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| − | {{NUDT_CHINA}} | + | {{NUDT_CHINA/navbar}} |
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| − | .frontword p{
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| − | width:90%;
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| − | #model1, #model2, #model3{
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| − | .modelling_info1, .modelling_info2, .modelling_info3{
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| − | @media screen and (max-width: 800px){
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| − | .90width img{width: 90%;}
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| − | #model1, #model2, #model3{
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| − | </style>
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| − | <div class="column third_size">
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| − | <a href="#model1"><img class="model1" src="https://static.igem.org/mediawiki/2016/c/c1/T--Manchester--modelling1_pic.png" ></img></a>
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| − | </div>
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| − | <div class="column third_size" >
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| − | <a href="#model2"><img class="model1" src="https://static.igem.org/mediawiki/2016/a/a3/T--Manchester--modelling2_pic.png" alt="What is esemble modelling?"></img></a>
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| − | </div>
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| − | <div class="column third_size" >
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| − | <a href="#model3"><img class="model1" src="https://static.igem.org/mediawiki/2016/4/46/T--Manchester--modelling3_pic.png" alt="What does our modelling achieve?"></img></a>
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| − | </br></br>
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| − | </div>
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| − | <div class="clear"></div>
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| − | <div class="column full_size">
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| − | <h1> Modeling</h1>
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| − | <p>Mathematical models and computer simulations provide a great way to describe the function and operation of BioBrick Parts and Devices. Synthetic Biology is an engineering discipline, and part of engineering is simulation and modeling to determine the behavior of your design before you build it. Designing and simulating can be iterated many times in a computer before moving to the lab. This award is for teams who build a model of their system and use it to inform system design or simulate expected behavior in conjunction with experiments in the wetlab.</p>
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| − | <div class="column full_size">
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| − | <h3> Gold Medal Criterion #3</h3>
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| − | <p>
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| − | Convince the judges that your project's design and/or implementation is based on insight you have gained from modeling. This could be either a new model you develop or the implementation of a model from a previous team. You must thoroughly document your model's contribution to your project on your team's wiki, including assumptions, relevant data, model results, and a clear explanation of your model that anyone can understand.
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| − | <br><br>
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| − | The model should impact your project design in a meaningful way. Modeling may include, but is not limited to, deterministic, exploratory, molecular dynamic, and stochastic models. Teams may also explore the physical modeling of a single component within a system or utilize mathematical modeling for predicting function of a more complex device.
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| − | </p>
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| − | | + | |
| − | <p>
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| − | Please see the <a href="https://2018.igem.org/Judging/Medals"> 2018
| + | |
| − | Medals Page</a> for more information.
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| − | </p>
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| − | </div>
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| − | <div class="column two_thirds_size">
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| − | <h3>Best Model Special Prize</h3>
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| − | | + | |
| − | <p>
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| − | To compete for the <a href="https://2018.igem.org/Judging/Awards">Best Model prize</a>, please describe your work on this page and also fill out the description on the <a href="https://2018.igem.org/Judging/Judging_Form">judging form</a>. Please note you can compete for both the gold medal criterion #3 and the best model prize with this page.
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| − | <br><br>
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| − | You must also delete the message box on the top of this page to be eligible for the Best Model Prize.
