In an island state such as Taiwan or Japan, the aquaculture is an important industry. However, the Vibrio-related infection of aquatic animal has been a critical threat for a long time.The Vibrio-related infection leads to inestimable financial damage in Taiwan and Japan, thus, exerting huge impact on the global fishery market.

Traditionally, in order to solve the problem of Vibrio infection, the fisherman add antibiotics into the fishpond directly. But in this way, the abuse of antibiotics will lead to irreversible harm to the Mother Nature.

Our goal this year is to design a system which based on the model of succession. Our engineered E. coli will detect the chemicals secreted by Vibrio which is called AHL, then it triggers our engineered bacteria LUX system to produce an antimicrobial peptide called colicin which is able to kill Vibrio.

When the concentration of Vibrio decreases, the LUX system shuts down and triggers the expression of the suicide gene Gp2. Moreover, the regulation system is STAR/ anti – STAR system. Thus, it causes the death of our engineered bacteria and finally causes the increase of Vibrio concentration. In this way, our engineered bacteria coexist with the Vibrio and control the population. Therefore, we can control the Vibrio population and avoid fish and shrimp infection.

We attempt to make an platfrom for igemers, expect us!