Difference between revisions of "Team:CPU CHINA"

 
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{{:Team:CPU_CHINA/Templates/NavFoot}}
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<html>
 
<html>
 
<head>
 
<head>
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<script src="https://2018.igem.org/Team:CPU_CHINA/jQuery_script_css?action=raw&ctype=text/javascript"></script>
 
<script src="https://2018.igem.org/Team:CPU_CHINA/jQuery_script_css?action=raw&ctype=text/javascript"></script>
 
<script src="https://2017.igem.org/Team:CPU_CHINA/js/bootstrap?action=raw&amp;ctype=text/javascript"></script>
 
<script src="https://2017.igem.org/Team:CPU_CHINA/js/bootstrap?action=raw&amp;ctype=text/javascript"></script>
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<link rel="stylesheet" href="https://2018.igem.org/Team:CPU_CHINA/bootstrap_style_css?action=raw&ctype=text/css">
+
<link rel="stylesheet" href="https://2018.igem.org/Team:CPU_CHINA/bootstrap_style_css?action=raw&amp;ctype=text/css">
 
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</head>
 
</head>
 
<style>
 
<style>
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.btn-group
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{
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top:2.8%;
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 +
.dropdown-menu{
 +
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div
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{
 +
font-family:"Century Gothic";
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}
 
#content
 
#content
 
{
 
{
 
position:relative;
 
position:relative;
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}
 
}
 
button
 
button
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outline:none;
 
outline:none;
 
}
 
}
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#top_title{
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.footer{
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    display:none !important;
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position: absolute;
 +
top:unset;
 +
bottom: -98px;
 
}
 
}
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#sideMenu{
 
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    display:none !important;
 
−
}
 
−
.img-div p{
 
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    margin: 10px 0 40px 0;
 
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    font-size: 20px !important;
 
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    text-align: center !important;
 
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    font-family: "Century Gothic";
 
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}
 
−
.homej:link{
 
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color:rgb(189,190,176);text-decoration:none;
 
−
}
 
−
.homej:hover{
 
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color:rgb(0,0,0);
 
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}
 
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.homej:visited{
 
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color:rgb(189,190,176);text-decoration:none;
 
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}
 
−
button:hover{background-color:#400080;}
 
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a:visited{color:purple;}
 
−
.mw-content-ltr {
 
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.box{
 
.box{
 
       position: absolute;
 
       position: absolute;
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}
 
}
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  /*@keyframes mymovewheel {
 
       from {}
 
       from {}
 
       to {
 
       to {
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     }
 
     }
  
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     @-moz-keyframes mymove {
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     @-moz-keyframes mymovewheel {
 
       from {}
 
       from {}
 
       to {
 
       to {
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     }
 
     }
  
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     @-webkit-keyframes mymove {
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     @-webkit-keyframes mymovewheel {
 
       from {}
 
       from {}
 
       to {
 
       to {
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     }
 
     }
  
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     @-o-keyframes mymove {
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     @-o-keyframes mymovewheel {
 
       from {}
 
       from {}
 
       to {
 
       to {
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       }
 
       }
 
     }
 
     }
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*/
 
.wheel
 
.wheel
 
{
 
{
 
       position: absolute;
 
       position: absolute;
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       top: 325px;
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       top: 1150px;
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       width: 100px;
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       width: 10%;
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       height: 100px;
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       height: 300px;
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       left:49px;
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       left:11%;
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      animation: rotate 10s infinite;
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−
      -webkit-animation: mymove 10s infinite;
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−
      animation-timing-function: linear;
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       background: url(https://static.igem.org/mediawiki/2018/0/0a/T--CPU_CHINA--background-wheel.png);
 
       background: url(https://static.igem.org/mediawiki/2018/0/0a/T--CPU_CHINA--background-wheel.png);
−
      background-size: 100px 100px;
 
 
       background-repeat: no-repeat;
 
       background-repeat: no-repeat;
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       background-size: cover;
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       background-size: contain;
 
