Difference between revisions of "Team:William and Mary/Human Practices"

 
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<h1 style="color: black;text-align:center;">Integrated Human Practices</h1>
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<h1>Human Practices</h1>
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<img src="https://static.igem.org/mediawiki/2018/e/e3/T--William_and_Mary--Edu_img.png" style="width:16%;">
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At iGEM we believe societal considerations should be upfront and integrated throughout the design and execution of synthetic biology projects. “Human Practices” refers to iGEM teams’ efforts to actively consider how the world affects their work and the work affects the world. Through your Human Practices activities, your team should demonstrate how you have thought carefully and creatively about whether your project is responsible and good for the world. We invite you to explore issues relating (but not limited) to the ethics, safety, security, and sustainability of your project, and to show how this exploration feeds back into your project purpose, design and execution.
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<div style = 'padding-left: 14%; padding-bottom: 10px;font-size: 25px' ><b>Motivation</b></div>
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<p>For more information, please see the <a href="https://2018.igem.org/Human_Practices">Human Practices Hub</a>. There you will find:</p>
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This year, our team had the opportunity to share our project with several diverse groups of people: a group of middle school medical explorers, our high school summer interns, and the general public who attended our Building with Biology Public Forum. When connecting with each of these groups we shared the basics behind our project and asked for feedback on our idea as well as general opinions about the work.
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<li> an <a href="https://2018.igem.org/Human_Practices/Introduction">introduction</a> to Human Practices at iGEM </li>
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<li>tips on <a href="https://2018.igem.org/Human_Practices/How_to_Succeed">how to succeed</a> including explanations of judging criteria and advice about how to conduct and document your Human Practices work</li>
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<li>descriptions of <a href="https://2018.igem.org/Human_Practices/Examples">exemplary work</a> to inspire you</li>
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<li>links to helpful <a href="https://2018.igem.org/Human_Practices/Resources">resources</a></li>
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<li>And more! </li>
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<div style = 'padding-left: 14%; padding-bottom: 10px;font-size: 25px' ><b>Medical Explorers</b></div>
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These students were incredibly excited about the idea of eavesdropping in on cellular conversations. During our discussion some students were interested in the precision of our measurements, equating our “listening in” to the dynamics of signals to a game of telephone where details are lost over time. This gave us the chance to talk about our measurement of florecens and our use of both a flow cytometer and a plate reader. Although a little challenging for the younger age group, several of the students were very excited about the way the machines worked.
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The other topic that dominated our conversation were the potential applications. The students wanted to know if we could put our edited bacteria into their bodies and still use the same measurements.
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Team member Stephanie Do explaining our project to the Medical Explores during their tour of lab
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<div style = 'padding-left: 14%; padding-bottom: 10px;font-size: 25px' ><b>Summer Interns</b></div>
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<p>On this page, your team should document all of your Human Practices work and activities. You should write about the Human Practices topics you considered in your project, document any activities you conducted to explore these topics (such as engaging with experts and stakeholders), describe why you took a particular approach (including referencing any work you built upon), and explain if and how you integrated takeaways from your Human Practices work back into your project purpose, design and/or execution. </p>
 
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<p>If your team has gone above and beyond in work related to safety, then you should document this work on your Safety wiki page and provide a description and link on this page. If your team has developed education and public engagement efforts that go beyond a focus on your particular project, and for which would like to nominate your team for the Best Education and Public Engagement Special Prize, you should document this work on your Education and Education wiki page and provide a description and link here. </p>
 
 
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The high school students working in our lab for the month of July were more deeply involved with our project than any other groups. One of these students in particular, Davis, committed a lot of time to learning about our project, even attending our lab meetings outside of normal wet lab hours. Davis is hoping to study biomedical engineering in college and as a result was very interested in the potential medical applications of our project. His questions pushed us to think about making a system compatible with animals systems.
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Team member Stephanie Do discussing potential for our project with our summer intern, Davis
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<div style = 'padding-left: 14%; padding-bottom: 10px;font-size: 25px' ><b>Building with Biology</b></div>
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One of our earliest adult outreach programs was our <a href = 'https://2018.igem.org/Team:William_and_Mary/Human_Practices/Continuing_the_Conversation
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' style = "color:green;">Building with Biology Public Forum</a>. Many adults stayed after the event to hear more about our work as an iGEM team and we were happy to share our project. The Building with Biology Forum had a strong human genome editing theme so many of the participants were primed to think about medical uses for synthetic biology. They were especially interested in the potential for our project to help measure the signals in cancer cells and the ultimate goal of not just interpreting signals but interacting with them.
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<p>The iGEM judges will review this page to assess whether you have met the Silver and/or Gold medal requirements based on the Integrated Human Practices criteria listed below. If you nominate your team for the <a href="https://2018.igem.org/Judging/Awards">Best Integrated Human Practices Special Prize</a> by filling out the corresponding field in the <a href="https://2018.igem.org/Judging/Judging_Form">judging form</a>, the judges will also review this page to consider your team for that prize.  
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Team captain Ethan Jones discussing applications of synthetic biology with community members
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<div style = 'padding-left: 14%; padding-bottom: 10px;font-size: 25px' ><b>Impact on Our Project</b></div>
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In all of these conversations there was the common thread of human uses. Our project is designed to interface with natural systems and after hearing the immense interest in implementing this work in humans in particular we began looking for a system which would be compatible with in vivo applications. Eventually we settled on exchanging our chemical sensitive system to a temperature sensitive systems. Temperature is a property that is easy to control dynamically, and has been shown to be important in the regulation of natural systems such as those involved in bacterial pathogenicity [1] and human immune cell function. Further, the system we chose has been demonstrated to be capable of controlling synthetic circuits in vivo [2]. 
 
