Difference between revisions of "Team:Paris Bettencourt"

 
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  <img src="https://static.igem.org/mediawiki/2018/6/63/T--Paris_Bettencourt--STARCORE_logo.png">
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<h2>Protein scaffolds for star-shaped antimicrobial peptides</h2>
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<p><b>StarCores</b> are these novel, biologically-synhesized, star-shaped Antimicrobial Peptide (AMP). Like antibiotics, AMPs can be used to kill harmful bacteria. Since AMPs attack bacteria differently than conventional antibiotics, <b>the resistance evolution occurs at a much slower rate.</b></br>
  
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<p>We designed StarCores in response to the specific needs of veterinarians, farmers, and policymakers in France. Our goal was to provide a specific solution for killing Gram-negative bacteria on pig farms. Over the summer, we successfully designed, produced, tested, and optimized a novel class of bacteria-killing peptides with <b>high activity and reduced toxicity.</b></br>
  
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<p>The story of our project unfolds sequentially. For the best experience of our wiki, we invite you to read the sections below in order, starting with <b>Integrated Human Practices (Human Practices I)</b>.</p>
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<h1> Star/Cores: Protein scaffolds for star-shaped AMPs </h1>
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<p>The emergence and spread of antibiotic resistance is a major public health concern. There is a clear need for new antimicrobial compounds against infectious diseases. Antimicrobial peptides (AMPs) are a promising novel therapeutic agent. These peptides are widespread in nature and found among all classes of organisms from bacteria to humans. They show broad-spectrum antimicrobial activity and low rates of evolved resistance because they mainly target bacterial membranes. However, the current generation of AMPs has some limitations: potential toxicity to mammalian cells, susceptibility to protease degradation, and high costs and complexity of chemical synthesis. Our project will prototype a new platform for the discovery and production of peptide-based star polymers in which multiple AMPs are fused to an oligomeric protein core. This will allow the bioproduction of AMPs via a tractable model organism. Furthermore, its particular architecture is expected to enhance its antimicrobial efficacy, compared to traditional AMP monomers.</p>
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<h3>Before you start</h3>
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<p> Please read the following pages:</p>
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<li>  <a href="https://2018.igem.org/Competition">Competition Hub</a> </li>
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<li> <a href="https://2018.igem.org/Competition/Deliverables/Wiki">Wiki Requirements page</a></li>
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<li> <a href="https://2018.igem.org/Resources/Template_Documentation">Template documentation</a></li>
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            <a href='https://2018.igem.org/Team:Paris_Bettencourt/Human_Practices'>
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                <div class='large-block-content'>
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                    <img src="https://static.igem.org/mediawiki/2018/5/54/T--Paris_Bettencourt--HP_Firstpage.jpg">
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                </div>
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                <div>Human Practices I </div>
  
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<h3> Styling your wiki </h3>
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<p>You may style this page as you like or you can simply leave the style as it is. You can easily keep the styling and edit the content of these default wiki pages with your project information and completely fulfill the requirement to document your project.</p>
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<p>While you may not win Best Wiki with this styling, your team is still eligible for all other awards. This default wiki meets the requirements, it improves navigability and ease of use for visitors, and you should not feel it is necessary to style beyond what has been provided.</p>  
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            <a href='https://2018.igem.org/Team:Paris_Bettencourt/Design'>
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                <div class='medium-square-block-content'>
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                    <img src="https://static.igem.org/mediawiki/2018/0/0d/T--Paris_Bettencourt--Design_FirstPage.png">
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                </div>
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                <div>Design</div>
  
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            </a>
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              <a href='https://2018.igem.org/Team:Paris_Bettencourt/Production'>
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                    <img src="https://static.igem.org/mediawiki/2018/7/71/T--Paris_Bettencourt--Production_FirstPage.png">
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                </div>
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                <div>Production</div>
  
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              <a href='https://2018.igem.org/Team:Paris_Bettencourt/Testing'>
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                    <img src="https://static.igem.org/mediawiki/2018/5/5e/T--Paris_Bettencourt--Testing_FirstPage.png">
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                <div>Testing</div>
  
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              <a href='https://2018.igem.org/Team:Paris_Bettencourt/Modeling'>
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                <div class='medium-square-block-content'>
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                    <img src="https://static.igem.org/mediawiki/2018/3/3d/T--Paris_Bettencourt--Modeling_FirstPage.png">
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                </div>
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                <div>Modeling</div>
  
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              <a href='https://2018.igem.org/Team:Paris_Bettencourt/Optimization'>
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                    <img src="https://static.igem.org/mediawiki/2018/d/df/T--Paris_Bettencourt--Optimization_FirstPage.png">
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                </div>
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                <div>Optimization</div>
  
