Difference between revisions of "Team:BGU Israel"
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padding-bottom: calc(10rem - 56px); | padding-bottom: calc(10rem - 56px); | ||
background-image:url('https://static.igem.org/mediawiki/2018/2/2e/T--BGU_Israel--home_banner.jpg'); | background-image:url('https://static.igem.org/mediawiki/2018/2/2e/T--BGU_Israel--home_banner.jpg'); | ||
| − | + | width:100%; | |
| − | + | overflow: hidden; | |
| − | + | min-height: 700px; | |
| − | + | /* Create the parallax scrolling effect */ | |
| − | + | background-attachment: fixed; | |
| − | + | background-position: center; | |
| − | + | background-repeat: no-repeat; | |
| − | + | background-size: cover; | |
| − | + | ||
| − | background: | + | |
} | } | ||
| + | |||
#abstract p, #abstract ol { | #abstract p, #abstract ol { | ||
text-align: justify; | text-align: justify; | ||
| Line 234: | Line 233: | ||
border-radius: 100px; | border-radius: 100px; | ||
} | } | ||
| − | |||
#myBtn:hover { | #myBtn:hover { | ||
background-color: #555; | background-color: #555; | ||
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} | } | ||
| − | + | ||
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@media screen and (min-width: 600px) { | @media screen and (min-width: 600px) { | ||
.dropdown:hover .dropdown-menu { | .dropdown:hover .dropdown-menu { | ||
| Line 262: | Line 255: | ||
color:#fff; | color:#fff; | ||
} | } | ||
| + | #mainMenu .dropdown-menu { | ||
| + | border:0 !important; | ||
| + | right:auto !important; | ||
| + | border-radius: 0 !important; | ||
| + | text-transform: capitalize; | ||
| + | font-size:18px; | ||
| + | } | ||
} | } | ||
| − | + | #video { | |
background-color:#ededed; | background-color:#ededed; | ||
} | } | ||
| − | + | ||
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</style> | </style> | ||
</head> | </head> | ||
<body id="myPage" data-spy="scroll" data-target=".navbar" data-offset="60"> | <body id="myPage" data-spy="scroll" data-target=".navbar" data-offset="60"> | ||
<div id="top"></div> | <div id="top"></div> | ||
| − | < | + | <button id="myBtn" href="#top" title="To Top"> |
<span class="glyphicon glyphicon-chevron-up"></span> | <span class="glyphicon glyphicon-chevron-up"></span> | ||
| − | </ | + | </button> |
<nav id="mainMenu" class="navbar navbar-default navbar-fixed-top"> | <nav id="mainMenu" class="navbar navbar-default navbar-fixed-top"> | ||
| Line 346: | Line 336: | ||
</div> | </div> | ||
</nav> | </nav> | ||
| − | <header | + | <header class="masthead text-center"> |
<div class="container my-auto"> | <div class="container my-auto"> | ||
| − | |||
</div> | </div> | ||
</header> | </header> | ||
| − | |||
| − | |||
| − | |||
<!-- Container (About Section) --> | <!-- Container (About Section) --> | ||
| − | + | <div id="abstract" class="container-fluid text-center"> | |
| − | + | <div class="row"> | |
| − | + | <div class="col-sm-8 col-sm-offset-2"> | |
| − | + | <h1>Abstract</h1> | |
| − | + | <p style="margin:0px !important; padding:0!important;" class="mb-4 justified animated fadeInRight">Recent research studies of Amyotrophic Lateral Sclerosis (ALS) suggest that brain cells that have become toxic, directly contribute to the progression of the disease. These cells change their gene expression pattern and possess distinguishing genetic markers. In addition, they drive the death of other cells in the brain among them the motor neurons. <br><br> | |
| − | + | Our objective, as the BGU-IGEM team OriginALS, is to prolong survival of ALS patients via a novel genetic engineering approach. In order to reach this objective, we combine two separate strategies as our therapeutic approach: </p> | |