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<div style = 'padding-left: 14%; padding-bottom: 10px;font-size: 25px' ><b>Education and Public Engagement</b></div>
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See <a href = 'https://2018.igem.org/Team:William_and_Mary/Public_Engagement' style = 'color:green;'</div> here</a> for our education and public engagement efforts.</div>
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<div style = 'padding-left: 14%; padding-bottom: 10px;font-size: 25px' ><b>References</b></div>
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[1] Nandan Kumar Jana, Siddhartha Roy, Bhabatarak Bhattacharyya, Nitai Chandra Mandal; Amino acid changes in the repressor of bacteriophage lambda due to temperature-sensitive mutations in its cI gene and the structure of a highly temperature-sensitive mutant repressor, Protein Engineering, Design and Selection, Volume 12, Issue 3, 1 March 1999, Pages 225–233, https://doi.org/10.1093/protein/12.3.225
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<h3>Silver Medal Criterion #3</h3>
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<p>Convince the judges you have thought carefully and creatively about whether your work is responsible and good for the world. Document how you have investigated these issues and engaged with your relevant communities, why you chose this approach, and what you have learned. Please note that surveys will not fulfill this criteria unless you follow scientifically valid methods. </p>
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<h3>Gold Medal Criterion #1</h3>
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<p>Expand on your silver medal activity by demonstrating how you have integrated the investigated issues into the purpose, design and/or execution of your project. Document how your project has changed based upon your human practices work.
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[2] Piraner, D. I., Abedi, M. H., Moser, B. A., Lee-Gosselin, A., & Shapiro, M. G. (2016). Tunable thermal bioswitches for in vivo control of microbial therapeutics. Nature Chemical Biology, 13(1), 75-80. doi:10.1038/nchembio.2233
 
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<h3>Best Integrated Human Practices Special Prize</h3>
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<p>To compete for the Best Integrated Human Practices prize, please describe your work on this page and also fill out the description on the judging form. </p>
 
  
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<p>How does your project affect society and how does society influence the direction of your project? How might ethical considerations and stakeholder input guide your project purpose and design and the experiments you conduct in the lab? How does this feedback enter into the process of your work all through the iGEM competition? Document a thoughtful and creative approach to exploring these questions and how your project evolved in the process to compete for this award!</p>
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Latest revision as of 01:22, 18 October 2018

Integrated Human Practices

Motivation
This year, our team had the opportunity to share our project with several diverse groups of people: a group of middle school medical explorers, our high school summer interns, and the general public who attended our Building with Biology Public Forum. When connecting with each of these groups we shared the basics behind our project and asked for feedback on our idea as well as general opinions about the work.
Medical Explorers
These students were incredibly excited about the idea of eavesdropping in on cellular conversations. During our discussion some students were interested in the precision of our measurements, equating our “listening in” to the dynamics of signals to a game of telephone where details are lost over time. This gave us the chance to talk about our measurement of florecens and our use of both a flow cytometer and a plate reader. Although a little challenging for the younger age group, several of the students were very excited about the way the machines worked.
The other topic that dominated our conversation were the potential applications. The students wanted to know if we could put our edited bacteria into their bodies and still use the same measurements.
Team member Stephanie Do explaining our project to the Medical Explores during their tour of lab
Summer Interns
The high school students working in our lab for the month of July were more deeply involved with our project than any other groups. One of these students in particular, Davis, committed a lot of time to learning about our project, even attending our lab meetings outside of normal wet lab hours. Davis is hoping to study biomedical engineering in college and as a result was very interested in the potential medical applications of our project. His questions pushed us to think about making a system compatible with animals systems.
Team member Stephanie Do discussing potential for our project with our summer intern, Davis
Building with Biology
One of our earliest adult outreach programs was our Building with Biology Public Forum. Many adults stayed after the event to hear more about our work as an iGEM team and we were happy to share our project. The Building with Biology Forum had a strong human genome editing theme so many of the participants were primed to think about medical uses for synthetic biology. They were especially interested in the potential for our project to help measure the signals in cancer cells and the ultimate goal of not just interpreting signals but interacting with them.
Team captain Ethan Jones discussing applications of synthetic biology with community members
Impact on Our Project
In all of these conversations there was the common thread of human uses. Our project is designed to interface with natural systems and after hearing the immense interest in implementing this work in humans in particular we began looking for a system which would be compatible with in vivo applications. Eventually we settled on exchanging our chemical sensitive system to a temperature sensitive systems. Temperature is a property that is easy to control dynamically, and has been shown to be important in the regulation of natural systems such as those involved in bacterial pathogenicity [1] and human immune cell function. Further, the system we chose has been demonstrated to be capable of controlling synthetic circuits in vivo [2].
Education and Public Engagement
See here for our education and public engagement efforts.
References
[1] Nandan Kumar Jana, Siddhartha Roy, Bhabatarak Bhattacharyya, Nitai Chandra Mandal; Amino acid changes in the repressor of bacteriophage lambda due to temperature-sensitive mutations in its cI gene and the structure of a highly temperature-sensitive mutant repressor, Protein Engineering, Design and Selection, Volume 12, Issue 3, 1 March 1999, Pages 225–233, https://doi.org/10.1093/protein/12.3.225
[2] Piraner, D. I., Abedi, M. H., Moser, B. A., Lee-Gosselin, A., & Shapiro, M. G. (2016). Tunable thermal bioswitches for in vivo control of microbial therapeutics. Nature Chemical Biology, 13(1), 75-80. doi:10.1038/nchembio.2233