wiki">Wiki Requirements page</a></li>
+
<li> <a href="https://2018.igem.org/Resources/Template_Documentation">Template documentation</a></li>
+
</ul>
+
</div>
+
  
 +
        function lazyLoad() {
 +
            if (document.getElementById("chat") == null)
 +
                if (isShow(document.getElementById("chatBubbles"))) {
 +
                    let chat = document.createElement("div");
 +
                    chat.setAttribute("id", "chat");
 +
                    document.getElementById("chatBubbles").appendChild(chat);
 +
                    chatWindow = new Bubbles(document.getElementById("chat"), "chatWindow");
 +
                    chatWindow.talk(conversation);
 +
                }
 +
        }
  
<div class="clear extra_space"></div>
+
        $(document).ready(function () {
<div class="line_divider"></div>
+
            $(window).scroll(function () {
<div class="clear extra_space"></div>
+
                topToggle();
 
+
            });
 
+
            $(window).scroll(function () {
 
+
                lazyLoad();
<div class="column full_size" >
+
            });
<h3> Styling your wiki </h3>
+
        })
<p>You may style this page as you like or you can simply leave the style as it is. You can easily keep the styling and edit the content of these default wiki pages with your project information and completely fulfill the requirement to document your project.</p>
+
    </script>
<p>While you may not win Best Wiki with this styling, your team is still eligible for all other awards. This default wiki meets the requirements, it improves navigability and ease of use for visitors, and you should not feel it is necessary to style beyond what has been provided.</p>
+
 
+
 
</div>
 
</div>
 
+
</body>
 
+
 
+
 
+
<div class="clear extra_space"></div>
+
 
+
 
+
 
+
<div class="column third_size" >
+
 
+
<h3> Uploading pictures and files </h3>
+
<p> You must upload any pictures and files to the iGEM 2018 server. Remember to keep all your pictures and files within your team's namespace or at least include your team's name in the file name. </p>
+
 
+
 
+
<p>When you upload, set the "Destination Filename" to <b> T--YourOfficialTeamName--NameOfFile.jpg</b>. (If you don't do this, someone else might upload a different file with the same "Destination Filename", and your file would be erased!)</p>
+
 
+
<div class="button_link">
+
<a href="https://2018.igem.org/Special:Upload">
+
UPLOAD FILES
+
</a>
+
</div>
+
 
+
</div>
+
 
+
<div class="column third_size" >
+
<h3> Wiki template information </h3>
+
<p>We have created these wiki template pages to help you get started and to help you think about how your team will be evaluated. You can find a list of all the pages tied to awards here at the <a href="https://2018.igem.org/Judging/Pages_for_Awards">Pages for awards</a> link. You must edit these pages to be evaluated for medals and awards, but ultimately the design, layout, style and all other elements of your team wiki is up to you!</p>
+
 
+
</div>
+
 
+
 
+
 
+
<div class="column third_size" >
+
<div class="highlight decoration_B_full">
+
<h3> Editing your wiki </h3>
+
<p>On this page you can document your project, introduce your team members, document your progress and share your iGEM experience with the rest of the world! </p>
+
<p>Use WikiTools - Edit in the black menu bar to edit this page</p>
+
 
+
<div class="button_link">
+
<a href="https://2018.igem.org/wiki/index.php?title=Team:DLUT_China_B&action=edit">
+
EDIT PAGE
+
</a>
+
</div>
+
 
+
 
+
</div>
+
</div>
+
 
+
 
+
 
+
 
+
 
+
<div class="clear extra_space"></div>
+
<div class="line_divider"></div>
+
<div class="clear extra_space"></div>
+
 
+
 
+
 
+
<div class="column two_thirds_size" >
+
<h3>Tips</h3>
+
<p>This wiki will be your team’s first interaction with the rest of the world, so here are a few tips to help you get started: </p>
+
<ul>
+
<li>State your accomplishments! Tell people what you have achieved from the start. </li>
+
<li>Be clear about what you are doing and how you plan to do this.</li>
+
<li>You have a global audience! Consider the different backgrounds that your users come from.</li>
+
<li>Make sure information is easy to find; nothing should be more than 3 clicks away.  </li>
+
<li>Avoid using very small fonts and low contrast colors; information should be easy to read.  </li>
+
<li>Start documenting your project as early as possible; don’t leave anything to the last minute before the Wiki Freeze. For a complete list of deadlines visit the <a href="https://2018.igem.org/Calendar">iGEM 2018 calendar</a> </li>
+
<li>Have lots of fun! </li>
+
</ul>
+
</div>
+
 
+
 
+
<div class="column third_size">
+
<div class="highlight decoration_A_full">
+
<h3>Inspiration</h3>
+
<p> You can also view other team wikis for inspiration! Here are some examples:</p>
+
<ul>
+
<li> <a href="https://2014.igem.org/Team:SDU-Denmark/"> 2014 SDU Denmark </a> </li>
+
<li> <a href="https://2014.igem.org/Team:Aalto-Helsinki">2014 Aalto-Helsinki</a> </li>
+
<li> <a href="https://2014.igem.org/Team:LMU-Munich">2014 LMU-Munich</a> </li>
+
<li> <a href="https://2014.igem.org/Team:Michigan"> 2014 Michigan</a></li>
+
<li> <a href="https://2014.igem.org/Team:ITESM-Guadalajara">2014 ITESM-Guadalajara </a></li>
+
<li> <a href="https://2014.igem.org/Team:SCU-China"> 2014 SCU-China </a></li>
+
</ul>
+
</div>
+
</div>
+
-->
+
 
+
 
+
 
+
 
</html>
 
</html>

Latest revision as of 02:42, 18 October 2018

2018 iGEM_DLUT_B

Click bubbles to chat with me