Difference between revisions of "Team:SSTi-SZGD"

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<link rel="stylesheet" type="text/css" href="https://2018.igem.org/Team:SSTi-SZGD/css/Home?action=raw&ctype=text/css">
 
<link rel="stylesheet" type="text/css" href="https://2018.igem.org/Team:SSTi-SZGD/css/Home?action=raw&ctype=text/css">
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<link rel="stylesheet" type="text/css" href="https://2018.igem.org/Team:SSTi-SZGD/css/Footer?action=raw&ctype=text/css">
 
<script src="https://2018.igem.org/Team:SSTi-SZGD/js/Home?action=raw&ctype=text/javascript" type="text/javascript" charset="utf-8"></script>
 
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<script src="https://2018.igem.org/Team:SSTi-SZGD/js/Footer?action=raw&ctype=text/javascript" type="text/javascript" charset="utf-8"></script>
 
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<!--page_content-->
 
<!--page_content-->
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<div class="page_content">
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<div class="page_content container">
 
 
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<!--slogan-->
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<div class="col-xs-12 col-sm-10 name hidden-xs">Team:SSTi-SZGD</div>
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<section class="container-fluid slogan">
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<div class="col-xs-12 col-sm-10 name visible-xs">SSTi-SZGD</div>
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<!--ProjectVideo-->
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<div class="slogan_mask">
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<section class="col-xs-12 col-sm-10 ProjectVideo">
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<video width="100%" controls="controls">
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<div class="Hyaluronic">
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<source src="https://static.igem.org/mediawiki/2018/9/90/T--SSTi-SZGD--ProjectVideo.mp4" type="video/mp4" />
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Hyaluronic acid micro factory : A bacterium produces low molecular weight hyaluronic acid
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<source src="movie.ogg" type="video/ogg" />
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<!--{cn}透明质酸微工厂：一菌直接生产小分子透明质酸-->
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<source src="https://static.igem.org/mediawiki/2018/9/9c/T--SSTi-SZGD--ProjectVideo.webm" type="video/webm" />
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<object data="https://static.igem.org/mediawiki/2018/9/90/T--SSTi-SZGD--ProjectVideo.mp4" width="100%">
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<embed src="movie.swf" width="100%" />
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<div class="used">
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Engineering strain : Bacillus subtilis
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</video>
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<!--{cn}工程菌株：枯草芽孢杆菌-->
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</div>
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<div class="origin">
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Genetic origin : Streptococcus equi and Leech
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<!--{cn}遗传起源：马链球菌和水蛭-->
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</div>
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<div class="href_slogan">
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<a href="#description">
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read more
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<!--{cn}阅读更多-->
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<div class="col-xs-12 col-md-6 content">
 
