Team:NUDT CHINA/Model/Basic Design

Designed Protein Degradation Method Based on

Trim21 And Nanobody

Basic Work

Introduction

Compared with general model whose circuit directly express the protein and functions, the construction of model is not complicated. Our trim21-antibody system needs to bind to target protein after expressing trim21 and antibody to complete the task. So we made the following design for the model:As is shown in the flow chart, we split the whole process into three parts: the plasmid expresses GFP antibody and trim21, antibody binds to antigen, the ubiquitination by Trim21 to the final degradation, which are connected by bridges (concentration of antibody and complex).Then the final ODE equations are constructed.

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More details

Question 1: What does the structure of domains look like?

There are several variants of derived from different organisms. In our project, we . The structure of this protein has been determined with and without The a lobe. The two lobes are positively charged towards the protein core to accommodate the negatively charged RNA. Each of these two lobes contains an RNase domain. At the main is responsible for target cleavage. In contrast to other two RNase domains of the NUC lobe are located at the outside of the protein, which is likely the reason collateral cleavage upon activation by binding to a matching target. These two domains have been labeled as red spots in Figure 2 and can be found at the interface between the green and pink domain.

Collapsible Group Item #2

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