| Medal | Requirement | Criteria | Fulfilment |
|---|
| Bronze | Registration | Complete registration and attend the Giant Jamboree | We successfully registered for iGEM and are looking forward to attending the Boston jamboree! |
| Competition Deliverables | Poster, Judging Form, Wiki and Presentation | We have created a poster and presentation to exhibit at the Giant Jamboree, and our judging form can be found here. |
| Attributions | Describe work completed by the team and others | A page describing project attributions can be found here |
| Interlab | Complete Interlab measurement study | We successfully took part in the Interlab measurement study and a page documenting our work can be found here |
| Silver | Validated Part | Add a successfully characterised new part to the BioBrick registry | To enable expression of pTet-controlled constructs in bacterial strains which do not endogenously express TetR, we added the bidirectional pTet promoter, BBa_K2757002, to the registry. More information on the design and characterisation of this part can be found here. |
| Human Practices | Consider the wider implications of the project | Throughout the project, we took steps to better understand the application, safety, and implementation of our design. In addition to our discussions with medical professionals and IBD patients we hosted a number of outreach events and investigated ethical issues associated with GMO probiotics. Read more about our work here. |
| Collaboration | Describe work completed by the team and others | Over the Summer, we worked with a range of iGEM teams from around the world, both inside and outside the lab. A summary of our collaborations can be found here. |
| Gold | Modelling | Construct a meaningful model of the system | As shown here, we created a model of the system in both the time and frequency domain. Our model was integral in highlighting the need for a dual feedback loop to to optimise the response. |
| Integrated Human Practices | Document how the project was guided by Human Practices | A variety of public surveys, patient interviews, and meetings with researchers helped both to guide further research and to shape our design. A notable contribution was the development of an inducible kill switch system to enhance the safety of our probiotic. More information can be found here. |
| Part Improvement | Create and characterise a BioBrick part with a functional improvement on an existing BioBrick part. | We decided to redesign the Art-175/DsbA composite, BBa_K1659002, submitted by the 2015 Oxford iGEM team by linking it with a pTet promoter to create BBa_K2757001, a functional probiotic kill switch. Read more about it here. |