| − | + | <ol class="mb-4 justified animated fadeInRight"> | |
| + | <li> We identify and selectively eliminate only the toxic cells. In order to identify and target the toxic-cells only, we use distinguishing markers that are unique only to them.</li> | ||
| + | <li>We prevent the generation of new toxic cells by genetically targeting specific molecules that generate the toxic cells.</li> | ||
| + | </ol> | ||
| + | <p class="mb-4 justified animated fadeInRight"> | ||
| + | In conclusion, our approach combines an apoptotic destruction of toxic cells with the prevention of the formation of new toxic cells, thus aiming to significantly reduce the occurrence of toxic cells in the central neuronal system (CNS), which is aimed at a significant deceleration of the progression rate of ALS.</p> | ||
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</div> | </div> | ||
| − | + | ||
| − | + | ||
| − | + | ||
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</div> | </div> | ||
</div> | </div> | ||
| − | + | <div id="video" class="container-fluid text-center"> | |
| − | + | ||
| − | + | ||
| − | <div id="video" class="container-fluid text-center | + | |
<div class="row"> | <div class="row"> | ||
<div class="col-sm-8 col-sm-offset-2"> | <div class="col-sm-8 col-sm-offset-2"> | ||
<h1>Long Story Short</h1> | <h1>Long Story Short</h1> | ||
| − | + | <!--- | |
| + | <video width="100%" controls> | ||
| + | <source src="https://static.igem.org/mediawiki/2018/f/fe/IGEM_Human_Practices.mp4" type="video/mp4"> | ||
| + | </video> | ||
| + | ---> | ||
| + | <style>.embed-container { position: relative; padding-bottom: 56.25%; height: 0; overflow: hidden; max-width: 100%; } .embed-container iframe, .embed-container object, .embed-container embed { position: absolute; top: 0; left: 0; width: 100%; height: 100%; }</style><div class='embed-container'><iframe src='https://www.youtube.com/embed/qyAFAlu17CE' frameborder="0" allow="autoplay; encrypted-media" allowfullscreen></iframe></div> | ||
</div> | </div> | ||
| Line 580: | Line 452: | ||
}) | }) | ||
</script> | </script> | ||
| + | <script type="text/javascript"> | ||
| + | /*! | ||
| + | * parallax.js v1.5.0 (http://pixelcog.github.io/parallax.js/) | ||
| + | * @copyright 2016 PixelCog, Inc. | ||
| + | * @license MIT (https://github.com/pixelcog/parallax.js/blob/master/LICENSE) | ||
| + | */ | ||
| + | ;(function ( $, window, document, undefined ) { | ||
| + | |||
| + | // Polyfill for requestAnimationFrame | ||
| + | // via: https://gist.github.com/paulirish/1579671 | ||
| + | |||
| + | (function() { | ||
| + | var lastTime = 0; | ||
| + | var vendors = ['ms', 'moz', 'webkit', 'o']; | ||
| + | for(var x = 0; x < vendors.length && !window.requestAnimationFrame; ++x) { | ||
| + | window.requestAnimationFrame = window[vendors[x]+'RequestAnimationFrame']; | ||
| + | window.cancelAnimationFrame = window[vendors[x]+'CancelAnimationFrame'] || window[vendors[x]+'CancelRequestAnimationFrame']; | ||
| + | } | ||
| + | |||
| + | if (!window.requestAnimationFrame) | ||
| + | window.requestAnimationFrame = function(callback) { | ||
| + | var currTime = new Date().getTime(); | ||
| + | var timeToCall = Math.max(0, 16 - (currTime - lastTime)); | ||
| + | var id = window.setTimeout(function() { callback(currTime + timeToCall); }, | ||
| + | timeToCall); | ||
| + | lastTime = currTime + timeToCall; | ||
| + | return id; | ||
| + | }; | ||
| + | |||
| + | if (!window.cancelAnimationFrame) | ||
| + | window.cancelAnimationFrame = function(id) { | ||
| + | clearTimeout(id); | ||
| + | }; | ||
| + | }()); | ||
