Line 50: | Line 50: | ||
<article> | <article> | ||
− | Fe(III) and Fe(II) are important cofactors used in the active sites of a broad range of enzymes. Therefore, the iron homeostasis is a process tightly controlled in all organisms. Metal ions can also have toxic side effects when the amount of free ions inside the cell is too high because copper and iron ions can catalyse the formation of reactive oxygen species (ROS) which are highly toxic to the cell. For this reason we measured the toxicity of different ion concentrations and searched for countermeasures (see <a href | + | Fe(III) and Fe(II) are important cofactors used in the active sites of a broad range of enzymes. Therefore, the iron homeostasis is a process tightly controlled in all organisms. Metal ions can also have toxic side effects when the amount of free ions inside the cell is too high because copper and iron ions can catalyse the formation of reactive oxygen species (ROS) which are highly toxic to the cell. For this reason we measured the toxicity of different ion concentrations and searched for countermeasures (see <a href="https://2018.igem.org/Team:Bielefeld-CeBiTec/Toxicity_Theory"> Toxicity</a>). </br> |
To prohibit toxic side effects the efflux and influx of ions are tightly controlled by a set of regulators, importers, exporters and storage proteins. | To prohibit toxic side effects the efflux and influx of ions are tightly controlled by a set of regulators, importers, exporters and storage proteins. |
Revision as of 14:58, 29 August 2018
/* HQ CSS*/ .firstHeading { display: none; }
.mw-content-text { display: none; }
.logo_2018 { display: none; }
- globalWrapper {
padding: 0px; margin: 0px; padding-bottom: 0px; }
- content {
margin-left:0px; padding:0px; width:100%; margin-top: -7px; }
.mw-content-ltr ul, .mw-content-rtl .mw-content-ltr ul{ margin:0px; }
- top_title {
margin-bottom: 0px; }
- top_menu_14{
border-bottom: 0px solid black; }
- HQ_page p {
margin: 0; }
/*NAVBAR*/
@charset "UTF-8";
body{ margin-top:0px; }
.navigation { height: 70px; background: #002a5c; position: fixed; width:100%; text-decoration: none; }
.brand { position: absolute; padding-left: 20px; float: left; line-height: 70px; text-transform: uppercase; font-size: 1.4em; width: 300px; }
.logo-img{ width: 70%; margin-top: 1%; }
@media only screen and (max-width: 1350px) { .logo-img{ width: 70%; margin-top: 2%; }
.navigation{ position: absolute; }
}
@media only screen and (max-width: 790px) { .logo-img{ width: 70%; margin-top: 3%; }
.navigation{ position: absolute; }
}
.brand a,
.brand a:visited {
color: #ffffff;
text-decoration: none;
}
.nav-container { max-width: auto; margin: 0 auto; text-decoration: none; }
nav { float: right; text-decoration: none; } nav ul { list-style: none; margin: 0; padding: 0; text-decoration: none; } nav ul li { float: left; position: relative; text-decoration: none; } nav ul li a, nav ul li a:visited, nav ul li a:focus{ display: block; padding: 0 20px; line-height: 70px; background: #002a5c; color: #ffffff; text-decoration: none; margin-bottom:-4px; border-color:#002a5c; } nav ul li a:hover, nav ul li a:visited:hover { background: #4d9dff; color: #ffffff; text-decoration: none; } nav ul li a:not(:only-child):after, nav ul li a:visited:not(:only-child):after { padding-left: 4px; content: " ▾"; text-decoration: none; } nav ul li ul li { min-width: 190px; text-decoration: none; } nav ul li ul li a { padding: 15px; line-height: 20px; text-decoration: none; text-decoration: none; }
