Difference between revisions of "Team:Bielefeld-CeBiTec/Accumulation"

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                   <h2>Overview</h2>
 
                   <h2>Overview</h2>
 
                   <br><br>
 
                   <br><br>
 +
                  <article>
 
One important goal of nanoFactory is to create an efficient accumulation system for heavy metal                        ions, in this case of copper, in order to subsequently form nanoparticles in <i>Escherichia coli</i>. The main component for such a system is a highly efficient uptake system.
 
One important goal of nanoFactory is to create an efficient accumulation system for heavy metal                        ions, in this case of copper, in order to subsequently form nanoparticles in <i>Escherichia coli</i>. The main component for such a system is a highly efficient uptake system.
  
 
Since copper is toxic to all types of cells (Ladomersky & Petris, 2015), the presence of transporters for the active and selective uptake of copper ions may initially come as a surprise. But copper also carries out important functions in many cells. As a cofactor for many different enzymes such as superoxide dismutase, it is primarily involved in electron transfer and dioxygen transport and activation (Solomon <i>et al.</i>, 2014). Accordingly, there must be natural absorption mechanisms for this trace element into both the periplasm and the cytoplasm. Nevertheless non-bonded, dissolved copper in particular is very toxic, so there are also efficient export systems in <i>E. coli</i> to get rid of excess copper (Rensing & Grass, 2003). In order to create an efficient accumulation system for copper ions, efficient and selective uptake systems must be expressed on the one hand and existing export systems must be suppressed on the other.
 
Since copper is toxic to all types of cells (Ladomersky & Petris, 2015), the presence of transporters for the active and selective uptake of copper ions may initially come as a surprise. But copper also carries out important functions in many cells. As a cofactor for many different enzymes such as superoxide dismutase, it is primarily involved in electron transfer and dioxygen transport and activation (Solomon <i>et al.</i>, 2014). Accordingly, there must be natural absorption mechanisms for this trace element into both the periplasm and the cytoplasm. Nevertheless non-bonded, dissolved copper in particular is very toxic, so there are also efficient export systems in <i>E. coli</i> to get rid of excess copper (Rensing & Grass, 2003). In order to create an efficient accumulation system for copper ions, efficient and selective uptake systems must be expressed on the one hand and existing export systems must be suppressed on the other.
 +
                  </article>
  
 
                   <h2>Import</h2>
 
                   <h2>Import</h2>

Revision as of 16:08, 29 July 2018

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Copper Accumulation System

Overview



One important goal of nanoFactory is to create an efficient accumulation system for heavy metal ions, in this case of copper, in order to subsequently form nanoparticles in Escherichia coli. The main component for such a system is a highly efficient uptake system. Since copper is toxic to all types of cells (Ladomersky & Petris, 2015), the presence of transporters for the active and selective uptake of copper ions may initially come as a surprise. But copper also carries out important functions in many cells. As a cofactor for many different enzymes such as superoxide dismutase, it is primarily involved in electron transfer and dioxygen transport and activation (Solomon et al., 2014). Accordingly, there must be natural absorption mechanisms for this trace element into both the periplasm and the cytoplasm. Nevertheless non-bonded, dissolved copper in particular is very toxic, so there are also efficient export systems in E. coli to get rid of excess copper (Rensing & Grass, 2003). In order to create an efficient accumulation system for copper ions, efficient and selective uptake systems must be expressed on the one hand and existing export systems must be suppressed on the other.

Import

Export

Figure X:
Firstname Lastname Age
Jill Smith 50
Eve Jackson 94
John Doe 80

References

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