| + | |||
| + | |||
| + | // Parallax Constructor | ||
| + | |||
| + | function Parallax(element, options) { | ||
| + | var self = this; | ||
| + | |||
| + | if (typeof options == 'object') { | ||
| + | delete options.refresh; | ||
| + | delete options.render; | ||
| + | $.extend(this, options); | ||
| + | } | ||
| + | |||
| + | this.$element = $(element); | ||
| + | |||
| + | if (!this.imageSrc && this.$element.is('img')) { | ||
| + | this.imageSrc = this.$element.attr('src'); | ||
| + | } | ||
| + | |||
| + | var positions = (this.position + '').toLowerCase().match(/\S+/g) || []; | ||
| + | |||
| + | if (positions.length < 1) { | ||
| + | positions.push('center'); | ||
| + | } | ||
| + | if (positions.length == 1) { | ||
| + | positions.push(positions[0]); | ||
| + | } | ||
| + | |||
| + | if (positions[0] == 'top' || positions[0] == 'bottom' || positions[1] == 'left' || positions[1] == 'right') { | ||
| + | positions = [positions[1], positions[0]]; | ||
| + | } | ||
| + | |||
| + | if (this.positionX !== undefined) positions[0] = this.positionX.toLowerCase(); | ||
| + | if (this.positionY !== undefined) positions[1] = this.positionY.toLowerCase(); | ||
| + | |||
| + | self.positionX = positions[0]; | ||
| + | self.positionY = positions[1]; | ||
| + | |||
| + | if (this.positionX != 'left' && this.positionX != 'right') { | ||
| + | if (isNaN(parseInt(this.positionX))) { | ||
| + | this.positionX = 'center'; | ||
| + | } else { | ||
| + | this.positionX = parseInt(this.positionX); | ||
| + | } | ||
| + | } | ||
| + | |||
| + | if (this.positionY != 'top' && this.positionY != 'bottom') { | ||
| + | if (isNaN(parseInt(this.positionY))) { | ||
| + | this.positionY = 'center'; | ||
| + | } else { | ||
| + | this.positionY = parseInt(this.positionY); | ||
| + | } | ||
| + | } | ||
| + | |||
| + | this.position = | ||
| + | this.positionX + (isNaN(this.positionX)? '' : 'px') + ' ' + | ||
| + | this.positionY + (isNaN(this.positionY)? '' : 'px'); | ||
| + | |||
| + | if (navigator.userAgent.match(/(iPod|iPhone|iPad)/)) { | ||
| + | if (this.imageSrc && this.iosFix && !this.$element.is('img')) { | ||
| + | this.$element.css({ | ||
| + | backgroundImage: 'url(' + this.imageSrc + ')', | ||
| + | backgroundSize: 'cover', | ||
| + | backgroundPosition: this.position | ||
| + | }); | ||
| + | } | ||
| + | return this; | ||
| + | } | ||
| + | |||
| + | if (navigator.userAgent.match(/(Android)/)) { | ||
| + | if (this.imageSrc && this.androidFix && !this.$element.is('img')) { | ||
| + | this.$element.css({ | ||
| + | backgroundImage: 'url(' + this.imageSrc + ')', | ||
| + | backgroundSize: 'cover', | ||
| + | backgroundPosition: this.position | ||
| + | }); | ||
| + | } | ||
| + | return this; | ||
| + | } | ||
| + | |||
| + | this.$mirror = $('<div />').prependTo(this.mirrorContainer); | ||
| + | |||
| + | var slider = this.$element.find('>.parallax-slider'); | ||
| + | var sliderExisted = false; | ||
| + | |||
| + | if (slider.length == 0) | ||
| + | this.$slider = $('<img />').prependTo(this.$mirror); | ||
| + | else { | ||
| + | this.$slider = slider.prependTo(this.$mirror) | ||
| + | sliderExisted = true; | ||
| + | } | ||
| + | |||
| + | this.$mirror.addClass('parallax-mirror').css({ | ||
| + | visibility: 'hidden', | ||
| + | zIndex: this.zIndex, | ||
| + | position: 'fixed', | ||
| + | top: 0, | ||
| + | left: 0, | ||
| + | overflow: 'hidden' | ||
| + | }); | ||
| + | |||
| + | this.$slider.addClass('parallax-slider').one('load', function() { | ||
| + | if (!self.naturalHeight || !self.naturalWidth) { | ||
| + | self.naturalHeight = this.naturalHeight || this.height || 1; | ||
