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<h2 style="width:70%;margin-left:15%">Molecular Dynamic Simulations</h2> | <h2 style="width:70%;margin-left:15%">Molecular Dynamic Simulations</h2> | ||
<p style="width:70%;margin-left:15%"> | <p style="width:70%;margin-left:15%"> | ||
− | One of our constructs relied on linkers of sufficient length and flexibility to convert a conformational change, into signal transduction. We have achieved this through firstly modeling with PyMol [[[[LINK TO LINKER DEVELOPMENT TAB]]] and then performing molecular dynamic simulations of the root-mean-square deviation of atomic position [[[LINK TO Molecular Dynamics Tab]]]]. | + | One of our constructs relied on linkers of sufficient length and flexibility to convert a conformational change, into signal transduction. We have achieved this through firstly modeling with PyMol [[[[LINK TO LINKER DEVELOPMENT TAB]]] |
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+ | <figure style="width:70%;margin-left:15%"> | ||
+ | <img src="https://static.igem.org/mediawiki/2018/b/b6/T--Queens_Canada--PyMOLNoLinker.jpg" alt='nolinker'/> | ||
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+ | and then performing molecular dynamic simulations of the root-mean-square deviation of atomic position [[[LINK TO Molecular Dynamics Tab]]]]. | ||
<figure style="width:70%;margin-left:15%"> | <figure style="width:70%;margin-left:15%"> | ||
<img src="https://static.igem.org/mediawiki/2018/f/f7/T--Queens_Canada--RMSDcartoon0.png" alt='RMSD0'/> | <img src="https://static.igem.org/mediawiki/2018/f/f7/T--Queens_Canada--RMSDcartoon0.png" alt='RMSD0'/> |
Revision as of 02:18, 11 October 2018
At team Queens Canada, we believe that proper preparation is the best way to reach a desired outcome. Accordingly, we sought to model many aspects of our project which aided in making the right choices in the lab and receiving positive results. Through the help of student on our team specializing in biomedical computing, applied mathematics, and chemical engineering, we created a number of different models that were crucial to our project design.
Molecular Dynamic Simulations
One of our constructs relied on linkers of sufficient length and flexibility to convert a conformational change, into signal transduction. We have achieved this through firstly modeling with PyMol [[[[LINK TO LINKER DEVELOPMENT TAB]]]