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| − | </p>
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| − | | + | |
| − | </div>
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| − | <div class="column third_size">
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| − | <div class="highlight decoration_A_full">
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| − | <h3> Inspiration </h3>
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| − | <p>
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| − | Here are a few examples from previous teams:
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| − | </p>
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| − | <ul>
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| − | <li><a href="https://2016.igem.org/Team:Manchester/Model">2016 Manchester</a></li>
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| − | <li><a href="https://2016.igem.org/Team:TU_Delft/Model">2016 TU Delft</li>
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| − | <li><a href="https://2014.igem.org/Team:ETH_Zurich/modeling/overview">2014 ETH Zurich</a></li>
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| − | <li><a href="https://2014.igem.org/Team:Waterloo/Math_Book">2014 Waterloo</a></li>
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| − | </ul>
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| − | </div>
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| − | </div>
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| − | <div class="col-md-12 column" alt="cover_photo" style="width:100%;height:250px;background-size:cover;background-position:0px -350px; background-image:url(https://static.igem.org/mediawiki/2016/thumb/3/3f/NUDT_CHINA2016_FILES-img-banner-3.0.png/800px-NUDT_CHINA2016_FILES-img-banner-3.0.png);background-repeat:no-repeat;"> | + | <div class="col-md-12 column" alt="cover_photo" style="width:100%;height:250px;background-size:contain;0px -100px; background-image:url(https://static.igem.org/mediawiki/2018/c/c6/T--NUDT_CHINA--banner_model.jpg);background-repeat:no-repeat;"> |
| − | <p style="font-size:36px;margin: 0 0%;padding: 8% 0 0 10%;color: white;">Development of A Novel</p> | + | <p style="font-size:36px;margin: 0 0%;padding: 5% 0 0 10%;color: white;">Designed Protein Degradation Method Based on</p> |
| − | <p style="font-size:36px;margin: 0 0%;padding: 0 0 0 10%;color: white;">Blood-MicroRNA Handy Detection System with CRISPR</p></div> | + | <p style="font-size:36px;margin: 0 0%;padding: 0 0 0 10%;color: white;">Trim21 And Nanobody -- Model</p> |
| | + | </div> |
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| | <div class="container"> | | <div class="container"> |
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| | <div class="row" style="margin-top: 25px"> | | <div class="row" style="margin-top: 25px"> |
| | <div class="col-md-push-1 col-md-10"> | | <div class="col-md-push-1 col-md-10"> |
| − | <h1 style="font-size: 40px;font-weight: 900">Our Work</h1> | + | <h1 style="font-size: 40px;font-weight: 900">Our Work</h1></br> |
| − | <h2 style="font-size: 32px;margin-bottom: 10px;margin-top: 15px;">Our Work</h2>
| + | <p alt="content_add" style="font-size: 18px;"> Our innovative project present a target protein disruption method in order to degrade endogenous target proteins acutely in mammalian cells. </br></br> |
| − | <p alt="content_add" style="font-size: 18px;">hello everyone this is the another example-content part for more imformation. Hello everyone this is the another example-content part for more imformation.Donec id elit non mi porta gravida at eget metus. Fusce dapibus, tellus ac cursus commodo, tortor mauris condimentum nibh, ut fermentum massa justo sit amet risus. Etiam porta sem malesuada magna mollis euismod. Donec sed odio dui. </p> | + | To explain and predict the possibilities within the wetlab limits,we built ODE models and applied our measured data to parameters simulation method based on Bayesian parameter estimation to obtain parameters which fits our reality better. </br></br> |
| − | <p alt="content_add" style="font-size: 18px;">
| + | We use this model to obtain the relation between the expression time of plasmid and protein degradation rate,making it accessible to future teams who want to incorporate our minds into their designs.</br></br> |
| − | Donec id elit non mi porta gravida at eget metus. Fusce dapibus, tellus ac cursus commodo, tortor mauris condimentum nibh, ut fermentum massa justo sit amet risus. Etiam porta sem malesuada magna mollis euismod. Donec sed odio dui.
| + | Through the modeling ,we understand the reaction mechanism more specifically and obtain how different factors influence the degradation process .This model also offers guidelines on choosing detection point and future clinical application.</br></br> </p> |
| − | </p>
| + | |
| | </div> | | </div> |
| | <div class="col-md-12 column" alt = "main_content"> | | <div class="col-md-12 column" alt = "main_content"> |
| | <div class="col-md-8 col-md-push-2 thumbnail" alt="content_pictute"> | | <div class="col-md-8 col-md-push-2 thumbnail" alt="content_pictute"> |
| − | <img alt="300x200" src="https://static.igem.org/mediawiki/2018/9/9b/2018_igem_menu_logo.svg" /> | + | <a href="https://2018.igem.org/Team:NUDT_CHINA/Model/Basic Design"> <img alt="300x200" src="https://static.igem.org/mediawiki/2018/ d/ d0/ T-- NUDT_CHINA-- our_work_da2.jpg" /> </ a> |
| − | <p alt="photo_detail" style="text-align: center;">This is the sign of the famous game!</p>
| + | <p alt="photo_detail" style="text-align: center;">Basic Work</p> |
| − | </div>
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| − |
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| − | <div class="col-md-6 col-md-push-3">
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| − | <!-- <p class="text-center text-info">this is the sign of igem</p> -->
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| − | <p alt="photo_detail" style="text-align: center;"><em>This is the sign of the famous game!</em></p> | + | |
| | </div> | | </div> |
| − | </div>
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| − | <div class="col-md-push-1 col-md-10">
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| − | <p alt="content_add" style="font-size: 18px;">hello everyone this is the another example-content part for more imformation. Hello everyone this is the another example-content part for more imformation.Donec id elit non mi porta gravida at eget metus. Fusce dapibus, tellus ac cursus commodo, tortor mauris condimentum nibh, ut fermentum massa justo sit amet risus. Etiam porta sem malesuada magna mollis euismod. Donec sed odio dui. </p>
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| − | <p alt="content_add" style="font-size: 18px;">
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| − | Donec id elit non mi porta gravida at eget metus. Fusce dapibus, tellus ac cursus commodo, tortor mauris condimentum nibh, ut fermentum massa justo sit amet risus. Etiam porta sem malesuada magna mollis euismod. Donec sed odio dui.
