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− | <!-- Site made with Mobirise Website Builder v4.8. | + | <!-- Site made with Mobirise Website Builder v4.8.1, https://mobirise.com --> |
<meta charset="UTF-8"> | <meta charset="UTF-8"> | ||
<meta http-equiv="X-UA-Compatible" content="IE=edge"> | <meta http-equiv="X-UA-Compatible" content="IE=edge"> | ||
− | <meta name="generator" content="Mobirise v4.8. | + | <meta name="generator" content="Mobirise v4.8.1, mobirise.com"> |
<meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1"> | <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1"> | ||
<link rel="shortcut icon" href="assets/images/findingflavi-logo-128x52-1.png" type="image/x-icon"> | <link rel="shortcut icon" href="assets/images/findingflavi-logo-128x52-1.png" type="image/x-icon"> | ||
− | <meta name="description" content=" | + | <meta name="description" content=""> |
− | <title> | + | <title>Demonstrate</title> |
+ | <link rel="stylesheet" href="https://2018.igem.org/Team:Tokyo_Tech/mobirise/mobirise/css/mbr-additional-css-ex?action=raw&ctype=text/css"> | ||
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<body> | <body> | ||
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+ | <section class="engine"><a href="https://mobiri.se/k">develop your own website</a><br></section><section class="header9 cid-r5el55DVH6 mbr-fullscreen mbr-parallax-background" id="header9-g"> | ||
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+ | <div class="container"> | ||
+ | <div class="media-container-column mbr-white col-md-8"> | ||
+ | <h1 class="mbr-section-title align-left mbr-bold pb-3 mbr-fonts-style display-1">Demonstrate</h1> | ||
+ | <h3 class="mbr-section-subtitle align-left mbr-light pb-3 mbr-fonts-style display-2">Technical validation that the project can work the real world</h3> | ||
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+ | </div> | ||
+ | </div> | ||
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+ | <div class="mbr-arrow hidden-sm-down" aria-hidden="true"> | ||
+ | <a href="#next"> | ||
+ | <i class="mbri-down mbr-iconfont"></i> | ||
+ | </a> | ||
+ | </div> | ||
+ | <br></section> | ||
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+ | <section class="header5 cid-r6Kzov1weU" id="header5-3a" style="background-color: #000000"> | ||
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<div class="container"> | <div class="container"> | ||
− | <div class=" | + | <div class="row justify-content-center"> |
− | <div class=" | + | <div class="mbr-white col-md-10"> |
− | < | + | <h1 class="mbr-section-title align-center pb-3 mbr-fonts-style display-2">Biosafety</h1> |
− | + | <span class="mbr-text align-center mbr-fonts-style" style="font-size: 1.2rem">As you can see in Fig. 9, on native virus genome, structural genes and non-structural genes are integrated on the same sequence. Thus, the whole genome are replicated and that make viruses possible to replicate themselves in host cells.</span> | |
− | </ | + | <span class="mbr-text align-center mbr-fonts-style" style="font-size: 1.2rem">However, as you can see our construct design in Fig. 10, structural and non-structural regions are splitted so that the pseudo-virus cannot replicate themselves in host cells because RNA polymerase from non-structural V gene cannot replicate structural genes.</span> |
+ | <span class="mbr-text align-center mbr-fonts-style" style="font-size: 1.2rem">To sum up, our system starts and ends in one place and doesn't harm environment.</span> | ||
+ | </div> | ||
+ | </div> | ||
+ | </div> | ||
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+ | <br></section> | ||
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+ | <section class="cid-r6K1p0zJY1" id="image1-2s" style="background-color: #000000"> | ||
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+ | <figure class="mbr-figure container"> | ||
+ | <div class="image-block" style="width: 84%; background-color: #ffffff"> | ||
+ | <img src="https://static.igem.org/mediawiki/2018/7/76/T--Tokyo_Tech--infectious_particle_ex.png" width="1400" alt="Mobirise" title=""> | ||
+ | |||
+ | </div> | ||
+ | </figure> | ||
+ | <br></section> | ||
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+ | <section class="header5 cid-r6JdPuqigd" id="header5-2n"> | ||
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+ | <div class="container"> | ||
+ | <div class="row justify-content-center"> | ||
+ | <div class="mbr-white col-md-10"> | ||
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+ | <span class="mbr-text align-center mbr-fonts-style" style="font-size: 1.2rem">Figure 9: Infection process of native virus and production of infectious pseudo-virus<br></span> | ||
</div> | </div> | ||
</div> | </div> | ||
</div> | </div> | ||
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− | <section class="mbr-section | + | |
+ | <br></section> | ||
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+ | <section class="cid-r6K1p0zJY1" id="image1-2s" style="background-color: #000000"> | ||
+ | |||
+ | |||
+ | |||
+ | <figure class="mbr-figure container"> | ||
+ | <div class="image-block" style="width: 84%; background-color: #ffffff"> | ||
+ | <img src="https://static.igem.org/mediawiki/2018/9/91/T--Tokyo_Tech--presentation9.png" width="1400" alt="Mobirise" title=""> | ||
+ | |||
+ | </div> | ||
+ | </figure> | ||
+ | <br></section> | ||
+ | |||
+ | <section class="header5 cid-r6JdPuqigd" id="header5-2n"> | ||
+ | |||
<div class="container"> | <div class="container"> | ||
− | <div class=" | + | <div class="row justify-content-center"> |
− | <div class="mbr- | + | <div class="mbr-white col-md-10"> |
− | + | ||
+ | <span class="mbr-text align-center mbr-fonts-style" style="font-size: 1.2rem">Figure 10: Infection process of our pseudo-virus for validating biosafety<br></span> | ||
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</div> | </div> | ||
</div> | </div> | ||
</div> | </div> | ||
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+ | <br></section> | ||
</body> | </body> |
Latest revision as of 03:51, 18 October 2018
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Demonstrate
Technical validation that the project can work the real world
Biosafety
As you can see in Fig. 9, on native virus genome, structural genes and non-structural genes are integrated on the same sequence. Thus, the whole genome are replicated and that make viruses possible to replicate themselves in host cells. However, as you can see our construct design in Fig. 10, structural and non-structural regions are splitted so that the pseudo-virus cannot replicate themselves in host cells because RNA polymerase from non-structural V gene cannot replicate structural genes. To sum up, our system starts and ends in one place and doesn't harm environment.
Figure 9: Infection process of native virus and production of infectious pseudo-virus
Figure 10: Infection process of our pseudo-virus for validating biosafety