Biological part characterization is the core requirement for engineering complex, yet predictable biosystems. The immense complexity of nature makes this a challenging task. Currently, there is a considerable lack of well-defined, standardized parts and an insufficient grasp of their sequence-function relationship. Notably, state of the art screening methods have insufficient throughput to effectively navigate the extensive biomolecule sequence space. To address this issue we have developed a novel approach to part characterization based on microfluidics and modified nucleotides: Catalytic Activity Sequencing (CAT-Seq). CAT-Seq enables the simultaneous activity measurements of billions of biomolecule variants in parallel. Unique biomolecules are each synthesized in separate water droplets and their activity is recorded and stored into their individual DNA sequences. This information can then be readily retrieved by next-generation sequencing. CAT-Seq can rapidly assess sequence-function relationships, characterize regulatory parts, their interactions, and provide much-needed data for predictively designing novel biological systems.
Have any questions or propositions? Send them to Laurynas.Karpus@gmc.vu.lt! Best of luck!
Styling your wiki
You may style this page as you like or you can simply leave the style as it is. You can easily keep the styling and edit the content of these default wiki pages with your project information and completely fulfill the requirement to document your project.
While you may not win Best Wiki with this styling, your team is still eligible for all other awards. This default wiki meets the requirements, it improves navigability and ease of use for visitors, and you should not feel it is necessary to style beyond what has been provided.
Uploading pictures and files
You must upload any pictures and files to the iGEM 2018 server. Remember to keep all your pictures and files within your team's namespace or at least include your team's name in the file name.
When you upload, set the "Destination Filename" to T--YourOfficialTeamName--NameOfFile.jpg. (If you don't do this, someone else might upload a different file with the same "Destination Filename", and your file would be erased!)
Wiki template information
We have created these wiki template pages to help you get started and to help you think about how your team will be evaluated. You can find a list of all the pages tied to awards here at the Pages for awards link. You must edit these pages to be evaluated for medals and awards, but ultimately the design, layout, style and all other elements of your team wiki is up to you!
Editing your wiki
On this page you can document your project, introduce your team members, document your progress and share your iGEM experience with the rest of the world!
Use WikiTools - Edit in the black menu bar to edit this page
This wiki will be your team’s first interaction with the rest of the world, so here are a few tips to help you get started:
- State your accomplishments! Tell people what you have achieved from the start.
- Be clear about what you are doing and how you plan to do this.
- You have a global audience! Consider the different backgrounds that your users come from.
- Make sure information is easy to find; nothing should be more than 3 clicks away.
- Avoid using very small fonts and low contrast colors; information should be easy to read.
- Start documenting your project as early as possible; don’t leave anything to the last minute before the Wiki Freeze. For a complete list of deadlines visit the iGEM 2018 calendar
- Have lots of fun!