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Revision as of 16:47, 13 October 2018
![](https://static.igem.org/mediawiki/2018/8/88/T--Queens_Canada--ellis_header.jpeg)
Laboratory
To develop a biosensor, we took two design approaches. At the core of both approaches is a modular Nuclear Receptor Ligand binding domain for binding to an analyte. Immediately flanking the ligand binding domain was two linkers of 3-11 amino acids in length, the selection of appropriate linkers was aided by extensive in-silico modelling((((LINK)))), and root-mean-square deviation molecular dynamic modelling(((((LINK))))). On the ends of each linker was our signal transduction system which acts as our method of producing a measurable outcome once a ligand has bound the receptor.