Difference between revisions of "Team:UAlberta"

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<h1> Welcome to iGEM 2018! </h1>
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    <div class="ua-home">
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<p>Your team has been approved and you are ready to start the iGEM season! </p>
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      <div class="ua-home-section">
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        <div class="ua-stripes">
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          <span></span>
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        <div class="ua-navbar">
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<h3>Before you start</h3>
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          <nav class="navbar fixed-top navbar-expand-lg navbar-dark">
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<p> Please read the following pages:</p>
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            <div class="container">
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<ul>
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              <a class="navbar-brand" href="https://2018.igem.org/Team:UAlberta"><img class="ua-navbar-brand" src="https://static.igem.org/mediawiki/2018/2/21/T--UAlberta--LogoHeaderWhite.svg" /></a>
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<li>  <a href="https://2018.igem.org/Competition">Competition Hub</a> </li>
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              <button class="navbar-toggler" type="button" data-toggle="collapse" data-target="#navbarSupportedContent"
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<li> <a href="https://2018.igem.org/Competition/Deliverables/Wiki">Wiki Requirements page</a></li>
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                aria-controls="navbarSupportedContent" aria-expanded="false" aria-label="Toggle navigation">
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<li> <a href="https://2018.igem.org/Resources/Template_Documentation">Template documentation</a></li>
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                <span class="navbar-toggler-icon"></span>
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              </button>
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          <ul class="navbar-nav ml-auto">
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            <li class="nav-item dropdown">
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              <a class="nav-link dropdown-toggle" href="https://2018.igem.org/Team:UAlberta" id="navbarDropdown" role="button" data-toggle="dropdown"
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                aria-haspopup="true" aria-expanded="false">
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                Project
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              </a>
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              <div class="dropdown-menu" aria-labelledby="navbarDropdown">
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                <a class="dropdown-item" href="https://2018.igem.org/Team:UAlberta/Description">Description</a>
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                <a class="dropdown-item" href="https://2018.igem.org/Team:UAlberta/Design">Design</a>
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                <a class="dropdown-item" href="https://2018.igem.org/Team:UAlberta/Results">Results</a>
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                <a class="dropdown-item" href="https://2018.igem.org/Team:UAlberta/Demonstrate">Demonstrate</a>
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<a class="dropdown-item" href="https://2018.igem.org/Team:UAlberta/BeeLab">BeeLab</a>
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                <a class="dropdown-item" href="https://2018.igem.org/Team:UAlberta/InterLab">InterLab</a>
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            <li class="nav-item dropdown">
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              <a class="nav-link dropdown-toggle" href="#" id="navbarDropdown" role="button" data-toggle="dropdown"
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                Parts
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              </a>
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              <div class="dropdown-menu" aria-labelledby="navbarDropdown">   
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                <a class="dropdown-item" href="https://2018.igem.org/Team:UAlberta/Parts">Overview</a>
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                <a class="dropdown-item" href="https://2018.igem.org/Team:UAlberta/Improve">Improve</a>
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            <li class="nav-item dropdown">
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              <a class="nav-link dropdown-toggle" href="#" id="navbarDropdown" role="button" data-toggle="dropdown"
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                aria-haspopup="true" aria-expanded="false">
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                Human Practices
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              </a>
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              <div class="dropdown-menu" aria-labelledby="navbarDropdown">
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                <a class="dropdown-item" href="https://2018.igem.org/Team:UAlberta/Human_Practices">Overview</a>
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                <a class="dropdown-item" href="https://2018.igem.org/Team:UAlberta/IntegratedHP">Integrated Human Practices</a>
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                <a class="dropdown-item" href="https://2018.igem.org/Team:UAlberta/Inclusivity">Inclusivity</a>
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                <a class="dropdown-item" href="https://2018.igem.org/Team:UAlberta/Public_Engagement">Public Engagement</a>
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              </div>
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            </li>
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            <li class="nav-item dropdown">
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              <a class="nav-link dropdown-toggle" href="#" id="navbarDropdown" role="button" data-toggle="dropdown"
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                aria-haspopup="true" aria-expanded="false">
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                Notebook
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              </a>
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              <div class="dropdown-menu" aria-labelledby="navbarDropdown">
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                <a class="dropdown-item" href="https://2018.igem.org/Team:UAlberta/Notebook">Lab Notebook</a>
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                <a class="dropdown-item" href="https://2018.igem.org/Team:UAlberta/Protocols">Protocols</a>
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                <a class="dropdown-item" href="https://2018.igem.org/Team:UAlberta/Safety">Safety</a>
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            <li class="nav-item dropdown">
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              <a class="nav-link dropdown-toggle" href="#" id="navbarDropdown" role="button" data-toggle="dropdown"
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                aria-haspopup="true" aria-expanded="false">
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                Team
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              </a>
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              <div class="dropdown-menu" aria-labelledby="navbarDropdown">
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                <a class="dropdown-item" href="https://2018.igem.org/Team:UAlberta/Team">Members</a>
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                <a class="dropdown-item" href="https://2018.igem.org/Team:UAlberta/Collaborations">Collaboration</a>
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                <a class="dropdown-item" href="https://2018.igem.org/Team:UAlberta/Attributions">Attribution</a>
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                <a class="dropdown-item" href="https://2018.igem.org/Team:UAlberta/Awards">Awards</a>
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                <a class="dropdown-item" href="https://2018.igem.org/Team:UAlberta/Sponsors">Sponsors</a>
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              </div>
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            </li>
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          </ul>
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              <div class="col-lg-6 col-md-10">
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                <strong><h1>Combatting <i>Nosema</i> infections in honeybees with an Antifungal Porphyrin-based Intervention
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System (APIS)</h1></strong>
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                <p>Team UAlberta’s project aims to solve an impending threat to Alberta’s apiculture industry.</p>
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                <button onclick="location.href='https://2018.igem.org/Team:UAlberta/Description'" type="button" class="btn btn-info btn-lg">Learn more</button>
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                <img src="https://static.igem.org/mediawiki/2018/7/7f/T--UAlberta--PorphyrinandBeeSchematic.svg" alt="" width="800px" height="600px" />
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          <div class="ua-porphyrin d-none d-lg-block d-xl-none">
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            <img src="https://static.igem.org/mediawiki/2018/a/a7/T--UAlberta--PPIXSchematic.svg" alt="..." />
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          <div class="ua-porphyrin d-none d-lg-block d-xl-none">
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            <img src="https://static.igem.org/mediawiki/2018/a/a7/T--UAlberta--PPIXSchematic.svg" alt="..." />
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          <div class="ua-porphyrin d-none d-lg-block d-xl-none">
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            <img src="https://static.igem.org/mediawiki/2018/a/a7/T--UAlberta--PPIXSchematic.svg" alt="..." />
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          <div class="ua-porphyrin d-none d-xl-block">
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            <img src="https://static.igem.org/mediawiki/2018/a/a7/T--UAlberta--PPIXSchematic.svg" alt="..." />
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          <div class="ua-porphyrin d-none d-xl-block">
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            <img src="https://static.igem.org/mediawiki/2018/a/a7/T--UAlberta--PPIXSchematic.svg" alt="..." />
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<div class="row align-items-center">
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<div class="col-2 d-none d-lg-block"></div>
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<div class="col-8 d-md-block">
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<h1>Achievements</h1>
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<h3><strong>Awarded</strong> Best Food & Nutrition Project Undergraduate</h3>
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<h3><strong>Nominated</strong> Best Integrated Human Practice Undergraduate</h3>
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<h3><strong>Awarded</strong> Gold Medal</h3>
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<p></p>
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<p></p>
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  <div class="col-2 d-none d-lg-block"></div>
 
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                <img class="ua-flipImage" src="https://static.igem.org/mediawiki/2018/c/ca/T--UAlberta--BeeSchematic.svg" alt="..." width="100%" height="auto" />
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              </div>
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              <div class="col-md-6 col-lg-6">
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                <p>Honeybees are <strong>integral</strong> to modern-day life as they contribute economically through honey production and they help maintain biodiversity by pollinating native species. However, honeybees are susceptible to various pathogens which can compound and cause colony failure. <i><strong>Nosema ceranae</strong></i> is one such pathogen.</p>
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                <p><i><strong>Nosema ceranae</strong></i> is a fungal parasite that can infect the midgut of Western honeybees (<i>Apis mellifera</i>). <i>Nosema</i> infections can cause higher mortality rates and can contribute to the death of entire hives. Issues with <i>Nosema</i> are heightened in cold areas like Alberta, Canada as its detrimental effects are aggravated by cold climates.</p>
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              <div class="col-md-6 col-lg-4 d-none d-md-block">
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                <img src="https://static.igem.org/mediawiki/2018/3/3e/T--UAlberta--NosemaSchematic.svg" alt="..." width="100%" height="auto" />
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                <img src="https://static.igem.org/mediawiki/2018/2/20/T--UAlberta--FumagillinSchematic.svg" alt="..." width="100%" height="auto" />
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                <p>The severity of <i>Nosema</i> and its impacts in Alberta has increased this year as the only treatment available for <i>Nosema</i>, a fungicide called <strong>fumagillin</strong>, has been <strong>discontinued</strong>. Team UAlberta discovered this issue after speaking with members of the beekeeping community who expressed the desparate need for a fumagillin alternative. Thus, Team UAlberta’s objective was to develop a solution that would address the loss of fumagillin.</p>
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            <h1>The Big Picture</h1>
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            <p>Building off of information collected from our interviews with stakeholders in the beekeeping community and consulting published literature, we developed <strong>APIS: an Antifungal Porphyrin-based Intervention System</strong> for treating <i>Nosema</i> infections in honeybees.  APIS aims to use engineered <i>Escherichia coli</i> to overproduce molecules, called <strong>porphyrins</strong>, which has been shown to damage <i>Nosema</i> spores. As a result, APIS presents a potential replacement for traditional fungicides and can be used as a preventative measure and treatment for <i>Nosema</i> infections.</p>
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<img src="https://static.igem.org/mediawiki/2018/6/65/T--UAlberta--OverviewNew.png" alt="..." width="100%" height="auto" />
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<h3> Styling your wiki </h3>
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<p>You may style this page as you like or you can simply leave the style as it is. You can easily keep the styling and edit the content of these default wiki pages with your project information and completely fulfill the requirement to document your project.</p>
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<p>While you may not win Best Wiki with this styling, your team is still eligible for all other awards. This default wiki meets the requirements, it improves navigability and ease of use for visitors, and you should not feel it is necessary to style beyond what has been provided.</p>
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<p>When you upload, set the "Destination Filename" to <b> T--YourOfficialTeamName--NameOfFile.jpg</b>. (If you don't do this, someone else might upload a different file with the same "Destination Filename", and your file would be erased!)</p>
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<p>We have created these wiki template pages to help you get started and to help you think about how your team will be evaluated. You can find a list of all the pages tied to awards here at the <a href="https://2018.igem.org/Judging/Pages_for_Awards">Pages for awards</a> link. You must edit these pages to be evaluated for medals and awards, but ultimately the design, layout, style and all other elements of your team wiki is up to you!</p>
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<li>Start documenting your project as early as possible; don’t leave anything to the last minute before the Wiki Freeze. For a complete list of deadlines visit the <a href="https://2018.igem.org/Calendar">iGEM 2018 calendar</a> </li>
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<li> <a href="https://2014.igem.org/Team:Aalto-Helsinki">2014 Aalto-Helsinki</a> </li>
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<li> <a href="https://2014.igem.org/Team:LMU-Munich">2014 LMU-Munich</a> </li>
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<li> <a href="https://2014.igem.org/Team:Michigan"> 2014 Michigan</a></li>
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<li> <a href="https://2014.igem.org/Team:ITESM-Guadalajara">2014 ITESM-Guadalajara </a></li>
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Latest revision as of 04:41, 8 December 2018

Combatting Nosema infections in honeybees with an Antifungal Porphyrin-based Intervention System (APIS)

Team UAlberta’s project aims to solve an impending threat to Alberta’s apiculture industry.

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Achievements

Awarded Best Food & Nutrition Project Undergraduate

Nominated Best Integrated Human Practice Undergraduate

Awarded Gold Medal

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Honeybees are integral to modern-day life as they contribute economically through honey production and they help maintain biodiversity by pollinating native species. However, honeybees are susceptible to various pathogens which can compound and cause colony failure. Nosema ceranae is one such pathogen.

Nosema ceranae is a fungal parasite that can infect the midgut of Western honeybees (Apis mellifera). Nosema infections can cause higher mortality rates and can contribute to the death of entire hives. Issues with Nosema are heightened in cold areas like Alberta, Canada as its detrimental effects are aggravated by cold climates.

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The severity of Nosema and its impacts in Alberta has increased this year as the only treatment available for Nosema, a fungicide called fumagillin, has been discontinued. Team UAlberta discovered this issue after speaking with members of the beekeeping community who expressed the desparate need for a fumagillin alternative. Thus, Team UAlberta’s objective was to develop a solution that would address the loss of fumagillin.

The Big Picture

Building off of information collected from our interviews with stakeholders in the beekeeping community and consulting published literature, we developed APIS: an Antifungal Porphyrin-based Intervention System for treating Nosema infections in honeybees. APIS aims to use engineered Escherichia coli to overproduce molecules, called porphyrins, which has been shown to damage Nosema spores. As a result, APIS presents a potential replacement for traditional fungicides and can be used as a preventative measure and treatment for Nosema infections.

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