Team:NAU-CHINA
Description
Recently, immunotherapies for cancer have gradually come into the public eye. Chimeric Antigen Receptor T-Cell Immunotherapy (CAR-T), a most famous therapy in the field of cancer treatment, has been successfully applied to some cases. Despite all of its advantages, however, a serious consequence cannot be overlooked——cytokine release syndrome. In many countries, it has been reported that some patients lost their lives when getting CAR-T treatment, which arouse a lot of controversy and panic. Based on these realities, this year, we are committed to creating a system to relieve or remove cytokine storm which can be potentially caused by CAR-T. Profiting from the working mechanisms of synNotch and recombinase, we can actually control the synthesis and secretion of anti-inflammatory cytokine in order to fight the abnormal accumulation of inflammatory cytokine.
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Inspiration
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