Difference between revisions of "Team:NTHU Formosa"
Tommyrpg1010 (Talk | contribs) |
|||
| Line 4: | Line 4: | ||
<style> | <style> | ||
| − | img { | + | img { |
| − | + | display: block; | |
| − | + | margin-left: auto; | |
| − | + | margin-right: auto; | |
| − | } | + | } |
</style> | </style> | ||
| − | <div class="column full_size" > | + | <div class="column full_size"> |
| − | <h1>Welcome to NTHU_Formosa! </h1> | + | <h1>Welcome to NTHU_Formosa! </h1> |
| − | <p>Your team has been approved and you are ready to start the iGEM season! </p> | + | <p>Your team has been approved and you are ready to start the iGEM season! </p> |
| − | <!-- <img src="http://placehold.it/1080x320/c4baba/e4dede"> --> | + | <!-- <img src="http://placehold.it/1080x320/c4baba/e4dede"> --> |
| − | <br><img src="https://static.igem.org/mediawiki/2018/8/82/T--NTHU_Formosa--Logo.jpg"align="middle"><br> | + | <br><img src="https://static.igem.org/mediawiki/2018/8/82/T--NTHU_Formosa--Logo.jpg" align="middle"> |
| + | <br> | ||
</div> | </div> | ||
<div class="column full_size"> | <div class="column full_size"> | ||
| − | + | <h4> Autonomous cell reporter system for non-invasive real-time blood diagnosis </h4> | |
| − | <h4> Autonomous cell reporter system for non-invasive real-time blood diagnosis </h4> | + | <br> |
| − | <br><br> | + | <br> |
| − | People around the world are growing awareness to their health condition. To monitor the health condition, a wide range of biomarkers-- special substances in the bloodstream representing the physiological and pathological states-- has been used in clinical diagnoses1. Blood test is one of the most common way for detecting biomarkers but it suffers from several inevitable drawbacks such as invasiveness, time-consuming procedure, demand for medical staff service, non real-time tracking and so on. These disadvantages may discourage people from the periodic medical checkup. Indeed, according to a survey (of 1862 samples) pulled by our team, nearly half of the participants took blood test less than once a five-year frequency (Fig. 1), which is impractical for early detection and early treatment of diseases. | + | <p> People around the world are growing awareness to their health condition. To monitor the health condition, a wide range of biomarkers-- special substances in the bloodstream representing the physiological and pathological states-- has been used in clinical |
| − | In terms of non-invasive real-time health monitoring, great varieties of wearable devices and smartwatches, working as personal daily fitness trackers, have been developed. The global market of wearable medical devices is estimated to reach $35 billion USD soon. However, most of the current devices are only capable of measuring heart rate, steps taken, calories, quality of sleep and a few other personal metrics. These limited diagnosis information provided by current devices cannot precisely represent the physiological states relating to many diseases. To address this long-standing worldwide issue, we aim to develop a new tool, a non-invasive or minimally-invasive real-time tracking system for the level of specific biomarkers in bloodstream. | + | diagnoses1. Blood test is one of the most common way for detecting biomarkers but it suffers from several inevitable drawbacks such as invasiveness, time-consuming procedure, demand for medical staff service, non real-time tracking and so on. These |
| − | </p> | + | disadvantages may discourage people from the periodic medical checkup. Indeed, according to a survey (of 1862 samples) pulled by our team, nearly half of the participants took blood test less than once a five-year frequency (Fig. 1), which is impractical |
| + | for early detection and early treatment of diseases. In terms of non-invasive real-time health monitoring, great varieties of wearable devices and smartwatches, working as personal daily fitness trackers, have been developed. The global market of wearable | ||
| + | medical devices is estimated to reach $35 billion USD soon. However, most of the current devices are only capable of measuring heart rate, steps taken, calories, quality of sleep and a few other personal metrics. These limited diagnosis information | ||
| + | provided by current devices cannot precisely represent the physiological states relating to many diseases. To address this long-standing worldwide issue, we aim to develop a new tool, a non-invasive or minimally-invasive real-time tracking system for | ||
| + | the level of specific biomarkers in bloodstream. | ||
| + | </p> | ||
</div> | </div> | ||
| − | <br><img src="https://static.igem.org/mediawiki/2018/2/28/T--NTHU_Formosa--circle_2.png" height="400" width="610" align="middle"><br> | + | <br><img src="https://static.igem.org/mediawiki/2018/2/28/T--NTHU_Formosa--circle_2.png" height="400" width="610" align="middle"> |
| + | <br> | ||
<div class="column full_size"> | <div class="column full_size"> | ||
| − | <p> | + | <p> |