.nav-dropdown { position: absolute; display: none; z-index: 1; box-shadow: 0 3px 12px rgba(0, 0, 0, 0.15); text-decoration: none; }
/* Mobile navigation */ .nav-mobile { display: none; position: absolute; top: 0; right: 0; background: #002a5c; height: 70px; width: 70px; }
@media only screen and (max-width: 1350px) {
.nav-mobile {
display: block;
}
nav { width: 100%; padding: 70px 0 15px; } nav ul { display: none; max-height: 280px; overflow-y: auto; } nav ul li { float: none; } nav ul li a { padding: 15px; line-height: 20px; text-decoration: none; } nav ul li ul li a { padding-left: 30px; text-decoration: none; }
.nav-dropdown { position: static; } } @media screen and (min-width: 1351px) { .nav-list { display: block !important; } }
- nav-toggle {
position: absolute; left: 18px; top: 22px; cursor: pointer; padding: 10px 35px 16px 0px; max-height: 280px; overflow-y: auto; }
- nav-toggle span,
- nav-toggle span:before,
- nav-toggle span:after {
cursor: pointer; border-radius: 1px; height: 5px; width: 35px; background: #ffffff; position: absolute; display: block; content: ""; transition: all 300ms ease-in-out; }
- nav-toggle span:before {
top: -10px; }
- nav-toggle span:after {
bottom: -10px; }
- nav-toggle.active span {
background-color: transparent; }
- nav-toggle.active span:before, #nav-toggle.active span:after {
top: 0; }
- nav-toggle.active span:before {
transform: rotate(45deg); }
- nav-toggle.active span:after {
transform: rotate(-45deg); }
article { max-width: 1000px; margin: 0 auto; padding: 10px; line-height: 1.5; }
.article { max-width: 1000px; margin: 0 auto; padding: 10px; line-height: 1.5; padding-right: 5%; padding-left : 5%;
}
/* W3 Schools templates*/
.w3-top,.w3-bottom{position:fixed;width:100%;z-index:1;} .w3-top{top:0;} .w3-bottom{bottom:0;}
- footer{display:block;width:98%}
.w3-container:after,.w3-container:before{content:"";display:table;clear:both;width:98%;}
.w3-container{}
.w3-padding-32{padding-top:32px!important;padding-bottom:32px!important;}
.w3-center .w3-bar{display:inline-block;width:auto;}
.w3-center{text-align:center!important;}
.w3-black,.w3-hover-black:hover{color:#fff!important;background-color:#000!important;}
.w3-xlarge{font-size:24px!important;}
/*OWN STYLES*/
body { font-family: "Lato", sans-serif; }
@media only screen and (min-width: 1010px){ .main_content {
background-color: white; border: 1px solid #000000; border-radius: 0px; box-shadow: 1px 1px 3px rgba(0, 0, 0, 0.35); min-height: 100px; border-top: none; border-bottom: none; margin-left:25%; margin-right:25%; padding-bottom: 4%; min-height: 420px; position: sticky; margin-top: -100px; } }
@media only screen and (max-width: 1009px){ .main_content {
background-color: white; border: 1px solid #000000; border-radius: 0px; box-shadow: 1px 1px 3px rgba(0, 0, 0, 0.35); min-height: 100px; border-top: none; border-bottom: none; margin-left:0; margin-right:0; padding-bottom: 4%; position: sticky; margin-top: -100px; } }
- container{
position: relative; min-height: 100%; height: 100%; }
.container{ padding-top:0px; background-color: #001633; }
.section{ margin: 1%; }
.half{ max-width: 48%; }
.half.left { float: left; margin-right: 1%; }
.half.right { float: right; margin-left: 1%;
}
article, .article { text-align: justify; display: block; margin: auto; font-size: 16px; padding-bottom: 20px; }
article, .article, .contentline { width: 90%; font-size: 16px; padding-bottom: 30px; }
.contentline article, .contentline .article { width: 100%; }
h1, h2, h3, h4, h5, h6 { width: 92%; margin: auto; margin-top: 0px; padding-top: 20px; padding-bottom: 15px; }
.p { text-align: justify; }
.title { font-size: 40px; padding-top: 5%; padding-left: 3%; padding-bottom: 40px; font-weight: bold; background-color: rgb(255,255,255); margin-top: -70px; position:sticky; line-height:1.5em; text-align:left; }
h2 { padding-left: 3%; font-size:14; }
br { display: block; /* makes it have a width */ content: ""; /* clears default height */ margin-top: 20px; /* change this to whatever height you want it */ }
p { font-size:14px; }
body { padding-top: 0px; }
article{
padding-right: 5%;
padding-left : 5%;
}
- page-arrow-top {
display: none; cursor: pointer; padding: 0; margin: 0; position: fixed; bottom: 20px; right: 50px; }
.half { width: 48%; }
.half.left { float: left; margin-right: 1%; }
.half.right { float: right; margin-left: 1%; }
.sidenavi{
margin-top: 50px; margin-left: 4%; display: block; position: -webkit-sticky; position: sticky; top: 150px; float: left; background-color: #001633; border-radius: 30px; border-color: white; border-style: solid; }
.side_list{
display: block;
margin-right: 10px;
margin-bottom: 15px;
margin-top: 10px;
margin-left: 10px;
color: white;
}
.side_link{ color: white; font-size: 20px; text-decoration:none; padding: 10px; }
.side_list > a:hover{ text-decoration:none; color: white; }
.side_list > a{ text-decoration:none; font-size: 18px; padding: 10px; width:100%; cursor: pointer; color: white; }
@media only screen and (max-width: 1150px){
.sidenavi{
margin-top: 50px; margin-left: 1%; display: block; position: -webkit-sticky; position: sticky; top: 150px; float: left; background-color: #001633; border-radius: 30px; border-color: white; border-style: solid; }
.side_list{ display: block; margin-right: 10px; margin-bottom: 15px; margin-top: 10px; margin-left: 10px; color: white; }
.side_link{ color: white; font-size: 10px; text-decoration:none; padding: 10px; }
.side_list > a:hover{ text-decoration:none; color: white; }
.side_list > a{ text-decoration:none; font-size: 16px; padding: 12px; width:100%; cursor: pointer; color: white; }
}
@media only screen and (max-width: 1685px){
.sidenavi{
margin-top: 50px; margin-left: 1%; display: block; position: -webkit-sticky; position: sticky; top: 150px; float: left; background-color: #001633; border-radius: 30px; border-color: white; border-style: solid; }
.side_list{ display: block; margin-right: 10px; margin-bottom: 15px; margin-top: 10px; margin-left: 10px; color: white; }
.side_link{ color: white; font-size: 10px; text-decoration:none; padding: 10px; }
.side_list > a:hover{ text-decoration:none; color: white; }
.side_list > a{ text-decoration:none; font-size: 16px; padding: 8px; width:100%; cursor: pointer; color: white; }
}
@media only screen and (max-width: 1300px){
.sidenavi{
display: none;
} }
figure {
text-align: center;
margin-bottom: 30px;
}
figcaption{ text-align: justify; font-size: 13px; margin-top:10px; }
.figure.eighty { width:80%; }
.figure.ten { width:10%; }
.figure.twenty { width:20%; }
.figure.thirty { width:30%; }
.figure.fourty { width:40%; }
.figure.fifty { width:50%; }
.figure.sixty { width:60%; }
.figure.seventy { width:70%; }
.figure.ninety { width:90%; }
.figure.hundred { width:100%; }
table, th, td {
border: 1px solid black;
border-collapse: collapse;
font-size:17px;
}
th, td {
padding: 15px;
text-align: left;
}
table#t01 tr:first-child td{
background-color: #eee;
}
table#t01 tr td:first-child { background-color: #eee; color: black; }
table.centern{
margin-left:15%;
margin-right:15%;
margin-top: 100px;
margin-top: 5%;
}
- HQ_page table {
border: 1px solid #ccc; border-collapse: collapse; width: 70%; margin: auto; margin-bottom: 0px; margin-top: 100px; margin-right: auto; margin-left: auto; }
hr { margin-top: 10%; margin-bottom: 20px; border: 0; text-align: center; border-top: 2px solid #000000; margin-left: auto; margin-right: auto;
}
.reftext { display: block; text-align: justify; margin-left: 5%; margin-right: 5%; font-size: 14px; padding-bottom: 20px; line-height: 20px; }
/*Footer*/ .fa-facebook-official:before { content: "\f230"; color: white; }
.fa-instagram:before {
content: "\f230";
color: white;
}
.fa-twitter:before { content: "\f230"; color: white; }
- myDIV {
margin-top: 10px; display:none; }
.refbtn{ background-color: white; border: none; font-size: 150%; font-weight: bold; color: black; margin-left: 5%; margin-bottom: 26px; margin-top: 30px;
}
a.shifted-anchor { display: block; position:relative; top: -100px; }
- active{
text-decoration: none; }
html,body { background-color: #001633; }
- myVideo {
position: static; top:0; left:0 right: 0; bottom: 0; height: auto; margin-top: 70px; z-index:1; }
.title_picture{
width:100%;
padding-top:40px;
}
@-webkit-keyframes animateBubble {
0% {
margin-top: 310%;
}
100% {
margin-top: 5%;
}
}
@-moz-keyframes animateBubble { 0% { margin-top: 310%; } 100% { margin-top: 5%; } }
@keyframes animateBubble { 0% { margin-top: 310%; } 100% { margin-top: 5%; } }
@-webkit-keyframes animateBubbleSeite { 0% { margin-top: 40px; } 100% { margin-top: -200%; } }
@-moz-keyframes animateBubbleSeite { 0% { margin-top: 40px; } 100% { margin-top: -200%; } }
@keyframes animateBubbleSeite { 0% { margin-top: 40px; } 100% { margin-top: -200%; } }
@-webkit-keyframes sideWays {
0% {
margin-left:0px;
}
100% {
margin-left:50px;
}
}
@-moz-keyframes sideWays { 0% { margin-left:0px; } 100% { margin-left:50px; } }
@keyframes sideWays { 0% { margin-left:0px; } 100% { margin-left:50px; } }
.s1 {
-webkit-animation: animateBubbleSeite 120s linear infinite, sideWays 2s ease-in-out infinite alternate;
-moz-animation: animateBubbleSeite 120s linear infinite, sideWays 2s ease-in-out infinite alternate;
animation: animateBubbleSeite 120s linear infinite, sideWays 2s ease-in-out infinite alternate;
left: 5%; top: 95%; z-index:1; overflow: hidden;
-webkit-transform: scale(0.1); -moz-transform: scale(0.1); transform: scale(0.1); }
.x1 { -webkit-animation: animateBubble 100s linear infinite, sideWays 2s ease-in-out infinite alternate; -moz-animation: animateBubble 100s linear infinite, sideWays 2s ease-in-out infinite alternate; animation: animateBubble 100s linear infinite, sideWays 2s ease-in-out infinite alternate;
left: -5%; top: 20%; z-index:1; overflow: hidden;
-webkit-transform: scale(0.1); -moz-transform: scale(0.1); transform: scale(0.1); }
.x2 { -webkit-animation: animateBubble 80s linear infinite, sideWays 4s ease-in-out infinite alternate; -moz-animation: animateBubble 80s linear infinite, sideWays 4s ease-in-out infinite alternate; animation: animateBubble 80s linear infinite, sideWays 4s ease-in-out infinite alternate;
left: 5%; top: 20%; z-index:1; overflow: hidden; -webkit-transform: scale(0.2); -moz-transform: scale(0.2); transform: scale(0.2); }
.x3 { -webkit-animation: animateBubble 120s linear infinite, sideWays 2s ease-in-out infinite alternate; -moz-animation: animateBubble 120s linear infinite, sideWays 2s ease-in-out infinite alternate; animation: animateBubble 120s linear infinite, sideWays 2s ease-in-out infinite alternate;
left: 10%; top: 20%; overflow: hidden; z-index:1; -webkit-transform: scale(0.2); -moz-transform: scale(0.2); transform: scale(0.2); }
.x4 { -webkit-animation: animateBubble 90s linear infinite, sideWays 3s ease-in-out infinite alternate; -moz-animation: animateBubble 90s linear infinite, sideWays 3s ease-in-out infinite alternate; animation: animateBubble 90s linear infinite, sideWays 3s ease-in-out infinite alternate;
left: 20%; top: 20%; overflow: hidden; z-index:1; -webkit-transform: scale(0.2); -moz-transform: scale(0.2); transform: scale(0.2); }
.x5 { -webkit-animation: animateBubble 70s linear infinite, sideWays 4s ease-in-out infinite alternate; -moz-animation: animateBubble 70s linear infinite, sideWays 4s ease-in-out infinite alternate; animation: animateBubble 70s linear infinite, sideWays 4s ease-in-out infinite alternate;
left: 30%; top: 20%; overflow: hidden; z-index:1; -webkit-transform: scale(0.1); -moz-transform: scale(0.1); transform: scale(0.1); }
.x6 { -webkit-animation: animateBubble 115s linear infinite, sideWays 2s ease-in-out infinite alternate; -moz-animation: animateBubble 115s linear infinite, sideWays 2s ease-in-out infinite alternate; animation: animateBubble 115s linear infinite, sideWays 2s ease-in-out infinite alternate;
left: 50%; top: 20%; overflow: hidden; z-index:1; -webkit-transform: scale(0.1); -moz-transform: scale(0.1); transform: scale(0.1); }
.x7 { -webkit-animation: animateBubble 120s linear infinite, sideWays 2s ease-in-out infinite alternate; -moz-animation: animateBubble 120s linear infinite, sideWays 2s ease-in-out infinite alternate; animation: animateBubble 120s linear infinite, sideWays 2s ease-in-out infinite alternate;
left: 65%; top: 20%; overflow: hidden; z-index:1; -webkit-transform: scale(0.1); -moz-transform: scale(0.1); transform: scale(0.1); }
.x8 { -webkit-animation: animateBubble 100s linear infinite, sideWays 3s ease-in-out infinite alternate; -moz-animation: animateBubble 100s linear infinite, sideWays 3s ease-in-out infinite alternate; animation: animateBubble 100s linear infinite, sideWays 3s ease-in-out infinite alternate;
left: 80%; top: 20%; overflow: hidden; z-index:1; -webkit-transform: scale(0.2); -moz-transform: scale(0.2); transform: scale(0.2); }
.x9 { -webkit-animation: animateBubble 80s linear infinite, sideWays 4s ease-in-out infinite alternate; -moz-animation: animateBubble 80s linear infinite, sideWays 4s ease-in-out infinite alternate; animation: animateBubble 80s linear infinite, sideWays 4s ease-in-out infinite alternate;
left: 90%; top: 20%; overflow: hidden; z-index:1; -webkit-transform: scale(0.1); -moz-transform: scale(0.1); transform: scale(0.1); }
.x10 { -webkit-animation: animateBubble 120s linear infinite, sideWays 2s ease-in-out infinite alternate; -moz-animation: animateBubble 120s linear infinite, sideWays 2s ease-in-out infinite alternate; animation: animateBubble 120s linear infinite, sideWays 2s ease-in-out infinite alternate;
left: 80%; top: 20%; overflow: hidden; z-index:1; -webkit-transform: scale(0.1); -moz-transform: scale(0.1); transform: scale(0.1); }
.bubble {
-webkit-border-radius: 50%;
-moz-border-radius: 50%;
border-radius: 50%;
-webkit-box-shadow: 0 20px 30px rgba(0, 0, 0, 0.2), inset 0px 10px 30px 5px rgba(255, 255, 255, 1); -moz-box-shadow: 0 20px 30px rgba(0, 0, 0, 0.2), inset 0px 10px 30px 5px rgba(255, 255, 255, 1); box-shadow: 0 20px 30px rgba(0, 0, 0, 0.2), inset 0px 10px 30px 5px rgba(255, 255, 255, 1);
height: 200px; position: absolute; width: 200px; }
.bubble:after { background: -moz-radial-gradient(center, ellipse cover, rgba(255,255,255,0.5) 0%, rgba(255,255,255,0) 0%); /* FF3.6+ */ background: -webkit-gradient(radial, center center, 0px, center center, 100%, color-stop(0%,rgba(255,255,255,0.5)), color-stop(0%,rgba(255,255,255,0))); /* Chrome,Safari4+ */ background: -webkit-radial-gradient(center, ellipse cover, rgba(255,255,255,0.5) 0%,rgba(255,255,255,0) 0%); /* Chrome10+,Safari5.1+ */ background: -o-radial-gradient(center, ellipse cover, rgba(255,255,255,0.5) 0%,rgba(255,255,255,0) 0%); /* Opera 12+ */ background: -ms-radial-gradient(center, ellipse cover, rgba(255,255,255,0.5) 0%,rgba(255,255,255,0) 0%); /* IE10+ */ background: radial-gradient(ellipse at center, rgba(255,255,255,0.5) 0%,rgba(255,255,255,0) 0%); /* W3C */ filter: progid:DXImageTransform.Microsoft.gradient( startColorstr='#80ffffff', endColorstr='#00ffffff',GradientType=1 ); /* IE6-9 fallback on horizontal gradient */
-webkit-border-radius: 50%; -moz-border-radius: 50%; border-radius: 50%;
-webkit-box-shadow: inset 0 20px 30px rgba(255, 255, 255, 0.3); -moz-box-shadow: inset 0 20px 30px rgba(255, 255, 255, 0.3); box-shadow: inset 0 20px 30px rgba(255, 255, 255, 0.3);
content: ""; height: 180px; left: 10px; position: absolute; width: 180px; }
@media only screen and (max-width: 1700px) {
.bubble.x1, .bubble.x2, .bubble.x8, .bubble.x9, .bubble.x10{ display:none; }
}
@media only screen and (max-width: 1200px) {
.bubble.x1, .bubble.x2, .bubble.x7, .bubble.x8, .bubble.x9, .bubble.x10{ display:none; } }
.timer_box{
border: white; border-style: solid; padding-bottom: 125px; padding-left: 10px; padding_top:10px; marging-bottom: 100px;
}
- gold {
float: left; font-size: 50px; margin-top: 10px; width: 50%; color:white;
text-align: center;
}
- gold_text {
float: left; font-size: 20px; margin-top: 0px; width: 50%; color:white;
text-align: center; }
- silver {
float: left; text-align: center; font-size: 50px; margin-top: 10px; width: 50%; color:white;
}
- silver_text {
float: left; text-align: center; font-size: 20px; margin-top: 0px; width: 50%; color:white;
}
.img_text{ text-align:center; position:absolute; }
- home_imgs {
margin-top:100px; width:60%;
}
@media only screen and (max-width: 1300px) {
- home_imgs{
width:70%;
}
- silver{
font-size: 30px;
}
- gold{
font-size: 30px;
}
- silver_text{
font-size: 20px;
}
- gold_text{
font-size: 20px; }
}
@media only screen and (max-width: 900px) {
.timer_box{
border: white; border-style: solid; padding-bottom: 100px; padding-left: 10px; padding_top:10px; marging-bottom: 100px;
}
- home_imgs{
margin-top:50px; width:90%; }
- silver{
font-size: 20px;
}
- gold{
font-size: 20px;
}
- silver_text{
font-size: 15px;
}
- gold_text{
font-size: 15px; }
}
@media only screen and (max-width: 600px) {
.timer_box{
border: white; border-style: solid; padding-bottom: 100px; padding-left: 10px; padding_top:10px; marging-bottom: 100px;
}
- home_imgs{
margin-top:15px; width:100%; }
- silver{
font-size: 15px;
}
- gold{
font-size: 15px;
}
- silver_text{
font-size: 10px;
}
- gold_text{
font-size: 10px; }
}
@media only screen and (max-width: 400px) {
.timer_box{
border: white; border-style: solid; padding-bottom: 50px; padding-left: 10px; padding_top:10px; marging-bottom: 100px;
}
- home_imgs{
margin-top:5px; width:100%; }
- silver{
font-size: 10px;
}
- gold{
font-size: 10px;
}
- silver_text{
font-size: 5px;
}
- gold_text{
font-size: 5px; }
}