| + | self.naturalWidth = this.naturalWidth || this.width || 1; | ||
| + | } | ||
| + | self.aspectRatio = self.naturalWidth / self.naturalHeight; | ||
| + | |||
| + | Parallax.isSetup || Parallax.setup(); | ||
| + | Parallax.sliders.push(self); | ||
| + | Parallax.isFresh = false; | ||
| + | Parallax.requestRender(); | ||
| + | }); | ||
| + | |||
| + | if (!sliderExisted) | ||
| + | this.$slider[0].src = this.imageSrc; | ||
| + | |||
| + | if (this.naturalHeight && this.naturalWidth || this.$slider[0].complete || slider.length > 0) { | ||
| + | this.$slider.trigger('load'); | ||
| + | } | ||
| + | |||
| + | } | ||
| + | |||
| + | |||
| + | // Parallax Instance Methods | ||
| + | |||
| + | $.extend(Parallax.prototype, { | ||
| + | speed: 0.2, | ||
| + | bleed: 0, | ||
| + | zIndex: -100, | ||
| + | iosFix: true, | ||
| + | androidFix: true, | ||
| + | position: 'center', | ||
| + | overScrollFix: false, | ||
| + | mirrorContainer: 'body', | ||
| + | |||
| + | refresh: function() { | ||
| + | this.boxWidth = this.$element.outerWidth(); | ||
| + | this.boxHeight = this.$element.outerHeight() + this.bleed * 2; | ||
| + | this.boxOffsetTop = this.$element.offset().top - this.bleed; | ||
| + | this.boxOffsetLeft = this.$element.offset().left; | ||
| + | this.boxOffsetBottom = this.boxOffsetTop + this.boxHeight; | ||
| + | |||
| + | var winHeight = Parallax.winHeight; | ||
| + | var docHeight = Parallax.docHeight; | ||
| + | var maxOffset = Math.min(this.boxOffsetTop, docHeight - winHeight); | ||
| + | var minOffset = Math.max(this.boxOffsetTop + this.boxHeight - winHeight, 0); | ||
| + | var imageHeightMin = this.boxHeight + (maxOffset - minOffset) * (1 - this.speed) | 0; | ||
| + | var imageOffsetMin = (this.boxOffsetTop - maxOffset) * (1 - this.speed) | 0; | ||
| + | var margin; | ||
| + | |||
| + | if (imageHeightMin * this.aspectRatio >= this.boxWidth) { | ||
| + | this.imageWidth = imageHeightMin * this.aspectRatio | 0; | ||
| + | this.imageHeight = imageHeightMin; | ||
| + | this.offsetBaseTop = imageOffsetMin; | ||
| + | |||
| + | margin = this.imageWidth - this.boxWidth; | ||
| + | |||
| + | if (this.positionX == 'left') { | ||
| + | this.offsetLeft = 0; | ||
| + | } else if (this.positionX == 'right') { | ||
| + | this.offsetLeft = - margin; | ||
| + | } else if (!isNaN(this.positionX)) { | ||
| + | this.offsetLeft = Math.max(this.positionX, - margin); | ||
| + | } else { | ||
| + | this.offsetLeft = - margin / 2 | 0; | ||
| + | } | ||
| + | } else { | ||
| + | this.imageWidth = this.boxWidth; | ||
| + | this.imageHeight = this.boxWidth / this.aspectRatio | 0; | ||
| + | this.offsetLeft = 0; | ||
| + | |||
| + | margin = this.imageHeight - imageHeightMin; | ||
| + | |||
| + | if (this.positionY == 'top') { | ||
| + | this.offsetBaseTop = imageOffsetMin; | ||
| + | } else if (this.positionY == 'bottom') { | ||
| + | this.offsetBaseTop = imageOffsetMin - margin; | ||
| + | } else if (!isNaN(this.positionY)) { | ||
| + | this.offsetBaseTop = imageOffsetMin + Math.max(this.positionY, - margin); | ||
| + | } else { | ||
| + | this.offsetBaseTop = imageOffsetMin - margin / 2 | 0; | ||
| + | } | ||
| + | } | ||
| + | }, | ||
| + | |||
| + | render: function() { | ||
| + | var scrollTop = Parallax.scrollTop; | ||
| + | var scrollLeft = Parallax.scrollLeft; | ||
| + | var overScroll = this.overScrollFix ? Parallax.overScroll : 0; | ||
| + | var scrollBottom = scrollTop + Parallax.winHeight; | ||
| + | |||
| + | if (this.boxOffsetBottom > scrollTop && this.boxOffsetTop <= scrollBottom) { | ||
| + | this.visibility = 'visible'; | ||
| + | this.mirrorTop = this.boxOffsetTop - scrollTop; | ||