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            </a>
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<h3> Uploading pictures and files </h3>
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<p> You must upload any pictures and files to the iGEM 2018 server. Remember to keep all your pictures and files within your team's namespace or at least include your team's name in the file name. </p>
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            <a href='https://2018.igem.org/Team:Paris_Bettencourt/Public_Engagement'>
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                  <img src="https://static.igem.org/mediawiki/2018/7/71/T--Paris_Bettencourt--HPII_FirstPage.png">
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                </div>
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                <div>Human Practices II (Public Engagement)</div>
  
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<p>When you upload, set the "Destination Filename" to <b> T--YourOfficialTeamName--NameOfFile.jpg</b>. (If you don't do this, someone else might upload a different file with the same "Destination Filename", and your file would be erased!)</p>
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<a href="https://2018.igem.org/Special:Upload">
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UPLOAD FILES
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<div class='textbody'>
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        <div class='small-block'>
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            <a href='https://2018.igem.org/Team:Paris_Bettencourt/Members'>
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                <div class='small-block-content'>
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                    <img src="https://static.igem.org/mediawiki/2018/9/97/T--Paris_Bettencourt--Team_FirstPage.png">
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                </div>
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                <div>Team</div>
  
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            </a>
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        </div>
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        <div class='small-block'>
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            <a href='https://2018.igem.org/Team:Paris_Bettencourt/Lab_Notebook'>
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                <div class='small-block-content'>
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                    <img src="https://static.igem.org/mediawiki/2018/a/a6/T--Paris_Bettencourt--Lab_NoteBook.png">
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                <div>Lab Notebook</div>
  
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<h3> Wiki template information </h3>
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<p>We have created these wiki template pages to help you get started and to help you think about how your team will be evaluated. You can find a list of all the pages tied to awards here at the <a href="https://2018.igem.org/Judging/Pages_for_Awards">Pages for awards</a> link. You must edit these pages to be evaluated for medals and awards, but ultimately the design, layout, style and all other elements of your team wiki is up to you!</p>
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            <a href='https://2018.igem.org/Team:Paris_Bettencourt/BioBricks'>
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                    <img src="https://static.igem.org/mediawiki/2018/3/38/T--Paris_Bettencourt--Bio_Bricks.png">
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                <div>BioBricks</div>
  
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            <a href='https://2018.igem.org/Team:Paris_Bettencourt/Medal_Criteria'>
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                    <img src="https://static.igem.org/mediawiki/2018/c/ca/T--Paris_Bettencourt--Medal_FirstPage.png">
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                </div>
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                <div>Medal Criteria</div>
  
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<h3> Editing your wiki </h3>
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<p>On this page you can document your project, introduce your team members, document your progress and share your iGEM experience with the rest of the world! </p>  
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<p>Use WikiTools - Edit in the black menu bar to edit this page</p>
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  <h3>Giant Jamboree 2018 Results!</h3>
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<a href="https://2018.igem.org/wiki/index.php?title=Team:Paris_Bettencourt&action=edit">  
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  <b>Gold Medal </b><br>
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EDIT PAGE
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  Nominations for <b>Best New Composite Part </b> and <b>Best Software</b><br><b><a href="https://synbiobeta.com/cell-free-expression-platforms-enable-new-possibilities-at-igem-and-beyond/">Synbiobeta wrote an article on us! </b>
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{{Paris_Bettencourt/Templatesbottom}}

Latest revision as of 00:50, 8 December 2018

Protein scaffolds for star-shaped antimicrobial peptides

StarCores are these novel, biologically-synhesized, star-shaped Antimicrobial Peptide (AMP). Like antibiotics, AMPs can be used to kill harmful bacteria. Since AMPs attack bacteria differently than conventional antibiotics, the resistance evolution occurs at a much slower rate.

We designed StarCores in response to the specific needs of veterinarians, farmers, and policymakers in France. Our goal was to provide a specific solution for killing Gram-negative bacteria on pig farms. Over the summer, we successfully designed, produced, tested, and optimized a novel class of bacteria-killing peptides with high activity and reduced toxicity.

The story of our project unfolds sequentially. For the best experience of our wiki, we invite you to read the sections below in order, starting with Integrated Human Practices (Human Practices I).

Human Practices I
Design
Production
Testing
Modeling
Optimization
Human Practices II (Public Engagement)
Team
Lab Notebook
BioBricks
Medal Criteria



Giant Jamboree 2018 Results!


Gold Medal
Nominations for Best New Composite Part and Best Software
Synbiobeta wrote an article on us!

Centre for Research and Interdisciplinarity (CRI)
Faculty of Medicine Cochin Port-Royal, South wing, 2nd floor
Paris Descartes University
24, rue du Faubourg Saint Jacques
75014 Paris, France
paris-bettencourt-2018@cri-paris.org