Difference between revisions of "Team:Tokyo Tech/Demonstrate"

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  <!-- Site made with Mobirise Website Builder v4.8.1, https://mobirise.com -->
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  <title>Demonstrate</title>
  
  
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<h3>★  ALERT! </h3>
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<section class="engine"><a href="https://mobiri.se/k">develop your own website</a><br></section><section class="header9 cid-r5el55DVH6 mbr-fullscreen mbr-parallax-background" id="header9-g">
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<p>This page is used by the judges to evaluate your team for the <a href="https://2018.igem.org/Judging/Medals">medal criterion</a> or <a href="https://2018.igem.org/Judging/Awards"> award listed below</a>. </p>
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<p> Delete this box in order to be evaluated for this medal criterion and/or award. See more information at <a href="https://2018.igem.org/Judging/Pages_for_Awards"> Instructions for Pages for awards</a>.</p>
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            <h1 class="mbr-section-title align-left mbr-bold pb-3 mbr-fonts-style display-1">Demonstrate</h1>
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            <h3 class="mbr-section-subtitle align-left mbr-light pb-3 mbr-fonts-style display-2">Technical validation that the project can work the real world</h3>
  
  
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<h1>Demonstrate</h1>
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<h3>Gold Medal Criterion #4</h3>
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Teams that can show their system working under real world conditions are usually good at impressing the judges in iGEM. To achieve gold medal criterion #4, convince the judges that your project works. There are many ways in which your project working could be demonstrated, so there is more than one way to meet this requirement. This gold medal criterion was introduced in 2016, so check our what 2016 teams did to achieve their gold medals!
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Please see the <a href="https://2018.igem.org/Judging/Medals">2018 Medals Page</a> for more information.
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                <h1 class="mbr-section-title align-center pb-3 mbr-fonts-style display-2">Biosafety</h1>
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                <span class="mbr-text align-center mbr-fonts-style" style="font-size: 1.2rem">As you can see in Fig. 9, on native virus genome, structural genes and non-structural genes are integrated on the same sequence. Thus, the whole genome are replicated and that make viruses possible to replicate themselves in host cells.</span>
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                <span class="mbr-text align-center mbr-fonts-style" style="font-size: 1.2rem">However, as you can see our construct design in Fig. 10, structural and non-structural regions are splitted so that the pseudo-virus cannot replicate themselves in host cells because RNA polymerase from non-structural V gene cannot replicate structural genes.</span>
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                <span class="mbr-text align-center mbr-fonts-style" style="font-size: 1.2rem">To sum up, our system starts and ends in one place and doesn't harm environment.</span>
  
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                <img src="https://static.igem.org/mediawiki/2018/7/76/T--Tokyo_Tech--infectious_particle_ex.png" width="1400" alt="Mobirise" title="">
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                <span class="mbr-text align-center mbr-fonts-style" style="font-size: 1.2rem">Figure 9: Infection process of native virus and production of infectious pseudo-virus<br></span>
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                <span class="mbr-text align-center mbr-fonts-style" style="font-size: 1.2rem">Figure 10: Infection process of our pseudo-virus for validating biosafety<br></span>
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Latest revision as of 03:51, 18 October 2018

<!DOCTYPE html>

Demonstrate
develop your own website

Demonstrate

Technical validation that the project can work the real world


Biosafety

As you can see in Fig. 9, on native virus genome, structural genes and non-structural genes are integrated on the same sequence. Thus, the whole genome are replicated and that make viruses possible to replicate themselves in host cells. However, as you can see our construct design in Fig. 10, structural and non-structural regions are splitted so that the pseudo-virus cannot replicate themselves in host cells because RNA polymerase from non-structural V gene cannot replicate structural genes. To sum up, our system starts and ends in one place and doesn't harm environment.

Mobirise

Figure 9: Infection process of native virus and production of infectious pseudo-virus

Mobirise

Figure 10: Infection process of our pseudo-virus for validating biosafety

Address

2 Chome-12-1
Ookayama, Meguro, Tokyo

Contacts

Email: igem2018tokyotech@gmail.com

Links

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