| + | this.mirrorLeft = this.boxOffsetLeft - scrollLeft; | ||
| + | this.offsetTop = this.offsetBaseTop - this.mirrorTop * (1 - this.speed); | ||
| + | } else { | ||
| + | this.visibility = 'hidden'; | ||
| + | } | ||
| + | |||
| + | this.$mirror.css({ | ||
| + | transform: 'translate3d('+this.mirrorLeft+'px, '+(this.mirrorTop - overScroll)+'px, 0px)', | ||
| + | visibility: this.visibility, | ||
| + | height: this.boxHeight, | ||
| + | width: this.boxWidth | ||
| + | }); | ||
| + | |||
| + | this.$slider.css({ | ||
| + | transform: 'translate3d('+this.offsetLeft+'px, '+this.offsetTop+'px, 0px)', | ||
| + | position: 'absolute', | ||
| + | height: this.imageHeight, | ||
| + | width: this.imageWidth, | ||
| + | maxWidth: 'none' | ||
| + | }); | ||
| + | } | ||
| + | }); | ||
| + | |||
| + | |||
| + | // Parallax Static Methods | ||
| + | |||
| + | $.extend(Parallax, { | ||
| + | scrollTop: 0, | ||
| + | scrollLeft: 0, | ||
| + | winHeight: 0, | ||
| + | winWidth: 0, | ||
| + | docHeight: 1 << 30, | ||
| + | docWidth: 1 << 30, | ||
| + | sliders: [], | ||
| + | isReady: false, | ||
| + | isFresh: false, | ||
| + | isBusy: false, | ||
| + | |||
| + | setup: function() { | ||
| + | if (this.isReady) return; | ||
| + | |||
| + | var self = this; | ||
| + | |||
| + | var $doc = $(document), $win = $(window); | ||
| + | |||
| + | var loadDimensions = function() { | ||
| + | Parallax.winHeight = $win.height(); | ||
| + | Parallax.winWidth = $win.width(); | ||
| + | Parallax.docHeight = $doc.height(); | ||
| + | Parallax.docWidth = $doc.width(); | ||
| + | }; | ||
| + | |||
| + | var loadScrollPosition = function() { | ||
| + | var winScrollTop = $win.scrollTop(); | ||
| + | var scrollTopMax = Parallax.docHeight - Parallax.winHeight; | ||
| + | var scrollLeftMax = Parallax.docWidth - Parallax.winWidth; | ||
| + | Parallax.scrollTop = Math.max(0, Math.min(scrollTopMax, winScrollTop)); | ||
| + | Parallax.scrollLeft = Math.max(0, Math.min(scrollLeftMax, $win.scrollLeft())); | ||
| + | Parallax.overScroll = Math.max(winScrollTop - scrollTopMax, Math.min(winScrollTop, 0)); | ||
| + | }; | ||
| + | |||
| + | $win.on('resize.px.parallax load.px.parallax', function() { | ||
| + | loadDimensions(); | ||
| + | self.refresh(); | ||
| + | Parallax.isFresh = false; | ||
| + | Parallax.requestRender(); | ||
| + | }) | ||
| + | .on('scroll.px.parallax load.px.parallax', function() { | ||
| + | loadScrollPosition(); | ||
| + | Parallax.requestRender(); | ||
| + | }); | ||
| + | |||
| + | loadDimensions(); | ||
| + | loadScrollPosition(); | ||
| + | |||
| + | this.isReady = true; | ||
| + | |||
| + | var lastPosition = -1; | ||
| + | |||
| + | function frameLoop() { | ||
| + | if (lastPosition == window.pageYOffset) { // Avoid overcalculations | ||
| + | window.requestAnimationFrame(frameLoop); | ||
| + | return false; | ||
| + | } else lastPosition = window.pageYOffset; | ||
| + | |||
| + | self.render(); | ||
| + | window.requestAnimationFrame(frameLoop); | ||
| + | } | ||
| + | |||
| + | frameLoop(); | ||
| + | }, | ||
| + | |||
| + | configure: function(options) { | ||
| + | if (typeof options == 'object') { | ||
| + | delete options.refresh; | ||
| + | delete options.render; | ||
| + | $.extend(this.prototype, options); | ||
| + | } | ||
| + | }, | ||
| + | |||
| + | refresh: function() { | ||
| + | $.each(this.sliders, function(){ this.refresh(); }); | ||
| + | this.isFresh = true; | ||
| + | }, | ||
| + | |||
| + | render: function() { | ||
| + | this.isFresh || this.refresh(); | ||
| + | $.each(this.sliders, function(){ this.render(); }); | ||
| + | }, | ||
| + | |||
| + | requestRender: function() { | ||