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| − | </p>
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| − | <blockquote style="border-left-color: #18d26e;">
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| − | Maybe you want to write <strong>something interesting thing</strong> here!
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| − | <small>Someone famous in <cite>Source Title</cite></small>
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| − | </blockquote>
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| − | <p alt="content_add" style="font-size: 18px;">hello everyone this is the another example-content part for more imformation. Hello everyone this is the another example-content part for more imformation.Donec id elit non mi porta gravida at eget metus. Fusce dapibus, tellus ac cursus commodo, tortor mauris condimentum nibh, ut fermentum massa justo sit amet risus. Etiam porta sem malesuada magna mollis euismod. Donec sed odio dui. </p>
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| − | <p alt="content_add" style="font-size: 18px;">
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| − | Donec id elit non mi porta gravida at eget metus. Fusce dapibus, tellus ac cursus commodo, tortor mauris condimentum nibh, ut fermentum massa justo sit amet risus. Etiam porta sem malesuada magna mollis euismod. Donec sed odio dui.
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| − | </p>
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| | </div> | | </div> |
| | <div class="col-md-12 column" alt = "main_content"> | | <div class="col-md-12 column" alt = "main_content"> |
| − | <div class="col-md-6 col-md-push-3" alt="content_pictute"> | + | <div class="col-md-6"> |
| − | <div class="row center-block"> | + | <!-- <p class="text-center text-info">this is the sign of igem</p> --> |
| − | <img alt="300x200" src="https://static.igem.org/mediawiki/2018/9/9b/2018_igem_menu_logo.svg" />
| + | <p alt="photo_detail" style="text-align: center;"> <em>GFP</ em></ p> |
| − | <p alt="photo_detail" style="text-align: center;"> This is the sign of the famous game!</ p> | + | |
| − | </div>
| + | |
| | </div> | | </div> |
| − | </div>
| + | |
| − | <div class="col-md- push-1 col-md-10"> | + | < !-- <p class=" text- center text- info">this is the sign of igem</p > --> |
| − | <p alt="content_add" style="font-size: 18px;">hello everyone this is the another example-content part for more imformation. Hello everyone this is the another example-content part for more imformation.Donec id elit non mi porta gravida at eget metus. Fusce dapibus, tellus ac cursus commodo, tortor mauris condimentum nibh, ut fermentum massa justo sit amet risus. Etiam porta sem malesuada magna mollis euismod. Donec sed odio dui. </p>
| + | <p alt=" photo_detail" style=" text- align: center;">< em> ErbB3< /em></ p> |
| − | <p alt="content_add" style="font-size: 18px;">
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| − | Donec id elit non mi porta gravida at eget metus. Fusce dapibus, tellus ac cursus commodo, tortor mauris condimentum nibh, ut fermentum massa justo sit amet risus. Etiam porta sem malesuada magna mollis euismod. Donec sed odio dui.
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| − | </p>
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| − | <table class="table table-striped">
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| − | <caption>The example table for show some data</caption>
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| − | <thead>
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| − | <tr>
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| − | <th>name</th>
| + | |
| − | <th>city</th>
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| − | <th>mail</th>
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| − | </tr>
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| − | </thead>
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| − | <tbody>
| + | |
| − | <tr>
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| − | <td>Tanmay</td>
| + | |
| − | <td>Bangalore</td>
| + | |
| − | <td>560001</td>
| + | |
| − | </tr>
| + | |
| − | <tr>
| + | |
| − | <td>Sachin</td>
| + | |
| − | <td>Mumbai</td>
| + | |
| − | <td>400003</td>
| + | |
| − | </tr>
| + | |
| − | <tr>
| + | |
| − | <td>Uma</td>
| + | |
| − | <td>Pune</td>
| + | |
| − | <td>411027</td>
| + | |
| − | </tr>
| + | |
| − | </tbody>
| + | |
| − | </table>
| + | |
| − | <p alt="content_add" style="font-size: 18px;">
| + | |
| − | Example block-level help text here.There are several variants of derived from different organisms. In our project, we . The structure of this protein has been determined with and without The a lobe. The two lobes are positively charged towards the protein core to accommodate the negatively charged RNA. Each of these two lobes contains an RNase domain. At the main is responsible for target cleavage. In contrast to other two RNase domains of the NUC lobe are located at the outside of the protein, which is likely the reason collateral cleavage upon activation by binding to a matching target. These two domains have been labeled as red spots in Figure 2 and can be found at the interface between the green and pink domain.
