Team:Bielefeld-CeBiTec/Description

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  • Toxicity
  • Accumulation
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Project Overview

This is nanoFactory. A combined system with the goal to clean up mining drainage and produce nano particles.

Dual Use

Considering Dual Use issues is the principle of considering in which ways the project can be used and misused. After realizing that we never came in touch with this term in our whole academic education we decided to find out more.

Modeling

„Any modeling project should be tempered by the morality of laziness.“ (Barnes et. al., 2010). We model time until cell death, siRNA/RNAi interaction, ferritin characterization and process control parameters for our cross-flow reactor.

Promoter Collection

Due to the lack of data on precise promoter strength data a new measuring system had to be established.

Toxicity

Metal ions cause hydrogen peroxide to form toxic reactive oxygen species. To counteract, new H₂O₂ scavenging BioBricks were needed.

Accumulation

Metal ions need transport proteins to enter the cells. New BioBricks are required to increase the uptake of metal ions to increase the nanoparticle yield.

Silencing

Knocking out copper exporters causes cell death. Precise control over the translation process leads to a better growth condition for the cell.

Nanoparticles

Nanoparticles are materials on nano scale. They show different physical properties and thus, are of high interest for industry, medicine and science.

Reactor

To filter high amounts of mining drainage without releasing GMO into the environment a hardware need to be designed, constructed and optimized.

Proof of Concept

Different applications for nanoparticles received through synthetic biology are investigated.