Difference between revisions of "Team:CPU CHINA"

 
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<link rel="stylesheet" href="https://2018.igem.org/Team:CPU_CHINA/bootstrap_style_css?action=raw&ctype=text/css">
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<div style="inline-height:50px;position:relative;color:black;overflow:hidden;font-size;20px;top:230px;" id="introduction">
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     Hepatocellular carcinoma (HCC), also called malignant hepatoma, is one of the deadliest cancers. Through the introduction of a double-stranded RNA to the targeted messenger RNA (mRNA), RNA interference (RNAi) leads to the specific cleavage of the mRNA and efficient silencing of gene expression. Since RNAi could be used to silence genes involved in the development and progression of carcinomas, it has promising therapeutic potential for their treatment. The gene therapy strategy we propose here:
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(1) utilize two cancer-specific promoters (one HCC-specific) to open an AND-gated system to target HCC, the selectivity supposed to be extremely high;
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     <source src="https://static.igem.org/mediawiki/2018/5/58/T--CPU_CHINA--home-video.mp3" type="video/mp3"/>
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(2) is dependent on and hence controllable by a low molecular weight compound;
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    <source src="https://static.igem.org/mediawiki/2018/b/be/T--CPU_CHINA--team-video2.mp4" type="video/mp4"/>
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(3) has the flexibility to be adapted to target any mRNA and, if there are disease-specific promoters, other diseases.
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<div style="position:relative;top:280px;font-size:16px;color:black;" id="href">
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More relevant background information can be seen in <a href="/Team:CPU_CHINA/Background">Background</a>
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      <center>
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            <a href="#words">
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              <img style="width:20%" src="https://static.igem.org/mediawiki/2018/6/65/T--CPU_CHINA--gold.jpg">
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<div id="words" style="position:relative;display:none;width:80%;top:43%;margin-left:10%;font-size:2.2rem;line-height:2.5;">
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<h1 style="position:relative;width:90%;margin-left:5%;top:28%;text-align:center;">A gene therapy strategy to target hepatocellular carcinoma based on conditional RNA interference</h1>
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  <h4 style="font-size:2rem;line-height:2">A microRNA is a short non-coding RNA that has the ability to target mRNA, to mediate its degradation and to regulate gene expression at post-transcriptional level. This post-transcriptional gene silencing (also known as RNA interference) proved widely applicable in gene therapy, albeit with undesirable effects due to low specificity. Mature miRNA is processed form the primary transcript pri-miRNA, therefore an “AND” gate system could be built based on specific structural properties that define pri-miRNAs, in order to improve such specificity. We then also managed to engineer disease-specific promoters and RNA-dependent RNA polymerase to process the logic information. CPU_CHINA focused on hepatocellular carcinoma (HCC) as the disease-therapeutic setting to be applied on with this strategy. But the concept definitely possesses the flexibility that can be discussed over other disease settings and the corresponding necessary gene therapy, which supports a New Application of Genetically Engineered Machine.</h4>   
 
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Latest revision as of 04:04, 8 December 2018