Team:Paris Bettencourt/Results

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@iGEM_Paris

Key Results

Key results from the Testing

• The StarCores we have obtained show antimicrobial activity.
• 8 out of the 10 constructs showed antimicrobial activity towards E. coli while 9 out of the 10 constructs displayed antimicrobial potential towards B. subtilis.
• The top performing StarCore was the Ferritin-Alyteserin fusion, with an activity almost 10 times higher than that of the control. Some StarCores exhibited species-specific killing, being particularly active against E. coli.
• StarCores of varying geometry displayed similar MIC values.
• There was no clear correlation between the geometry of the StarCores and their antimicrobial activity, indicating a non-specific mechanism of action.

Centre for Research and Interdisciplinarity (CRI)
Faculty of Medicine Cochin Port-Royal, South wing, 2nd floor
Paris Descartes University
24, rue du Faubourg Saint Jacques
75014 Paris, France
paris-bettencourt-2018@cri-paris.org