| − | To achieve the goal, our team proposed Biowatcher, comprising of a bioluminescence-detecting watch (Biowatch) and most importantly engineered reporter cells that enable detection and autonomous report of the level of almost all kinds of biomarkers in bloodstream. The sensing parts of the reporter cells are powered by nanobodies, the single-domain antibody that can be engineered to detect different biomarkers2. Binding of biomarkers on nanobodies triggers our synthetic gene circuits and in turn induces autonomous bioluminescent system3 as a readout for wearable devices to detect. Our real-time bioluminescence-detecting watch, Biowatch, will track the level of risk factors by measuring the bioluminescence intensity and record the data as numbers and graphs. It will send alert to users once the level of the risk factors is too high. Meanwhile, there will be suggestions of nearby hospitals according to the users’ location. The system will also upload and attribute the data to public health analysis under the users’ consent. (Fig. 2) | + | To achieve the goal, our team proposed Biowatcher, comprising of a bioluminescence-detecting watch (Biowatch) and most importantly engineered reporter cells that enable detection and autonomous report of the level of almost all kinds of biomarkers in |
| − | </p> | + | bloodstream. The sensing parts of the reporter cells are powered by nanobodies, the single-domain antibody that can be engineered to detect different biomarkers2. Binding of biomarkers on nanobodies triggers our synthetic gene circuits and in turn induces |
| + | autonomous bioluminescent system3 as a readout for wearable devices to detect. Our real-time bioluminescence-detecting watch, Biowatch, will track the level of risk factors by measuring the bioluminescence intensity and record the data as numbers and | ||
| + | graphs. It will send alert to users once the level of the risk factors is too high. Meanwhile, there will be suggestions of nearby hospitals according to the users’ location. The system will also upload and attribute the data to public health analysis | ||
| + | under the users’ consent. (Fig. 2) | ||
| + | </p> | ||
</div> | </div> | ||
| − | <br><img src="https://static.igem.org/mediawiki/2018/9/90/T--NTHU_Formosa--project_model.png" height="600" width="400" align="middle"><br> | + | <br><img src="https://static.igem.org/mediawiki/2018/9/90/T--NTHU_Formosa--project_model.png" height="600" width="400" align="middle"> |
| + | <br> | ||
| Line 62: | Line 74: | ||
| − | <div class="column full_size" > | + | <div class="column full_size" > |
<h3> Styling your wiki </h3> | <h3> Styling your wiki </h3> | ||
<p>You may style this page as you like or you can simply leave the style as it is. You can easily keep the styling and edit the content of these default wiki pages with your project information and completely fulfill the requirement to document your project.</p> | <p>You may style this page as you like or you can simply leave the style as it is. You can easily keep the styling and edit the content of these default wiki pages with your project information and completely fulfill the requirement to document your project.</p> | ||
| − | <p>While you may not win Best Wiki with this styling, your team is still eligible for all other awards. This default wiki meets the requirements, it improves navigability and ease of use for visitors, and you should not feel it is necessary to style beyond what has been provided.</p> | + | <p>While you may not win Best Wiki with this styling, your team is still eligible for all other awards. This default wiki meets the requirements, it improves navigability and ease of use for visitors, and you should not feel it is necessary to style beyond what has been provided.</p> |
</div> | </div> | ||
| Line 76: | Line 88: | ||
| − | <div class="column third_size" > | + | <div class="column third_size" > |
<h3> Uploading pictures and files </h3> | <h3> Uploading pictures and files </h3> | ||
| Line 92: | Line 104: | ||
</div> | </div> | ||
| − | <div class="column third_size" > | + | <div class="column third_size" > |
<h3> Wiki template information </h3> | <h3> Wiki template information </h3> | ||
<p>We have created these wiki template pages to help you get started and to help you think about how your team will be evaluated. You can find a list of all the pages tied to awards here at the <a href="https://2018.igem.org/Judging/Pages_for_Awards">Pages for awards</a> link. You must edit these pages to be evaluated for medals and awards, but ultimately the design, layout, style and all other elements of your team wiki is up to you!</p> | <p>We have created these wiki template pages to help you get started and to help you think about how your team will be evaluated. You can find a list of all the pages tied to awards here at the <a href="https://2018.igem.org/Judging/Pages_for_Awards">Pages for awards</a> link. You must edit these pages to be evaluated for medals and awards, but ultimately the design, layout, style and all other elements of your team wiki is up to you!</p> | ||
| − | </div> | + | </div> |
<div class="column third_size" > | <div class="column third_size" > | ||
| − | <div class="highlight decoration_B_full"> | + | <div class="highlight decoration_B_full"> |