}
 
}
 
.carriage
 
.carriage
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       position: absolute;
 
       position: absolute;
 
       top: 145px;
 
       top: 145px;
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       width: 200px;
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       width:60%;
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      height: 200px;
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  height:1000px;
 
       background: url(https://static.igem.org/mediawiki/2018/4/41/T--CPU_CHINA--background-carriage.png);
 
       background: url(https://static.igem.org/mediawiki/2018/4/41/T--CPU_CHINA--background-carriage.png);
−
      background-size: 150px 150px;
 
 
       background-repeat: no-repeat;
 
       background-repeat: no-repeat;
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       background-size: cover;  
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       background-size: 100%;  
 +
}
 +
.whole-carriage{
 +
display:block;
 +
position:relative;
 +
animation:mymove 5s;
 +
-webkit-animation:mymove 5s; /*Safari and Chrome*/
 
}
 
}
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</style>
 
  
−
<body>
 
  
−
<!--*******************************************头部代码***************************************-->
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@keyframes mymove
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<div class="btn-group"  style="border:none;background-color:transparent;width: 100px;height:45px;position:relative;float:right;top: 60px;left: -70%;">
+
{
−
                <button type="button" data-toggle="dropdown" aria-haspopup="true" aria-expanded="false" style="border:none;background-color:transparent;width: 100%;height:45px;">
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from {left:0px;}
−
                </button>
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to {left:80%;}
−
                <ul class="dropdown-menu" style="background:url(https://static.igem.org/mediawiki/2018/d/d3/T--CPU_CHINA--dropdown1.png)">
+
}
−
                    <li style="margin-top:23px">  </li>
+
−
                    <li>
+
−
                        <a href="https://2018.igem.org/Team:CPU_CHINA/Background">Background</a>
+
−
                    </li>
+
−
                    <li>
+
−
                        <a href="https://2018.igem.org/Team:CPU_CHINA/Results">Results</a>
+
−
                    </li>
+
−
                    <li>
+
−
                        <a href="https://2018.igem.org/Team:CPU_CHINA/Experiments">Experiments</a>
+
−
                    </li>
+
−
                    <li>
+
−
                        <a href="https://2018.igem.org/Team:CPU_CHINA/Application">Application</a>
+
−
                    </li>
+
−
                    <li>
+
−
                        <a href="https://2018.igem.org/Team:CPU_CHINA/Part">Part</a>
+
−
                    </li>
+
−
                    <li>
+
−
                        <a href="https://2018.igem.org/Team:CPU_CHINA/Interlab">Interlab</a>
+
−
                    </li>
+
−
                </ul>
+
−
</div>
+
  
 +
@-webkit-keyframes mymove /*Safari and Chrome*/
 +
{
 +
from {left:0px;}
 +
to {left:80%;}
 +
}
  
−
            <div class="btn-group" style="border:none;background-color:transparent;width: 190px;height:45px;position:relative;float:right;top: 60px;left: -48%;">
+
  .anniu {
−
                <button type="button" data-toggle="dropdown" aria-haspopup="true" aria-expanded="false"style="border:none;background-color:transparent;width:100%;height:45px;">
+
      position: relative;
−
                </button>
+
      top: 42% !important;
−
                <ul class="dropdown-menu" style="background:url(https://static.igem.org/mediawiki/2018/4/4a/T--CPU_CHINA--dropdown2.png)">
+
      transition: top 0.2s;
−
                    <li style="margin-top:23px">  </li>
+
      margin: 0 0 0 -50px;
−
                    <li>
+
    }
−
                        <a href="https://2018.igem.org/Team:CPU_CHINA/HP/Silver">Silver HP</a>
+
−
                    </li>
+
−
                    <li>
+
−
                        <a href="https://2018.igem.org/Team:CPU_CHINA/HP/Gold_Integrated">Intergrated and Gold HP</a>
+
−
                    </li>
+
−
                    <li>
+
−
                        <a href="https://2018.igem.org/Team:CPU_CHINA/Engagement">Education and Public Engagement</a>
+
−
                    </li>
+
−
                </ul>
+
−
            </div>
+
  
 +
    .anniu>img {
 +
      height: 50px;
 +
    }
  
−
            <div class="btn-group"  style="border:none;background-color:transparent;width: 105px;height:45px;position:relative;float:right;top: 60px;left: -16%;">
+
    .anniu:hover {
−
              <button type="button" data-toggle="dropdown" aria-haspopup="true" aria-expanded="false"style="border:none;background-color:transparent;width:100%;height:45px;"></button>
+
      top: 90px;
−
             
+
    }
−
            </div>
+
  
−
            <div class="btn-group" style="border:none;background-color:transparent;width: 105px;height:45px;position:relative;float:right;top: 60px;left: 3%;">
+
</style>
−
                <button type="button" data-toggle="dropdown" aria-haspopup="true" aria-expanded="false" style="border:none;background-color:transparent;width:100%;height:45px;"></button>
+
−
                <ul class="dropdown-menu" style="background:url(https://static.igem.org/mediawiki/2018/a/a5/T--CPU_CHINA--dropdown3.png)">
+
−
                    <li style="margin-top:23px">  </li>
+
−
                    <li>
+
−
                        <a href="https://2018.igem.org/Team:CPU_CHINA/Notebook/Log">Log</a>
+
−
                    </li>
+
−
                    <li>
+
−
                        <a href="https://2018.igem.org/Team:CPU_CHINA/Safety">Safety</a>
+
−
                    </li>
+
−
                </ul>
+
−
            </div>
+
  
−
            <div class="btn-group" style="border:none;background-color:transparent;width: 95px;height:45px;position:relative;float:right;top: 60px;left: 20%;">
+
 
−
                <button type="button" data-toggle="dropdown" aria-haspopup="true" aria-expanded="false" style="border:none;background-color:transparent;width:100%;height:45px;"></button>
+
<body background="img/bgd7.png">
−
                <ul class="dropdown-menu" style="background:url(https://static.igem.org/mediawiki/2018/c/c5/T--CPU_CHINA--dropdown4.png)">
+
−
                    <li style="margin-top:23px">  </li>
+
−
                    <li>
+
−
                        <a href="https://2018.igem.org/Team:CPU_CHINA/Notebook">Team</a>
+
−
                    </li>
+
−
                    <li>
+
−
                        <a href="https://2018.igem.org/Team:CPU_CHINA/Attributions">Attributions</a>
+
−
                    </li>
+
−
                    <li>
+
−
                        <a href="https://2018.igem.org/Team:CPU_CHINA/Collarations">Collaborations</a>
+
−
                    </li>
+
−
                </ul>
+
−
            </div>
+
  
 
<!-- *******************************************临时文字********************************************-->         
 
<!-- *******************************************临时文字********************************************-->         
−
<div id="title" style="font-size:23px;color:black;text-align:center;position:relative;top:190px;">
+
<!-- <div id="title" style="font-size:23px;color:black;text-align:center;position:relative;top:190px;">
 
A gene therapy strategy to traget hepatocellular carcinoma based on conditional RNA interference
 
A gene therapy strategy to traget hepatocellular carcinoma based on conditional RNA interference
−
</div>
+
</div> -->
−
 
+
−
<div style="inline-height:50px;position:relative;color:black;overflow:hidden;font-size;20px;top:230px;" id="introduction">
+
−
    Hepatocellular carcinoma (HCC), also called malignant hepatoma, is one of the deadliest cancers. Through the introduction of a double-stranded RNA to the targeted messenger RNA (mRNA), RNA interference (RNAi) leads to the specific cleavage of the mRNA and efficient silencing of gene expression. Since RNAi could be used to silence genes involved in the development and progression of carcinomas, it has promising therapeutic potential for their treatment. The gene therapy strategy we propose here:
+
−
(1) utilize two cancer-specific promoters (one HCC-specific) to open an AND-gated system to target HCC, the selectivity supposed to be extremely high;
+
−
(2) is dependent on and hence controllable by a low molecular weight compound;
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−
(3) has the flexibility to be adapted to target any mRNA and, if there are disease-specific promoters, other diseases.
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−
</div>
+
−
 
+
−
<div style="position:relative;top:280px;font-size:16px;color:black;" id="href">
+
−
More relevant background information can be seen in <a href="/Team:CPU_CHINA/Background">Background</a>
+
−
<div>
+
  
 
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<!-- *****************************************马车动画*********************************************-->
−
<div class="box" id="box">
+
<video id="home-video" style="position:absolute;width:70%;margin-left:15%;top:11%;z-index:100;display:none;" controls="controls" loop="false" preload="preload">
−
  <div class="carriage">
+
    <source src="https://static.igem.org/mediawiki/2018/5/58/T--CPU_CHINA--home-video.mp3" type="video/mp3"/>
−
  </div>
+
    <source src="https://static.igem.org/mediawiki/2018/b/be/T--CPU_CHINA--team-video2.mp4" type="video/mp4"/>
 +
    <source src="https://static.igem.org/mediawiki/2018/f/ff/T--CPU_CHINA--team-video3.webm" type="video/webm"/>
 +
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 +
</video>
 +
<div id="whole-carriage" class="whole-carriage">
 +
<div class="carriage" id="carriage">
 +
</div>
  
−
  <div class="wheel">
+
<div class="wheel" id="wheel1">
−
  </div>
+
</div>
  
−
  <!--
+
<div class="wheel" id="wheel2" style="margin-left:26%">
−
  <div class="carriage" style="top:370px;left:90%;">
+
</div>
−
  </div>
+
</div>
  
−
  <div class="wheel" style="top:550px;left:95%;">
+
<div id="anniu1" class="anniu" style="top:150px;">
−
  </div>
+
      <center>
−
  -->
+
            <a href="#words">
 +
              <img style="width:20%" src="https://static.igem.org/mediawiki/2018/6/65/T--CPU_CHINA--gold.jpg">
 +
            </a>
 +
      </center>
 
</div>
 
</div>
  
  
 +
<div id="words" style="position:relative;display:none;width:80%;top:43%;margin-left:10%;font-size:2.2rem;line-height:2.5;">
 +
<h1 style="position:relative;width:90%;margin-left:5%;top:28%;text-align:center;">A gene therapy strategy to target hepatocellular carcinoma based on conditional RNA interference</h1>
 +
  <h4 style="font-size:2rem;line-height:2">A microRNA is a short non-coding RNA that has the ability to target mRNA, to mediate its degradation and to regulate gene expression at post-transcriptional level. This post-transcriptional gene silencing (also known as RNA interference) proved widely applicable in gene therapy, albeit with undesirable effects due to low specificity. Mature miRNA is processed form the primary transcript pri-miRNA, therefore an “AND” gate system could be built based on specific structural properties that define pri-miRNAs, in order to improve such specificity. We then also managed to engineer disease-specific promoters and RNA-dependent RNA polymerase to process the logic information. CPU_CHINA focused on hepatocellular carcinoma (HCC) as the disease-therapeutic setting to be applied on with this strategy. But the concept definitely possesses the flexibility that can be discussed over other disease settings and the corresponding necessary gene therapy, which supports a New Application of Genetically Engineered Machine.</h4>   
 +
</div>
 +
 +
<img class="footer" src="https://static.igem.org/mediawiki/2018/c/c9/T--CPU_CHINA--footer2.png" style="width:100%"/>
 
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$(document).ready(function(){
 
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−
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+
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−
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+
−
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+
−
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+
−
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+
−
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+
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+
 
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     $(".mw-content-ltr").css("width",$(window).width()+"px");
−
     $(".mw-content-ltr").css("height",document.body.scrollHeight+"px");
+
     $(".mw-content-ltr").css("height",document.body.scrollHeight+500+"px");
−
 
+
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+
 
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   parent.appendChild(child);
 
   parent.appendChild(child);
 
}
 
}
 +
 +
$(document).ready(function(){
 +
//$(".whole-carriage").css("animation","mymove 7s");
 +
//$(".whole-carriage").css("-webkit-animation","mymove 7s");
 +
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 +
 +
//var e = document.getElementById("whole-carriage");
 +
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 +
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 +
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 +
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 +
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 +
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Latest revision as of 04:04, 8 December 2018