Difference between revisions of "Team:BGU Israel"
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font-size: 32px!important; | font-size: 32px!important; | ||
font-family: Segoe UI Light!important; | font-family: Segoe UI Light!important; | ||
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color: #303030; | color: #303030; | ||
font-weight: 600; | font-weight: 600; | ||
| − | margin-bottom: | + | margin-bottom: 30px !important; |
} | } | ||
h4 { | h4 { | ||
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.jumbotron { | .jumbotron { | ||
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right:auto !important; | right:auto !important; | ||
border-radius: 0 !important; | border-radius: 0 !important; | ||
| − | + | text-transform: capitalize; | |
| + | font-size:18px; | ||
} | } | ||
| + | @media screen and (min-width: 600px) { | ||
.dropdown:hover .dropdown-menu { | .dropdown:hover .dropdown-menu { | ||
display: block; | display: block; | ||
margin-top: 0; | margin-top: 0; | ||
| + | color:#fff; | ||
} | } | ||
| + | } | ||
#video { | #video { | ||
background-color:#ededed; | background-color:#ededed; | ||
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<li><a href="index.html">Home</a></li> | <li><a href="index.html">Home</a></li> | ||
<li class="dropdown"> | <li class="dropdown"> | ||
| − | <a class="dropdown-toggle" data-toggle="dropdown" href=" | + | <a class="dropdown-toggle" data-toggle="dropdown" href="https://2018.igem.org/Team:BGU_Israel/Description">Project |
| + | </a> | ||
| + | <ul class="dropdown-menu pull-right"> | ||
| + | <li><a href="https://2018.igem.org/Team:BGU_Israel/Description ">Description</a></li> | ||
| + | <li><a href="https://2018.igem.org/Team:BGU_Israel/Design">Design</a></li> | ||
| + | <li><a href="https://2018.igem.org/Team:BGU_Israel/Results">Results</a></li> | ||
| + | <li><a href="https://2018.igem.org/Team:BGU_ISRAEL/Protocols">Protocols</a></li> | ||
| + | <li><a href="https://2018.igem.org/Team:BGU_ISRAEL/Notebook">Notebook</a></li> | ||
| + | |||
| + | </ul> | ||
| + | </li> | ||
| + | <li class="dropdown"> | ||
| + | <a class="dropdown-toggle" data-toggle="dropdown" href="https://2018.igem.org/Team:BGU_Israel/Description">Team | ||
| + | </a> | ||
| + | <ul class="dropdown-menu pull-right"> | ||
| + | <li><a href="https://2018.igem.org/Team:BGU_Israel/Team">Members</a></li> | ||
| + | <li><a href="https://2018.igem.org/Team:BGU_Israel/Collaborations">Collaborations</a></li> | ||
| + | </ul> | ||
| + | </li> | ||
| + | <li class="dropdown"> | ||
| + | <a class="dropdown-toggle" data-toggle="dropdown" href="https://2018.igem.org/Team:BGU_Israel/Description">Parts | ||
| + | </a> | ||
| + | <ul class="dropdown-menu pull-right"> | ||
| + | <li><a href="https://2018.igem.org/Team:BGU_Israel/Parts">Team Parts</a></li> | ||
| + | <li><a href="https://2018.igem.org/Team:BGU_Israel/BasicParts ">Basic Parts</a></li> | ||
| + | <li><a href="https://2018.igem.org/Team:BGU_Israel/PartImprovement">Part Improvement</a></li> | ||
| + | <li><a href="https://2018.igem.org/Team:BGU_Israel/PartCollection">Part Collection</a></li> | ||
| + | </ul> | ||
| + | </li> | ||
| + | |||
| + | <li class="dropdown"> | ||
| + | <a class="dropdown-toggle" data-toggle="dropdown" href="https://2018.igem.org/Team:BGU_Israel/Description">Practices | ||
| + | |||
</a> | </a> | ||
<ul class="dropdown-menu pull-right"> | <ul class="dropdown-menu pull-right"> | ||
| − | <li><a href=" | + | <li><a href="https://2018.igem.org/Team:BGU_ISRAEL/ALSConference">ALS Conference</a></li> |
| − | <li><a href=" | + | <li><a href="https://2018.igem.org/Team:BGU_ISRAEL/ALSFunding">Funding Race</a></li> |
| − | <li><a href=" | + | <li><a href="https://2018.igem.org/Team:BGU_Israel/InterLab">InterLab</a></li> |
| + | <li><a href="https://2018.igem.org/Team:BGU_ISRAEL/EthicsAndSafety">Ethics and Safty</a></li> | ||
</ul> | </ul> | ||
</li> | </li> | ||
| − | <li><a href=" | + | <li><a href="https://2018.igem.org/Team:BGU_ISRAEL/Attributions">Attributions</a></li> |
| − | + | <!--<li><a href="https://2018.igem.org/Team:BGU_ISRAEL/Achievments">Achievments</a></li>--> | |
| − | + | ||
</ul> | </ul> | ||
</div> | </div> | ||
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<div class="col-sm-8 col-sm-offset-2"> | <div class="col-sm-8 col-sm-offset-2"> | ||
<h1>Abstract</h1> | <h1>Abstract</h1> | ||
| − | |||