| + | var self = this; | ||
| + | self.render(); | ||
| + | self.isBusy = false; | ||
| + | }, | ||
| + | destroy: function(el){ | ||
| + | var i, | ||
| + | parallaxElement = $(el).data('px.parallax'); | ||
| + | parallaxElement.$mirror.remove(); | ||
| + | for(i=0; i < this.sliders.length; i+=1){ | ||
| + | if(this.sliders[i] == parallaxElement){ | ||
| + | this.sliders.splice(i, 1); | ||
| + | } | ||
| + | } | ||
| + | $(el).data('px.parallax', false); | ||
| + | if(this.sliders.length === 0){ | ||
| + | $(window).off('scroll.px.parallax resize.px.parallax load.px.parallax'); | ||
| + | this.isReady = false; | ||
| + | Parallax.isSetup = false; | ||
| + | } | ||
| + | } | ||
| + | }); | ||
| + | |||
| + | |||
| + | // Parallax Plugin Definition | ||
| + | |||
| + | function Plugin(option) { | ||
| + | return this.each(function () { | ||
| + | var $this = $(this); | ||
| + | var options = typeof option == 'object' && option; | ||
| + | |||
| + | if (this == window || this == document || $this.is('body')) { | ||
| + | Parallax.configure(options); | ||
| + | } | ||
| + | else if (!$this.data('px.parallax')) { | ||
| + | options = $.extend({}, $this.data(), options); | ||
| + | $this.data('px.parallax', new Parallax(this, options)); | ||
| + | } | ||
| + | else if (typeof option == 'object') | ||
| + | { | ||
| + | $.extend($this.data('px.parallax'), options); | ||
| + | } | ||
| + | if (typeof option == 'string') { | ||
| + | if(option == 'destroy'){ | ||
| + | Parallax.destroy(this); | ||
| + | }else{ | ||
| + | Parallax[option](); | ||
| + | } | ||
| + | } | ||
| + | }); | ||
| + | } | ||
| + | |||
| + | var old = $.fn.parallax; | ||
| + | |||
| + | $.fn.parallax = Plugin; | ||
| + | $.fn.parallax.Constructor = Parallax; | ||
| + | |||
| + | |||
| + | // Parallax No Conflict | ||
| + | |||
| + | $.fn.parallax.noConflict = function () { | ||
| + | $.fn.parallax = old; | ||
| + | return this; | ||
| + | }; | ||
| + | |||
| + | |||
| + | // Parallax Data-API | ||
| + | |||
| + | $( function () { | ||
| + | $('[data-parallax="scroll"]').parallax(); | ||
| + | }); | ||
| + | |||
| + | }(jQuery, window, document)); | ||
| + | |||
| + | </script> | ||
<script> | <script> | ||
// When the user scrolls down 20px from the top of the document, show the button | // When the user scrolls down 20px from the top of the document, show the button | ||
Revision as of 15:59, 29 July 2018
<!DOCTYPE html>
Abstract
Recent research studies of Amyotrophic Lateral Sclerosis (ALS) suggest that brain cells that have become toxic, directly contribute to the progression of the disease. These cells change their gene expression pattern and possess distinguishing genetic markers. In addition, they drive the death of other cells in the brain among them the motor neurons.
Our objective, as the BGU-IGEM team OriginALS, is to prolong survival of ALS patients via a novel genetic engineering approach. In order to reach this objective, we combine two separate strategies as our therapeutic approach:
- We identify and selectively eliminate only the toxic cells. In order to identify and target the toxic-cells only, we use distinguishing markers that are unique only to them.
- We prevent the generation of new toxic cells by genetically targeting specific molecules that generate the toxic cells.
In conclusion, our approach combines an apoptotic destruction of toxic cells with the prevention of the formation of new toxic cells, thus aiming to significantly reduce the occurrence of toxic cells in the central neuronal system (CNS), which is aimed at a significant deceleration of the progression rate of ALS.