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<ul class="site-navigation nav navbar-nav pull-right nav-margin object-hidden"> | <ul class="site-navigation nav navbar-nav pull-right nav-margin object-hidden"> | ||
<li> | <li> | ||
− | <a href="https://2018.igem.org/Team:NTU-Singapore" style="padding-top: 17px;">Home</a> | + | <a href="https://2018.igem.org/Team:NTU-Singapore" style="padding-top: 17px; color:white">Home</a> |
</li> | </li> | ||
<li> | <li> | ||
<div class="dropdown"> | <div class="dropdown"> | ||
− | <a href="#" class="dropdown-toggle" data-toggle="dropdown" aria-expanded="false">Team<span class="caret"></span></a> | + | <a href="#" class="dropdown-toggle" data-toggle="dropdown" aria-expanded="false" style="color:white;">Team<span class="caret"></span></a> |
<ul class="dropdown-menu" role="menu"> | <ul class="dropdown-menu" role="menu"> | ||
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<a href="https://2018.igem.org/Team:NTU-Singapore/Collaborations">Collaborations</a> | <a href="https://2018.igem.org/Team:NTU-Singapore/Collaborations">Collaborations</a> | ||
+ | </li> | ||
+ | <li> | ||
+ | <a href="https://2018.igem.org/Team:NTU-Singapore/Attributions">Attributions</a> | ||
</li> | </li> | ||
</ul> | </ul> | ||
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<div class="dropdown"> | <div class="dropdown"> | ||
− | <a href="#" class="dropdown-toggle" data-toggle="dropdown" aria-expanded="false">Project<span class="caret"></span></a> | + | <a href="#" class="dropdown-toggle" data-toggle="dropdown" aria-expanded="false" style="color:white;">Project<span class="caret"></span></a> |
<ul class="dropdown-menu" role="menu"> | <ul class="dropdown-menu" role="menu"> | ||
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</li> | </li> | ||
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− | <a href="https://2018.igem.org/Team:NTU-Singapore/Demonstrate"> | + | <a href="https://2018.igem.org/Team:NTU-Singapore/Demonstrate">Demonstrate</a> |
− | + | ||
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</li> | </li> | ||
</ul> | </ul> | ||
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</li> | </li> | ||
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− | <a href="https://2018.igem.org/Team:NTU-Singapore/InterLab" style="padding-top: 17px;">InterLab</a> | + | <a href="https://2018.igem.org/Team:NTU-Singapore/InterLab" style="padding-top: 17px; color:white;">InterLab</a> |
</li> | </li> | ||
<li> | <li> | ||
<div class="dropdown"> | <div class="dropdown"> | ||
− | <a href="#" class="dropdown-toggle" data-toggle="dropdown" aria-expanded="false">Parts<span class="caret"></span></a> | + | <a href="#" class="dropdown-toggle" data-toggle="dropdown" aria-expanded="false" style="color:white;">Parts<span class="caret"></span></a> |
<ul class="dropdown-menu" role="menu"> | <ul class="dropdown-menu" role="menu"> | ||
− | + | <li> | |
− | + | <a href="https://2018.igem.org/Team:NTU-Singapore/Basic_Part">New Basic Parts</a> | |
− | + | ||
− | + | ||
− | <a href="https://2018.igem.org/Team:NTU-Singapore/Basic_Part">Basic Parts</a> | + | |
</li> | </li> | ||
<li> | <li> | ||
− | <a href="https://2018.igem.org/Team:NTU-Singapore/ | + | <a href="https://2018.igem.org/Team:NTU-Singapore/Improve">Improved Part</a> |
</li> | </li> | ||
</ul> | </ul> | ||
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<div class="dropdown"> | <div class="dropdown"> | ||
− | <a href="#" class="dropdown-toggle" data-toggle="dropdown" aria-expanded="false">Human Practices<span class="caret"></span></a> | + | <a href="#" class="dropdown-toggle" data-toggle="dropdown" aria-expanded="false" style="color:white;">Human Practices<span class="caret"></span></a> |
<ul class="dropdown-menu" role="menu"> | <ul class="dropdown-menu" role="menu"> | ||
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<li> | <li> | ||
<div class="dropdown"> | <div class="dropdown"> | ||