<h3> Editing your wiki </h3> | <h3> Editing your wiki </h3> | ||
| − | <p>On this page you can document your project, introduce your team members, document your progress and share your iGEM experience with the rest of the world! </p> | + | <p>On this page you can document your project, introduce your team members, document your progress and share your iGEM experience with the rest of the world! </p> |
<p>Use WikiTools - Edit in the black menu bar to edit this page</p> | <p>Use WikiTools - Edit in the black menu bar to edit this page</p> | ||
<div class="button_link"> | <div class="button_link"> | ||
| − | <a href="https://2018.igem.org/wiki/index.php?title=Team:NTHU_Formosa&action=edit"> | + | <a href="https://2018.igem.org/wiki/index.php?title=Team:NTHU_Formosa&action=edit"> |
EDIT PAGE | EDIT PAGE | ||
</a> | </a> | ||
| Line 126: | Line 138: | ||
| − | <div class="column two_thirds_size" > | + | <div class="column two_thirds_size" > |
<h3>Tips</h3> | <h3>Tips</h3> | ||
<p>This wiki will be your team’s first interaction with the rest of the world, so here are a few tips to help you get started: </p> | <p>This wiki will be your team’s first interaction with the rest of the world, so here are a few tips to help you get started: </p> | ||
| Line 137: | Line 149: | ||
<li>Start documenting your project as early as possible; don’t leave anything to the last minute before the Wiki Freeze. For a complete list of deadlines visit the <a href="https://2018.igem.org/Calendar">iGEM 2018 calendar</a> </li> | <li>Start documenting your project as early as possible; don’t leave anything to the last minute before the Wiki Freeze. For a complete list of deadlines visit the <a href="https://2018.igem.org/Calendar">iGEM 2018 calendar</a> </li> | ||
<li>Have lots of fun! </li> | <li>Have lots of fun! </li> | ||
| − | </ul> | + | </ul> |
</div> | </div> | ||
<div class="column third_size"> | <div class="column third_size"> | ||
| − | <div class="highlight decoration_A_full"> | + | <div class="highlight decoration_A_full"> |
<h3>Inspiration</h3> | <h3>Inspiration</h3> | ||
<p> You can also view other team wikis for inspiration! Here are some examples:</p> | <p> You can also view other team wikis for inspiration! Here are some examples:</p> | ||
Revision as of 07:17, 23 August 2018
Welcome to NTHU_Formosa!
Your team has been approved and you are ready to start the iGEM season!
Autonomous cell reporter system for non-invasive real-time blood diagnosis
People around the world are growing awareness to their health condition. To monitor the health condition, a wide range of biomarkers-- special substances in the bloodstream representing the physiological and pathological states-- has been used in clinical diagnoses1. Blood test is one of the most common way for detecting biomarkers but it suffers from several inevitable drawbacks such as invasiveness, time-consuming procedure, demand for medical staff service, non real-time tracking and so on. These disadvantages may discourage people from the periodic medical checkup. Indeed, according to a survey (of 1862 samples) pulled by our team, nearly half of the participants took blood test less than once a five-year frequency (Fig. 1), which is impractical for early detection and early treatment of diseases. In terms of non-invasive real-time health monitoring, great varieties of wearable devices and smartwatches, working as personal daily fitness trackers, have been developed. The global market of wearable medical devices is estimated to reach $35 billion USD soon. However, most of the current devices are only capable of measuring heart rate, steps taken, calories, quality of sleep and a few other personal metrics. These limited diagnosis information provided by current devices cannot precisely represent the physiological states relating to many diseases. To address this long-standing worldwide issue, we aim to develop a new tool, a non-invasive or minimally-invasive real-time tracking system for the level of specific biomarkers in bloodstream.
To achieve the goal, our team proposed Biowatcher, comprising of a bioluminescence-detecting watch (Biowatch) and most importantly engineered reporter cells that enable detection and autonomous report of the level of almost all kinds of biomarkers in bloodstream. The sensing parts of the reporter cells are powered by nanobodies, the single-domain antibody that can be engineered to detect different biomarkers2. Binding of biomarkers on nanobodies triggers our synthetic gene circuits and in turn induces autonomous bioluminescent system3 as a readout for wearable devices to detect. Our real-time bioluminescence-detecting watch, Biowatch, will track the level of risk factors by measuring the bioluminescence intensity and record the data as numbers and graphs. It will send alert to users once the level of the risk factors is too high. Meanwhile, there will be suggestions of nearby hospitals according to the users’ location. The system will also upload and attribute the data to public health analysis under the users’ consent. (Fig. 2)
