Difference between revisions of "Team:Tokyo Tech/Demonstrate"

 
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<section class="engine"><a href="https://mobiri.se/k">develop your own website</a><br></section><section class="header9 cid-r5el55DVH6 mbr-fullscreen mbr-parallax-background" id="header9-g">
  
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            <h1 class="mbr-section-title align-left mbr-bold pb-3 mbr-fonts-style display-1">Demonstrate</h1>
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            <h3 class="mbr-section-subtitle align-left mbr-light pb-3 mbr-fonts-style display-2">Technical validation that the project can work the real world</h3>
  
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                <h1 class="mbr-section-title mbr-bold pb-3 mbr-fonts-style display-1">PROJECT</h1>
 
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                    Click any text to edit or style it. Select text to insert a link. Click blue "Gear" icon in the top right corner to hide/show buttons, text, title and change the block background. Click red "+" in the bottom right corner to add a new block. Use the top left menu to create new pages, sites and add themes.
 
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                    <a class="btn btn-md btn-secondary display-4" href="https://mobirise.com">LEARN MORE</a>
 
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                 <h1 class="mbr-section-title align-center pb-3 mbr-fonts-style display-2">Biosafety</h1>
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                <span class="mbr-text align-center mbr-fonts-style" style="font-size: 1.2rem">As you can see in Fig. 9, on native virus genome, structural genes and non-structural genes are integrated on the same sequence. Thus, the whole genome are replicated and that make viruses possible to replicate themselves in host cells.</span>
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                <span class="mbr-text align-center mbr-fonts-style" style="font-size: 1.2rem">However, as you can see our construct design in Fig. 10, structural and non-structural regions are splitted so that the pseudo-virus cannot replicate themselves in host cells because RNA polymerase from non-structural V gene cannot replicate structural genes.</span>
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                <span class="mbr-text align-center mbr-fonts-style" style="font-size: 1.2rem">To sum up, our system starts and ends in one place and doesn't harm environment.</span>
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                            <p class="mbr-text mb-0 mbr-fonts-style display-7"><br>Dengue virus, which is in the flavivirus family, is a worldwide spread virus and has huge impact on society, however, not many developing countries are recognizing its danger.<br><br></p>
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            <div class="mbr-text col-12 col-md-8 mbr-fonts-style display-7">Dengue virus is unique in terms of its four different serotypes. Multiple infection can easily cause severe dengue, appearing hemorrhage and organ damage. It is important to grasp which serotype the patient is infected, however, there is not enough data about each serotype in a year.<div><br></div><div>To tackle the situation, we took the following two approaches.</div></div>
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                    <li><span style="font-size: 1rem;"><strong>MODELLING</strong>&nbsp;- We succeeded in the development of the serotype prediction system using stochastic process analysis. This system can predict the patient's serotype by simulating the past data. </span><a href="https://mobirise.co/" style="font-size: 1rem; background-color: rgb(255, 255, 255);">Try it now!</a><br></li>
 
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                    <li><strong>FINDING FLAVI</strong>&nbsp;- We also developed the simple and fast testing kit that can detect serotype with fluorescence, so that we can check the patient easily and get enough data to estimate the patients’ serotypes more accurate. <a href="https://mobirise.co/">Try it now!</a></li>
 
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             <div class="mbr-text col-12 col-md-8 mbr-fonts-style display-7">In the future, this system can contribute to other flavivirus detection system.<div><strong><br></strong></div></div>
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                <span class="mbr-text align-center mbr-fonts-style" style="font-size: 1.2rem">Figure 9: Infection process of native virus and production of infectious pseudo-virus<br></span>
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                 <span class="mbr-text align-center mbr-fonts-style" style="font-size: 1.2rem">Figure 10: Infection process of our pseudo-virus for validating biosafety<br></span>
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Latest revision as of 03:51, 18 October 2018

<!DOCTYPE html>

Demonstrate
develop your own website

Demonstrate

Technical validation that the project can work the real world


Biosafety

As you can see in Fig. 9, on native virus genome, structural genes and non-structural genes are integrated on the same sequence. Thus, the whole genome are replicated and that make viruses possible to replicate themselves in host cells. However, as you can see our construct design in Fig. 10, structural and non-structural regions are splitted so that the pseudo-virus cannot replicate themselves in host cells because RNA polymerase from non-structural V gene cannot replicate structural genes. To sum up, our system starts and ends in one place and doesn't harm environment.

Mobirise

Figure 9: Infection process of native virus and production of infectious pseudo-virus

Mobirise

Figure 10: Infection process of our pseudo-virus for validating biosafety

Address

2 Chome-12-1
Ookayama, Meguro, Tokyo

Contacts

Email: igem2018tokyotech@gmail.com

Links

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