− | <a href="#" class="dropdown-toggle" data-toggle="dropdown" aria-expanded="false">Awards<span class="caret"></span></a> | + | <a href="#" class="dropdown-toggle" data-toggle="dropdown" aria-expanded="false" style="color:white;">Awards<span class="caret"></span></a> |
<ul class="dropdown-menu" role="menu"> | <ul class="dropdown-menu" role="menu"> | ||
<li> | <li> | ||
− | <a href=" | + | <a href="https://2018.igem.org/Team:NTU-Singapore/Medals">Medal Criteria</a> |
</li> | </li> | ||
<li> | <li> | ||
− | <a href=" | + | <a href="https://2018.igem.org/Team:NTU-Singapore/Best_HP">Best Human Practice</a> |
+ | </li> | ||
+ | <li> | ||
+ | <a href="https://2018.igem.org/Team:NTU-Singapore/Measurement">Best Measurement</a> | ||
</li> | </li> | ||
</ul> | </ul> | ||
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</li> | </li> | ||
<li> | <li> | ||
− | <a href="https://igem.org/2018_Judging_Form?id=2818" target="_blank" style="padding-top: 17px;">Judging Form</a> | + | <a href="https://igem.org/2018_Judging_Form?id=2818" target="_blank" style="padding-top: 17px; color:white;">Judging Form</a> |
</li> | </li> | ||
</ul> | </ul> | ||
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</h1> | </h1> | ||
<h3 class="text-center mg-lg hero-bloc-text-sub tc-white "> | <h3 class="text-center mg-lg hero-bloc-text-sub tc-white "> | ||
− | From Genome to Transcriptome, From | + | From Genome to Transcriptome, From Modification to Detection. |
</h3> | </h3> | ||
<div class="text-center"> | <div class="text-center"> | ||
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<div class="col-sm-12"> | <div class="col-sm-12"> | ||
<div class="text-center"> | <div class="text-center"> | ||
− | <a onclick="scrollToTarget('#text-1')"><span class="fa fa-angle-double-down icon-md"></span></a> | + | <a onclick="scrollToTarget('#text-1')"><span class="fa fa-angle-double-down icon-md" style="color:rgba(211,211,211,1);"></span></a> |
</div> | </div> | ||
</div> | </div> | ||
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<div class="col-sm-12"> | <div class="col-sm-12"> | ||
<div class="text-center"> | <div class="text-center"> | ||
− | <a onclick="scrollToTarget('#bloc-3')"><span class="fa fa-angle-double-down icon-md"></span></a> | + | <a onclick="scrollToTarget('#bloc-3')"><span class="fa fa-angle-double-down icon-md" style="color:black;"></span></a> |
</div> | </div> | ||
</div> | </div> | ||
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<div class="col-sm-6"> | <div class="col-sm-6"> | ||
<h2 class="tc-black mg-lg"> | <h2 class="tc-black mg-lg"> | ||
− | Human- | + | Human-Centered Research |
</h2> | </h2> | ||
<p class="mg-lg text-left"> | <p class="mg-lg text-left"> | ||
Our research involves not only the students and scientists, but also the Singapore public. While doing our project, we looked into the public opinions towards gene editing. Our human practice tells how our project evolved around the local community that we live in. | Our research involves not only the students and scientists, but also the Singapore public. While doing our project, we looked into the public opinions towards gene editing. Our human practice tells how our project evolved around the local community that we live in. | ||
− | </p><a href="https://2018.igem.org/Team:NTU-Singapore/ | + | </p><a href="https://2018.igem.org/Team:NTU-Singapore/Human_Practices" class="btn btn-wire btn-rd">Integrated Human Practice</a> |
</div> | </div> | ||
</div> | </div> | ||
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<div class="col-sm-12"> | <div class="col-sm-12"> | ||
<div class="text-center"> | <div class="text-center"> | ||
− | <a onclick="scrollToTarget('#bloc-4')"><span class="fa fa-angle-double-down icon-md"></span></a> | + | <a onclick="scrollToTarget('#bloc-4')"><span class="fa fa-angle-double-down icon-md" style="color:black;"></span></a> |
</div> | </div> | ||
</div> | </div> | ||
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<!-- bloc-4 --> | <!-- bloc-4 --> | ||
− | <div class="bloc bgc-white l-bloc bloc-fill-screen full-width-bloc" id="bloc-4"> | + | <div class="bloc bgc-white l-bloc bloc-fill-screen full-width-bloc bg-T--NTU-Singapore--AI" id="bloc-4"> |