<p style="margin:0px !important; padding:0!important;" class="mb-4 justified animated fadeInRight">Recent research studies of Amyotrophic Lateral Sclerosis (ALS) suggest that brain cells that have become toxic, directly contribute to the progression of the disease. These cells change their gene expression pattern and possess distinguishing genetic markers. In addition, they drive the death of other cells in the brain among them the motor neurons. <br><br> | <p style="margin:0px !important; padding:0!important;" class="mb-4 justified animated fadeInRight">Recent research studies of Amyotrophic Lateral Sclerosis (ALS) suggest that brain cells that have become toxic, directly contribute to the progression of the disease. These cells change their gene expression pattern and possess distinguishing genetic markers. In addition, they drive the death of other cells in the brain among them the motor neurons. <br><br> | ||
Our objective, as the BGU-IGEM team OriginALS, is to prolong survival of ALS patients via a novel genetic engineering approach. In order to reach this objective, we combine two separate strategies as our therapeutic approach: </p> | Our objective, as the BGU-IGEM team OriginALS, is to prolong survival of ALS patients via a novel genetic engineering approach. In order to reach this objective, we combine two separate strategies as our therapeutic approach: </p> | ||
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<div class="col-sm-8 col-sm-offset-2"> | <div class="col-sm-8 col-sm-offset-2"> | ||
<h1>Long Story Short</h1> | <h1>Long Story Short</h1> | ||
| − | < | + | <!--- |
<video width="100%" controls> | <video width="100%" controls> | ||
<source src="https://static.igem.org/mediawiki/2018/f/fe/IGEM_Human_Practices.mp4" type="video/mp4"> | <source src="https://static.igem.org/mediawiki/2018/f/fe/IGEM_Human_Practices.mp4" type="video/mp4"> | ||
</video> | </video> | ||
| − | + | ---> | |
| + | <iframe width="720" height="405" src="https://www.youtube.com/embed/qyAFAlu17CE?rel=0&showinfo=0" frameborder="0" allow="autoplay; encrypted-media" allowfullscreen></iframe> | ||
</div> | </div> | ||
</div> | </div> | ||
</div> | </div> | ||
| + | <style> | ||
| + | .footer-list { | ||
| + | list-style: none; | ||
| + | color:#a5a5a5; | ||
| + | } | ||
| + | .footer-list-item { | ||
| + | padding:20px 0 20px 0 !important; | ||
| + | border-bottom: 1px solid #a5a5a5; | ||
| + | } | ||
| + | .footer-list .footer-list-item:last-child { | ||
| + | border:0; | ||
| + | } | ||
| + | </style> | ||
| − | + | <footer class="container-fluid"> | |
| − | <footer class="container-fluid | + | <div class="row"> |
| − | + | <div class="col-md-4"> | |
| + | <ul class="footer-list"> | ||
| + | <li class="footer-list-item">Ben-Gurion University of the Negev | ||
| + | Ben Gurion 1, Beer Sheva 8410501, Israel</li> | ||
| + | <li class="footer-list-item">Second item</li> | ||
| + | <li class="footer-list-item">Third item</li> | ||
| + | </ul> | ||
| + | </div> | ||
| + | <div class="col-md-4"> | ||
| + | <ul class="footer-list"> | ||
| + | <li class="footer-list-item">First item</li> | ||
| + | <li class="footer-list-item">Second item</li> | ||
| + | <li class="footer-list-item">Third item</li> | ||
| + | </ul> | ||
| + | </div> | ||
| + | <div class="col-md-4"> | ||
| + | <ul class="footer-list"> | ||
| + | <li class="footer-list-item">First item</li> | ||
| + | <li class="footer-list-item">Second item</li> | ||
| + | <li class="footer-list-item">Third item</li> | ||
| + | <li class="footer-list-item">Third item</li> | ||
| + | </ul> | ||
| + | </div> | ||
| + | |||
| + | </div> | ||
</footer> | </footer> | ||
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}) | }) | ||
</script> | </script> | ||
| − | <script> | + | <script type="text/javascript"> |
/*! | /*! | ||
* parallax.js v1.5.0 (http://pixelcog.github.io/parallax.js/) | * parallax.js v1.5.0 (http://pixelcog.github.io/parallax.js/) | ||
Revision as of 12:34, 29 July 2018
<!DOCTYPE html>
Abstract
Recent research studies of Amyotrophic Lateral Sclerosis (ALS) suggest that brain cells that have become toxic, directly contribute to the progression of the disease. These cells change their gene expression pattern and possess distinguishing genetic markers. In addition, they drive the death of other cells in the brain among them the motor neurons.
Our objective, as the BGU-IGEM team OriginALS, is to prolong survival of ALS patients via a novel genetic engineering approach. In order to reach this objective, we combine two separate strategies as our therapeutic approach:
- We identify and selectively eliminate only the toxic cells. In order to identify and target the toxic-cells only, we use distinguishing markers that are unique only to them.
- We prevent the generation of new toxic cells by genetically targeting specific molecules that generate the toxic cells.
In conclusion, our approach combines an apoptotic destruction of toxic cells with the prevention of the formation of new toxic cells, thus aiming to significantly reduce the occurrence of toxic cells in the central neuronal system (CNS), which is aimed at a significant deceleration of the progression rate of ALS.