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| − | </p>
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| − | <p alt=" content_add" style=" font- size: 18px;"> | + | |
| − | Donec id elit non mi porta gravida at eget metus. Fusce dapibus, tellus ac cursus commodo, tortor mauris condimentum nibh, ut fermentum massa justo sit amet risus. Etiam porta sem malesuada magna mollis euismod. Donec sed odio dui.
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| − | </p>
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| − | | + | |
| − | <div class="col-md-push-1 col-md-4 thumbnail">
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| − | <img alt="300x200" src="https://static.igem.org/mediawiki/2018/9/9b/2018_igem_menu_logo.svg" />
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| | </div> | | </div> |
| − | <div class="col-md-push-3 col-md-4 thumbnail"> | + | <div class="col-md-push-1 col-md-4 thumbnail"> |
| − | <img alt="300x200" src="https://static.igem.org/mediawiki/2018/9/9b/2018_igem_menu_logo.svg" /> | + | <a href="https://2018.igem.org/Team:NUDT_CHINA/Model/Deduction"> <img alt="300x200" src="https://static.igem.org/mediawiki/2018/2/2a/T--NUDT_CHINA--our_work_you2.png"> </a> |
| | + | </div> |
| | + | <div class="col-md-push-3 col-md-4 thumbnail"> |
| | + | <a href="https://2018.igem.org/Team:NUDT_CHINA/Model/Deduction"> <img alt="300x200" src="https://static.igem.org/mediawiki/2018/ d/ da/ T--NUDT_CHINA--our_work_you6. png" > </ a> |
| | </div> | | </div> |
| | </div> | | </div> |
| − | <div class="col-md-push-1 col-md-10">
| + | </div> |
| − | <p alt="content_add" style="font-size: 18px;">
| + | </div> |
| − | Donec id elit non mi porta gravida at eget metus. Fusce dapibus, tellus ac cursus commodo, tortor mauris condimentum nibh, ut fermentum massa justo sit amet risus. Etiam porta sem malesuada magna mollis euismod. Donec sed odio dui.
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| − | </p>
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| − | </div>
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| − | </div>
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| − | </div>
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| − | <header class="section-header">
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| − | <h3>More details</h3>
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| − | </header>
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| − | <div class="col-md-12 column" alt="problem_answer">
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| − | <div class="panel-group" id="panel-1">
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| − | <div class="panel panel-success">
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| − | <div class="panel-heading text-center">
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| − | <a class="panel-title collapsed " data-toggle="collapse" data-parent="#panel-1" href="#panel-element-1" style="color: #079209; font-size: 20px;text-decoration:none;">Question 1: What does the structure of domains look like?</a>
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| − | </div>
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| − | <div id="panel-element-1" class="panel-collapse collapse">
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| − | <div class="panel-body" style="font-size:16px;">
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| − | There are several variants of derived from different organisms. In our project, we . The structure of this protein has been determined with and without The a lobe. The two lobes are positively charged towards the protein core to accommodate the negatively charged RNA. Each of these two lobes contains an RNase domain. At the main is responsible for target cleavage. In contrast to other two RNase domains of the NUC lobe are located at the outside of the protein, which is likely the reason collateral cleavage upon activation by binding to a matching target. These two domains have been labeled as red spots in Figure 2 and can be found at the interface between the green and pink domain.
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| − | </div>
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| − | </div>
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| − | </div>
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| − | <div class="panel panel-success">
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| − | <div class="panel-heading text-center">
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| − | <a class="panel-title collapsed" data-toggle="collapse" data-parent="#panel-1" href="#panel-element-2" style="color: #079209; font-size: 20px;text-decoration:none;">Collapsible Group Item #2</a>
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| − | <div class="panel-body" style="font-size:16px;">
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| − | Anim pariatur cliche...
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| | </html> | | </html> |
| | {{NUDT_CHINA/footer}} | | {{NUDT_CHINA/footer}} |
