Team:NUDT CHINA/Demonstrate

Designed Protein Degradation Method Based on

Trim21 And Nanobody              -- Demonstrate

Our Work

Our Work

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More details

Question 1: What does the structure of domains look like?

There are several variants of derived from different organisms. In our project, we . The structure of this protein has been determined with and without The a lobe. The two lobes are positively charged towards the protein core to accommodate the negatively charged RNA. Each of these two lobes contains an RNase domain. At the main is responsible for target cleavage. In contrast to other two RNase domains of the NUC lobe are located at the outside of the protein, which is likely the reason collateral cleavage upon activation by binding to a matching target. These two domains have been labeled as red spots in Figure 2 and can be found at the interface between the green and pink domain.

Collapsible Group Item #2

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