<div class="container"> | <div class="container"> | ||
<div class="row row-margin"> | <div class="row row-margin"> | ||
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</h2> | </h2> | ||
<h3 class="text-left mg-md"> | <h3 class="text-left mg-md"> | ||
− | CRISPR/ | + | CRISPR/Cas13 RNA Base Editor |
</h3> | </h3> | ||
<p class="mg-lg text-left"> | <p class="mg-lg text-left"> | ||
− | As we have learnt through our interviews with medical doctors and interaction with the public, it is evident that RNA editing is | + | As we have learnt through our interviews with medical doctors and interaction with the public, it is evident that RNA editing is a hidden gem of gene therapy that awaits to be explored. Hence, we evolved our project and ventured into RNA editing. |
</p><a href="https://2018.igem.org/Team:NTU-Singapore/RNA" class="btn btn-wire btn-rd pull-left">Proejct REPAIR</a> | </p><a href="https://2018.igem.org/Team:NTU-Singapore/RNA" class="btn btn-wire btn-rd pull-left">Proejct REPAIR</a> | ||
</div> | </div> | ||
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<div class="col-sm-12"> | <div class="col-sm-12"> | ||
<div class="text-center"> | <div class="text-center"> | ||
− | <a onclick="scrollToTarget('#bloc-5')"><span class="fa fa-angle-double-down icon-md"></span></a> | + | <a onclick="scrollToTarget('#bloc-5')"><span class="fa fa-angle-double-down icon-md" style="color:black;"></span></a> |
</div> | </div> | ||
</div> | </div> | ||
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Aim Even Higher. | Aim Even Higher. | ||
</h2> | </h2> | ||
− | <h3 class=" mg-md"> | + | <h3 class=" mg-md" style="padding-left:0.3em;"> |
Modification-Sensitive Nanopore Sequencing | Modification-Sensitive Nanopore Sequencing | ||
</h3> | </h3> | ||
− | <p class="mg-lg text-left"> | + | <p class="mg-lg text-left" style="padding-left:0.5em;"> |
− | To address the | + | To address the public concerns around RNA editing technology, we designed an unbiased, accurate RNA sequencing tool. Expanding the nanopore sequencing platform, we hope to enhance the safety of RNA editing and reduce its cost. |
</p><a href="https://2018.igem.org/Team:NTU-Singapore/Nanopore" class="btn btn-wire btn-rd pull-left">Project Nanopore</a> | </p><a href="https://2018.igem.org/Team:NTU-Singapore/Nanopore" class="btn btn-wire btn-rd pull-left">Project Nanopore</a> | ||
</div> | </div> |
Latest revision as of 18:48, 17 October 2018
![](https://static.igem.org/mediawiki/2018/3/3e/T--NTU-Singapore--Logo_Eye.png)
![](https://static.igem.org/mediawiki/2018/2/2b/T--NTU-Singapore--Logo.png)
A CRISPR/Cas Base-Editing Toolkit
From Genome to Transcriptome, From Modification to Detection.
A Continuation and Beyond.
CRISPR/Cas9 DNA Base Editor
With the successful truncated dCas9-mediated transcriptional activation last year, we moved further this year into DNA base editing using CRISPR/Cas9 system. We also improved our truncated dCas9 further with novel strategies for higher binding efficiency.
Project EditorHuman-Centered Research
Our research involves not only the students and scientists, but also the Singapore public. While doing our project, we looked into the public opinions towards gene editing. Our human practice tells how our project evolved around the local community that we live in.
Integrated Human PracticeAdapt to Change.
CRISPR/Cas13 RNA Base Editor
As we have learnt through our interviews with medical doctors and interaction with the public, it is evident that RNA editing is a hidden gem of gene therapy that awaits to be explored. Hence, we evolved our project and ventured into RNA editing.
Proejct REPAIR![](https://static.igem.org/mediawiki/2018/1/10/T--NTU-Singapore--Nanopore_Graphics.png)
Aim Even Higher.
Modification-Sensitive Nanopore Sequencing
To address the public concerns around RNA editing technology, we designed an unbiased, accurate RNA sequencing tool. Expanding the nanopore sequencing platform, we hope to enhance the safety of RNA editing and reduce its cost.
Project Nanopore