The aspiration to explore how, what we are doing fits into the society required us to first reach out to the public. Connecting to the general public, academia as well as the those who our project is directly aimed to help, the horse owner community, required some different approaches. We have kept the goal throughout the project to make our science as approachable as possible to as many as possible although at times we did dive into specifics. In order to introduce ourselves to different groups with different interests and different pre-knowledge we have been working on several mini-projects such as Symposium “Limits of Life”, lectures for different audiences as well as reaching out via different media.

Symposium – Limits of Life

Human Practices is all about bringing the science to the people and what better way to do this then to create a big event, where everyone (scientists, academics and further citizens) is invited? This was the start of the collaboration between iGEM Uppsala, iGEM Stockholm with further support from iGEM Lund. Our goal was to organise an event that would break down the differences between scientists and non academic citizens by bringing up subjects that everyone can recognize themselves in, as well as introducing synthetic biology to those who wanted to learn more about it. Together we organized a symposium in Uppsala called “Limits of Life” that was divided into two sessions.

Understanding Your Limits

The first session was called “Understanding Your Limits”, where topics covering iGEM, burnout, stress, mindfulness and general tips in balancing your life, no matter what background you might have, were presented. To this session we had invited 3 different speakers, starting with Will Wright (iGEM ambassador), Marie Åsberg (professor emerita at Karolinska Institutet) and Jonas Nielsen (member of Uppsala iGEM 2018). Mr Wright introduced what iGEM is to the mixed audience and explained what challenges every project team encounters no matter what field they may work within, considering the stress factor, and tips of how to avoid them by putting a lot of effort into the structure of the project. Mrs Åsberg then continued with presenting gradually symptoms of burnout and tips on how the individuals can recognise the symptoms and start changing their lifestyle to be more enduring. Mr Nielsen then held a very appreciated workshop within mindfulness to provide a practical tool for the audience to encounter the stressful lifestyle that is so common among us. From this session both the participants and audience learned something new, whether it was a practical tool to handle a stressful lifestyle or learning more about iGEM.

Will answering questions from the audience

Marie explaining the science behind stress

Hacking Life

The second session was called “Hacking Life”, where we organised a panel discussion that introduced the topic of synthetic biology as well as different ethical aspects and future applications. The panel was represented by Hannes Sjöblad (Swedish ambassador for Singularity University (NASA) with a background of biohacking), Per Sandin (associate professor in philosophy, and a senior lecturer in bioethics and environmental ethics at Swedish University of Agricultural Sciences) and Jens Sundström (is a member of the swedish genetics committee and a senior lecturer at the institution for plant biology at Swedish University of Agricultural Sciences). The panel was moderated by Nicolai Dorka (member of Stockholm iGEM 2018) and Niclas Fahlander (member of Uppsala iGEM 2018). From this session both the participants and audience developed new insight into synthetic biology and thus iGEM could decrease further misinterpretation about subjects, such as GMO, that are common among citizens who have none or too little education about it. The interface between humans and different technologies, both silica- and of organic based were also discussed together with its entailing ethical discussions. The scenario was encaptivating enough and involving so many of the people present in the audience that it was hard to push for a break mid-section. Its safe to say both then and in retrospect that people found there time worth spent attending the symposium that day.

My money's in that office, right? If she start giving me some bullshit about it ain't there, and we got to go someplace else and get it, I'm gonna shoot you in the head then and there. Then I'm gonna shoot that bitch in the kneecaps, find out where my goddamn money is. She gonna tell me too. Hey, look at me when I'm talking to you, motherfucker. You listen: we go in there, and that Winston or anybody else is in there, you the first motherfucker to get shot. You understand?

My money's in that office, right? If she start giving me some bullshit about it ain't there, and we got to go someplace else and get it, I'm gonna shoot you in the head then and there. Then I'm gonna shoot that bitch in the kneecaps, find out where my goddamn money is. She gonna tell me too. Hey, look at me when I'm talking to you, motherfucker. You listen: we go in there, and that Winston or anybody else is in there, you the first motherfucker to get shot. You understand?

Look, just because I don't be givin' no man a foot massage don't make it right for Marsellus to throw Antwone into a glass motherfuckin' house, fuckin' up the way the talks. Motherfucker do that shit to me, he better paralyze my ass, 'cause I'll kill the motherfucker, know what I'm sayin'?

Figure 1: Teams of Stockholm, Lund and Uppsala

Figure 2: Discussing GMO´s

Figure 3: Mingle with synthetic biology enthusiasts

Lectures

Taking every chance to spread the word - BEST lecture

BEST (Board of European Students of Technology), an introductory summer course in synthetic biology held in the same lab-corridor. It was a pleasure to present and discuss our project with a group of students already in the mindset of biotechnology. The students found the presentations interesting and inspirational.

The Student Conference in Science and Technology 2018

This conference is an annual event at Uppsala University that besides being a place for science enthusiasts to connect simultaneously, fulfills the purpose of communications training at the faculty of science and technology. Students are given an opportunity to give a presentation on a scientific subject in front of a larger audience and receive feedback on rhetorics. The challenge of this talk was adapting it to the diverse audience - students from different disciplines in different stages of their education. However, the public was bewildered by Wormbuster story. Special interest went to phage-display methodology as by coincidence announcement of this years Nobel prize winners in chemistry came the same morning and was pricing the development of the method.

SynBio-Hour

iGEM Uppsala association arranges SynBio-hour every year inviting all who have interest in synthetic biology and student driven projects. After the general introduction about iGEM , Wormbusters took the stage. The interest for iGEM was sparked in many new minds.

Media

Ridsport - reaching out to horse community

Ridsport is the biggest magazine about equestrianism and horse breeding in Sweden. They found our story and goals interesting and with their help we got to reach the people who we were trying to help. You can find the article [here] .

UNT - engaging the general public

Uppsalas Nya Tidning is the local newspaper in Uppsala. In the middle of summer they visited us for an interview followed up with article. You can read the digital version [here] .

Techna - spreading inspiration among fellow students

Techna - Uppsala Union of Engineering and Science Students own newspaper, featured a series of articles following the teams journey. Covering both science and general project-management stories we popularized iGEM in Swedens historically biggest student city.

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Here is a second paragraph with E.coli written in italics. Any found genes which display promise will have to be validated by qPCR (which is a similar method) in a second run to confirm that they are only expressed due to the strongyle presence. Another approach to tackle our challenge is to screen for interaction between the surface proteins on the strongyle and short peptides. Through affinity screening of a random peptide library displayed on the surface of phages, we can select a peptide with a high affinity to the nematodes surface.