<div class="col-xs-12 col-md-6 content">
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Now is a younger world, more people pay attention to their appearance, and the development of cosmetics is increasing.
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In our modern world, millions of people do not hesitate to spend a fortune to achieve younger looking and vibrant appearances, thus the cosmetic industry keeps growing.
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<!--{cn}现在是一个年轻的世界，越来越多的人注重自己的外表，并且化妆品的发展日益增加。-->
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<!--{cn}在我们的现代社会，数以百万计的人会不假思索地花一大笔钱，以获得更年轻和更加充满活力的外观，因此化妆品行业不断增长。-->
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The most common substance in cosmetics is hyaluronic acid, which has a good moisturizing ability. And it can remove wrinkles that can make people look younger.
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Hyaluronic acid is one of the mostly used ingredients in cosmetic products, thanks to its exceptional water retention ability that helps rejuvenating skin and reducing wrinkles.  
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<!--{cn}化妆品中最常见的物质是透明质酸，具有良好的保湿能力。 它可以去除皱纹，使人看起来更年轻。-->
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<!--{cn}透明质酸是化妆品中最常用的成分之一，因为它具有超强的保水能力，可以帮助皮肤恢复活力，减少皱纹。-->
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General use streptococus to produce HA but it have risk of infection.So we construct a recombinant Bacillus subtilis strain to produce high molecular weight hyaluronic acid.
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Hyaulornic acid production via microbial fermentation is generally through
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<!--{cn}一般使用兽疫链球菌产生HA，但它有感染的风险。因此我们构建了重组枯草芽孢杆菌菌株以产生高分子量透明质酸。-->
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<!--{cn}通过微生物发酵产生的下透明质酸通常是通过-->
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<i>Streptococus<!--{cn}兽疫链球菌--></i>
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species, which contains endotoxins. We constructed recombinant  
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<!--{cn}，但其中含有内毒素。为了安全的大量生产透明质酸，我们构建了食品级安全菌-->
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<i>Bacillus subtilis<!--{cn}枯草芽孢杆菌--></i>
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, the food-grade safe species, to mass produce hyaluronic acid.
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<!--{cn}。-->
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<div class="col-xs-12 col-md-6 content">
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Only Low molecular weight hyaluronic acid has stable structure after cross-linking and can be made for a cosmetic.So we recombinant our strain again,make it can produce LMW-HA.
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After covalently cross-link, low molecular weight hyaluronic acid (LMW-HA) forms stable hydrogel that is important for film-forming process. By introducing a hydrolase gene, we constructed a
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<!--{cn}只有低分子量的透明质酸在交联后才具有稳定的结构，可以制成化妆品。所以我们再次重组我们的菌株，使其能够生产LMW-HA。-->
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<!--{cn}低分子量透明质酸(LMW-HA)共价交联后形成稳定的水凝胶，对成膜过程具有重要意义。通过引入水解酶基因，构建了一株能够生物合成LMW-HA的-->
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<i>B. Subtilis<!--{cn}枯草芽孢杆菌--></i>
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strain that is able to biosynthesize LMW-HA.
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<!--{cn}菌株。-->
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<div class="col-xs-12 col-sm-8 Cimg">
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<img src="https://static.igem.org/mediawiki/2018/thumb/4/40/T--SSTi-SZGD--home_hamp.png/800px-T--SSTi-SZGD--home_hamp.png"/>
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<div class="col-xs-12 content">
 
<div class="col-xs-12 content">
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Hyaluronic Acid Micro-Needles Patch !!!
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We developed a novel cosmetic product: HA Micro-Needle Patch !!!
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<!--{cn}透明质酸微针贴片!!!-->
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<!--{cn}我们开发了一种新型的化妆品:透明质酸微针贴片!!!-->
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<!--Footer-->
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<footer class="container-fluid page_footer">
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<!--Sponsor-->
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<section class="Sponsor container">
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<div class="col-xs-12">
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<img src="https://static.igem.org/mediawiki/2018/5/58/T--SSTi-SZGD--Sponsor.png"/>
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<!--page_copyright-->
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<section class="container-fluid page_copyright">
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Copyright © 2018 SSTi-SZGD All Rights Reserved.
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</section>
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</footer>
 
 
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Latest revision as of 05:50, 2 November 2018

SSTi-SZGD
In our modern world, millions of people do not hesitate to spend a fortune to achieve younger looking and vibrant appearances, thus the cosmetic industry keeps growing.
Hyaluronic acid is one of the mostly used ingredients in cosmetic products, thanks to its exceptional water retention ability that helps rejuvenating skin and reducing wrinkles.
Hyaulornic acid production via microbial fermentation is generally through Streptococus species, which contains endotoxins. We constructed recombinant Bacillus subtilis , the food-grade safe species, to mass produce hyaluronic acid.
After covalently cross-link, low molecular weight hyaluronic acid (LMW-HA) forms stable hydrogel that is important for film-forming process. By introducing a hydrolase gene, we constructed a B. Subtilis strain that is able to biosynthesize LMW-HA.
We developed a novel cosmetic product: HA Micro-Needle Patch !!!
Copyright © 2018 SSTi-SZGD All Rights Reserved.

Copyright © 2018 SSTi-SZGD All Rights Reserved.