Difference between revisions of "Team:TecMonterrey GDL"
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| + | <h1> Project description </h1> | ||
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| + | Lactobachill: a smart psychobiotic with anxiolytic and antidepressant properties | ||
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| + | The microorganisms that normally reside in the microbiota has been consistently linked to human well-being. Studies show that microbiota not only can impact nutrition and metabolism, but also the mood. Psychobiotics is the field where probiotics and psychotropics (molecules that can alter mood) converge, opening the possibility of therapies where good bacteria can help lighten or reduce the impact of certain psychiatric conditions, such as depression. Depression affects more than 300 million people in the world, shockingly, an increase of more than 18% between 2005 and 2015 was observed according to World Health Organization (2018). There are many barriers towards dealing with depression, from availability of help to non-recognition of the problem. Depression is the leading cause of ill health and disability worldwide. Our Human Practices are centered towards conscientization and against stigmatization of depression; as well as performing a campaign to incentive people to seek aid when they need to. | ||
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| + | On the other hand, there is a strong relationship between systemic inflammation and psychiatric disorders. Our strategy consists of genetically engineering Lactobacillus rhamnosus GG, a natural gut probiotic, into producing and possible secreting soluble IL-6 receptors gp80 (mutated for increased affinity) and gp130 in order to aid reducing trans-signalization of the inflammatory pathway of cytokine interleukin 6. Our system will be triggered by nitrosative stress, which is a known pathway of inflammatory, depressive and stress afflictions. Blocking the trans-signaling of IL-6 system also prevents tryptophan catabolism to serotonin to deviate into other catabolites. This is how Lactobachill, can be used as an alternative treatment for depression as well as other inflammatory disorders. | ||
| + | </p> | ||
<div class="column full_size" > | <div class="column full_size" > | ||
| − | <h1> Welcome to iGEM 2018 | + | <h1> Welcome to iGEM 2018 </h1> |
<p>Your team has been approved and you are ready to start the iGEM season! </p> | <p>Your team has been approved and you are ready to start the iGEM season! </p> | ||
Revision as of 20:26, 29 June 2018
Project description
Lactobachill: a smart psychobiotic with anxiolytic and antidepressant properties The microorganisms that normally reside in the microbiota has been consistently linked to human well-being. Studies show that microbiota not only can impact nutrition and metabolism, but also the mood. Psychobiotics is the field where probiotics and psychotropics (molecules that can alter mood) converge, opening the possibility of therapies where good bacteria can help lighten or reduce the impact of certain psychiatric conditions, such as depression. Depression affects more than 300 million people in the world, shockingly, an increase of more than 18% between 2005 and 2015 was observed according to World Health Organization (2018). There are many barriers towards dealing with depression, from availability of help to non-recognition of the problem. Depression is the leading cause of ill health and disability worldwide. Our Human Practices are centered towards conscientization and against stigmatization of depression; as well as performing a campaign to incentive people to seek aid when they need to. On the other hand, there is a strong relationship between systemic inflammation and psychiatric disorders. Our strategy consists of genetically engineering Lactobacillus rhamnosus GG, a natural gut probiotic, into producing and possible secreting soluble IL-6 receptors gp80 (mutated for increased affinity) and gp130 in order to aid reducing trans-signalization of the inflammatory pathway of cytokine interleukin 6. Our system will be triggered by nitrosative stress, which is a known pathway of inflammatory, depressive and stress afflictions. Blocking the trans-signaling of IL-6 system also prevents tryptophan catabolism to serotonin to deviate into other catabolites. This is how Lactobachill, can be used as an alternative treatment for depression as well as other inflammatory disorders.
Welcome to iGEM 2018
Your team has been approved and you are ready to start the iGEM season!
Before you start
Please read the following pages:
Styling your wiki
You may style this page as you like or you can simply leave the style as it is. You can easily keep the styling and edit the content of these default wiki pages with your project information and completely fulfill the requirement to document your project.
While you may not win Best Wiki with this styling, your team is still eligible for all other awards. This default wiki meets the requirements, it improves navigability and ease of use for visitors, and you should not feel it is necessary to style beyond what has been provided.
Uploading pictures and files
You must upload any pictures and files to the iGEM 2018 server. Remember to keep all your pictures and files within your team's namespace or at least include your team's name in the file name.
When you upload, set the "Destination Filename" to T--YourOfficialTeamName--NameOfFile.jpg. (If you don't do this, someone else might upload a different file with the same "Destination Filename", and your file would be erased!)
Wiki template information
We have created these wiki template pages to help you get started and to help you think about how your team will be evaluated. You can find a list of all the pages tied to awards here at the Pages for awards link. You must edit these pages to be evaluated for medals and awards, but ultimately the design, layout, style and all other elements of your team wiki is up to you!
Editing your wiki
On this page you can document your project, introduce your team members, document your progress and share your iGEM experience with the rest of the world!
Use WikiTools - Edit in the black menu bar to edit this page
Tips
This wiki will be your team’s first interaction with the rest of the world, so here are a few tips to help you get started:
- State your accomplishments! Tell people what you have achieved from the start.
- Be clear about what you are doing and how you plan to do this.
- You have a global audience! Consider the different backgrounds that your users come from.
- Make sure information is easy to find; nothing should be more than 3 clicks away.
- Avoid using very small fonts and low contrast colors; information should be easy to read.
- Start documenting your project as early as possible; don’t leave anything to the last minute before the Wiki Freeze. For a complete list of deadlines visit the iGEM 2018 calendar
- Have lots of fun!
Inspiration
You can also view other team wikis for inspiration! Here are some examples: