Team:Hong Kong HKU

Welcome to HKU iGEM 2018!

Project description

In vivo DNA nanostructure synthesis

DNA nanostructures have been evolving fast in the past few decades and have found various new applications in biomedicine. The biocompatibility, binding-specificity and programmability of DNA nanostructures make them ideal drug carriers and intracellular imaging labels. Currently, most functional DNA nanostructures are assembled in vitro, using chemically synthesized custom oligos. More efficient mass production of functional DNA nanostructures is crucial, not only to accelerate research progress in this promising field, but also to expand the application of such versatile molecules in biomedicine. In this project, we design new therapeutic DNA nanostructures, explore the potential of mass producing them in bacteria and endeavor to establish an in vivo library of functional DNA nanostructures.

Functional DNA nanostructures

Employing the structural advantages of DNA nanostructures, we design devices for therapeutic and other biomedical applications. The functional performances of these original nanostructures are characterized in vitro and in vivo. We incorporate a variety of DNA strands dynamics into our designs, so as to test the synthetic ability of bacteria.

Bacterial nanostructure production

Our bacteria are genetically engineered to produce the DNA nanostructures we design. This way our therapeutic devices can be biologically produced in large scale. The components of all our devices are genetically stored and can be produced upon induction. Establishment of such a bacterial library allows convenient storage, production and extraction of DNA nanostructures, promoting DNA nanostructure research and application.

Before you start

Please read the following pages:

Styling your wiki

You may style this page as you like or you can simply leave the style as it is. You can easily keep the styling and edit the content of these default wiki pages with your project information and completely fulfill the requirement to document your project.

While you may not win Best Wiki with this styling, your team is still eligible for all other awards. This default wiki meets the requirements, it improves navigability and ease of use for visitors, and you should not feel it is necessary to style beyond what has been provided.

Uploading pictures and files

You must upload any pictures and files to the iGEM 2018 server. Remember to keep all your pictures and files within your team's namespace or at least include your team's name in the file name.

When you upload, set the "Destination Filename" to T--YourOfficialTeamName--NameOfFile.jpg. (If you don't do this, someone else might upload a different file with the same "Destination Filename", and your file would be erased!)

Wiki template information

We have created these wiki template pages to help you get started and to help you think about how your team will be evaluated. You can find a list of all the pages tied to awards here at the Pages for awards link. You must edit these pages to be evaluated for medals and awards, but ultimately the design, layout, style and all other elements of your team wiki is up to you!

Editing your wiki

On this page you can document your project, introduce your team members, document your progress and share your iGEM experience with the rest of the world!

Use WikiTools - Edit in the black menu bar to edit this page

Tips

This wiki will be your team’s first interaction with the rest of the world, so here are a few tips to help you get started:

  • State your accomplishments! Tell people what you have achieved from the start.
  • Be clear about what you are doing and how you plan to do this.
  • You have a global audience! Consider the different backgrounds that your users come from.
  • Make sure information is easy to find; nothing should be more than 3 clicks away.
  • Avoid using very small fonts and low contrast colors; information should be easy to read.
  • Start documenting your project as early as possible; don’t leave anything to the last minute before the Wiki Freeze. For a complete list of deadlines visit the iGEM 2018 calendar
  • Have lots of fun!

Inspiration

You can also view other team wikis for inspiration! Here are some examples: