Difference between revisions of "Team:CIEI-BJ/Design"

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<h1>Design</h1>
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Design is the first step in the design-build-test cycle in engineering and synthetic biology. Use this page to describe the process that you used in the design of your parts. You should clearly explain the engineering principles used to design your project.
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This page is different to the "Applied Design Award" page. Please see the <a href="https://2018.igem.org/Team:CIEI-BJ/Applied_Design">Applied Design</a> page for more information on how to compete for that award.
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<li><a href="#a1">Background</a>
 
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<h3>What should this page contain?</h3>
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<li>Explanation of the engineering principles your team used in your design</li>
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<li><a href="#a2">What Is Aflatoxin</a>
<li>Discussion of the design iterations your team went through</li>
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<li>Experimental plan to test your designs</li>
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<li><a href="#a3">Aflatoxin Contamination</a>
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<li><a href="#a4">Aflatoxin and Our Health</a>
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<li><a href="#a5">Aflatoxin impact on a global scale</a>
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<h3>Inspiration</h3>
 
<ul>
 
<li><a href="https://2016.igem.org/Team:MIT/Experiments/Promoters">2016 MIT</a></li>
 
<li><a href="https://2016.igem.org/Team:BostonU/Proof">2016 BostonU</a></li>
 
<li><a href="https://2016.igem.org/Team:NCTU_Formosa/Design">2016 NCTU Formosa</a></li>
 
 
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<div class="first-level" id="a1"  >Background</div>
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<div class="second-level" id="a2" >What Is Aflatoxin</div>
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<p class="my-content" >Aflatoxin is toxic secondary metabolites produced by Aspergillus fungi and Aspergillus parasiticus. AFB1 is the most potent and potentially lethal metabolite and is a known human carcinogen. Aflatoxin are abundant in warm and humid regions, consequently contaminating crops at harvest and during storage. Once the crops were contaminated, the aflatoxin cannot be removed through normal process of cooking.</p>
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<img class="my-img" src="https://static.igem.org/mediawiki/2018/c/cd/T--CIEI-BJ--Project--Background--fig1.png" />
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<img class="my-img" src="https://static.igem.org/mediawiki/2018/2/24/T--CIEI-BJ--Project--Background--fig2.png" />
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<div class="second-level" id="a3" >Aflatoxin Contamination</div>
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<p class="my-content" >Aflatoxin are abundant especially in warm and humid regions. They can contaminate crops at harvest and during storage. Once the crops are contaminated, the aflatoxin in those crops can not be removed by cooking or degraded by our body.</p>
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<img class="my-img" src="https://static.igem.org/mediawiki/2018/4/47/T--CIEI-BJ--Project--Background--fig3.png" />
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<p class="my-content" >Our everyday commodities such as corn, peanut, pistachio, coconut, soybean, rice etc. are all prone to aflatoxin contamination. Aflatoxin in those products will then be ingested by us, after directly eating the products. Since animal body cannot degrade aflatoxin, the aflatoxin in animals will be transferred to us if we consume any product from those animals.</p>
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<img class="my-img" src="https://static.igem.org/mediawiki/2018/6/6f/T--CIEI-BJ--Project--Background--fig4.png" />
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<div class="second-level" id="a4" >Aflatoxin and Our Health</div>
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<p class="my-content" >Furthermore, ingesting small amount of aflatoxin not enough to cause aflatoxicosis would also bring life threatening risks for a long period of time. The consequence of chronic aflatoxin exposure will lead to a deadly disease, hepatocellular carcinoma (liver cancer). Pregnant woman who suffer from chronic aflatoxin exposure might pass on the toxic aflatoxin to their babies. These new born babies will suffer from stunted growth and immune suppression.</p>
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<img class="my-img" src="https://static.igem.org/mediawiki/2018/e/e0/T--CIEI-BJ--Project--Background--fig5.png" />
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<p class="my-content" >A causative role in 4.6–28.2% of all global HCC cases</p>
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<p class="my-content" >Toxicity of aflatoxin mainly targets our liver, causing substantial damage to the liver. Ingesting large amount of aflatoxin will lead to aflatoxin poisoning called aflatoxicosis, and the case fatality rate of aflatoxicosis is 25%. Related symptoms could be: vomiting, abdominal pain, pulmonary edema, convulsions and coma. Severe aflatoxicosis might lead to death with cerebral edema and fatty involvement of the liver, kidneys and heart. It was estimated that approximately 10 to 20 mg of aflatoxin will kill an adult.</p>
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<div class="second-level" id="a5" >Aflatoxin impact on a global scale</div>
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<p class="my-content" >Aflatoxin are slowly affecting people from all around the world, especially developing and underdeveloped countries which haven’t enforce regulations on aflatoxin in crops due to financial reasons.</p>
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<p class="my-content" >In 2004, the aflatoxicosis outbreak in Kenya was one of the most severe episodes of human aflatoxin poisoning in history. Total cases reported was 317 and the fatality rate was 39%.</p>
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<img class="my-img" src="https://static.igem.org/mediawiki/2018/c/c0/T--CIEI-BJ--Project--Background--fig6.png" />
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<p class="my-content" >However, chronic exposure to aflatoxin might bring risks to people on a larger scale. Over 55 billion people worldwide are at risk of uncontrolled exposure to aflatoxin.</p>
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<img class="my-img" src="https://static.igem.org/mediawiki/2018/c/cf/T--CIEI-BJ--Project--Background--fig7.png" />
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<p class="my-content" >Of the 550,000–600,000 new HCC cases worldwide each year, about 25,200–155,000 may be attributable to aflatoxin exposure.</p>
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Revision as of 05:16, 8 October 2018

Top
Background
What Is Aflatoxin

Aflatoxin is toxic secondary metabolites produced by Aspergillus fungi and Aspergillus parasiticus. AFB1 is the most potent and potentially lethal metabolite and is a known human carcinogen. Aflatoxin are abundant in warm and humid regions, consequently contaminating crops at harvest and during storage. Once the crops were contaminated, the aflatoxin cannot be removed through normal process of cooking.

Aflatoxin Contamination

Aflatoxin are abundant especially in warm and humid regions. They can contaminate crops at harvest and during storage. Once the crops are contaminated, the aflatoxin in those crops can not be removed by cooking or degraded by our body.

Our everyday commodities such as corn, peanut, pistachio, coconut, soybean, rice etc. are all prone to aflatoxin contamination. Aflatoxin in those products will then be ingested by us, after directly eating the products. Since animal body cannot degrade aflatoxin, the aflatoxin in animals will be transferred to us if we consume any product from those animals.

Aflatoxin and Our Health

Furthermore, ingesting small amount of aflatoxin not enough to cause aflatoxicosis would also bring life threatening risks for a long period of time. The consequence of chronic aflatoxin exposure will lead to a deadly disease, hepatocellular carcinoma (liver cancer). Pregnant woman who suffer from chronic aflatoxin exposure might pass on the toxic aflatoxin to their babies. These new born babies will suffer from stunted growth and immune suppression.

A causative role in 4.6–28.2% of all global HCC cases

Toxicity of aflatoxin mainly targets our liver, causing substantial damage to the liver. Ingesting large amount of aflatoxin will lead to aflatoxin poisoning called aflatoxicosis, and the case fatality rate of aflatoxicosis is 25%. Related symptoms could be: vomiting, abdominal pain, pulmonary edema, convulsions and coma. Severe aflatoxicosis might lead to death with cerebral edema and fatty involvement of the liver, kidneys and heart. It was estimated that approximately 10 to 20 mg of aflatoxin will kill an adult.

Aflatoxin impact on a global scale

Aflatoxin are slowly affecting people from all around the world, especially developing and underdeveloped countries which haven’t enforce regulations on aflatoxin in crops due to financial reasons.

In 2004, the aflatoxicosis outbreak in Kenya was one of the most severe episodes of human aflatoxin poisoning in history. Total cases reported was 317 and the fatality rate was 39%.

However, chronic exposure to aflatoxin might bring risks to people on a larger scale. Over 55 billion people worldwide are at risk of uncontrolled exposure to aflatoxin.

Of the 550,000–600,000 new HCC cases worldwide each year, about 25,200–155,000 may be attributable to aflatoxin exposure.