Difference between revisions of "Team:New York City"
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| + | <p> Huntington's Disease (HD) is an autosomal dominant disorder that leads to the progressive degeneration of neurons in the brain, which currently has no cure. HD is typically adult-onset and is characterized by a variety of symptoms including amnesia, involuntary movements, poor coordination, and impaired decision-making. Mutations in the huntingtin (HTT) gene causes HD, specifically a trinucleotide repeat of CAG that is abnormally repeated over 40 times. The goal of our project is to test the effectiveness of the plasmid that we generated last year, which targets and blocks endogenous faulty mRNA and releases a corrected RNA strand for proper protein synthesis of the HTT gene. The efficacy of this plasmid will be tested on Huntington cell lines. Since this plasmid has been designed with two different fluorophores to differentiate between the mutated and corrected strands, the effectiveness of this treatment will be tested by evaluating whether the intensity of the corrected fluorophore increases and the mutated fluorophore decreases in the Huntington cell lines.</p> | ||
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<h3>Before you start</h3> | <h3>Before you start</h3> | ||
Revision as of 22:34, 2 August 2018
Welcome to New York City 2018 iGEM Team!
Your team has been approved and you are ready to start the iGEM season!
Project Discription
Huntington's Disease (HD) is an autosomal dominant disorder that leads to the progressive degeneration of neurons in the brain, which currently has no cure. HD is typically adult-onset and is characterized by a variety of symptoms including amnesia, involuntary movements, poor coordination, and impaired decision-making. Mutations in the huntingtin (HTT) gene causes HD, specifically a trinucleotide repeat of CAG that is abnormally repeated over 40 times. The goal of our project is to test the effectiveness of the plasmid that we generated last year, which targets and blocks endogenous faulty mRNA and releases a corrected RNA strand for proper protein synthesis of the HTT gene. The efficacy of this plasmid will be tested on Huntington cell lines. Since this plasmid has been designed with two different fluorophores to differentiate between the mutated and corrected strands, the effectiveness of this treatment will be tested by evaluating whether the intensity of the corrected fluorophore increases and the mutated fluorophore decreases in the Huntington cell lines.
Before you start
Please read the following pages:
Styling your wiki
You may style this page as you like or you can simply leave the style as it is. You can easily keep the styling and edit the content of these default wiki pages with your project information and completely fulfill the requirement to document your project.
While you may not win Best Wiki with this styling, your team is still eligible for all other awards. This default wiki meets the requirements, it improves navigability and ease of use for visitors, and you should not feel it is necessary to style beyond what has been provided.
Uploading pictures and files
You must upload any pictures and files to the iGEM 2018 server. Remember to keep all your pictures and files within your team's namespace or at least include your team's name in the file name.
When you upload, set the "Destination Filename" to T--YourOfficialTeamName--NameOfFile.jpg. (If you don't do this, someone else might upload a different file with the same "Destination Filename", and your file would be erased!)
Wiki template information
We have created these wiki template pages to help you get started and to help you think about how your team will be evaluated. You can find a list of all the pages tied to awards here at the Pages for awards link. You must edit these pages to be evaluated for medals and awards, but ultimately the design, layout, style and all other elements of your team wiki is up to you!
Editing your wiki
On this page you can document your project, introduce your team members, document your progress and share your iGEM experience with the rest of the world!
Use WikiTools - Edit in the black menu bar to edit this page
Tips
This wiki will be your team’s first interaction with the rest of the world, so here are a few tips to help you get started:
- State your accomplishments! Tell people what you have achieved from the start.
- Be clear about what you are doing and how you plan to do this.
- You have a global audience! Consider the different backgrounds that your users come from.
- Make sure information is easy to find; nothing should be more than 3 clicks away.
- Avoid using very small fonts and low contrast colors; information should be easy to read.
- Start documenting your project as early as possible; don’t leave anything to the last minute before the Wiki Freeze. For a complete list of deadlines visit the iGEM 2018 calendar
- Have lots of fun!
Inspiration
You can also view other team wikis for inspiration! Here are some examples: