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<h3>Pri-miRNA</h3> | <h3>Pri-miRNA</h3> | ||
− | MiRNAs are a group of short non-coding RNAs that mediate post-transcriptional gene silencing (PTGS) .Binding of a miRNA to its target mRNA mediates mRNA degradation and blocks translation.MiRNA biogenesis initiates with the transcription of the pri‑miRNA. General domains of a pri-miRNA is shown on the right. These long pri‑miRNAs are then cleaved by Microprocessor, which comprises the double‑stranded RNase III enzyme DROSHA and its essential cofactor, the double‑stranded RNA (dsRNA)‑binding protein DiGeorge syndrome critical region 8 (DGCR8). DROSHA requires long single-stranded regions flanking the short hairpin structure in its substrates. If the basal ssRNA is somehow blocked, the cleavage reaction would also be blocked. | + | MiRNAs are a group of short non-coding RNAs that mediate post-transcriptional gene silencing (PTGS). Binding of a miRNA to its target mRNA mediates mRNA degradation and blocks translation. MiRNA biogenesis initiates with the transcription of the pri‑miRNA. General domains of a pri-miRNA is shown on the right. These long pri‑miRNAs are then cleaved by Microprocessor, which comprises the double‑stranded RNase III enzyme DROSHA and its essential cofactor, the double‑stranded RNA (dsRNA)‑binding protein DiGeorge syndrome critical region 8 (DGCR8). DROSHA requires long single-stranded regions flanking the short hairpin structure in its substrates. If the basal ssRNA is somehow blocked, the cleavage reaction would also be blocked. |
*For more information, please see <a class="ref" id="r1">Reference(1)</a>. The figure General domains of a pri-miRNA and Schematic diagram of the base-anchor model come from <a class="ref" id="r2">Reference (2)</a> and<a class="ref" id="r3">(3)</a>. | *For more information, please see <a class="ref" id="r1">Reference(1)</a>. The figure General domains of a pri-miRNA and Schematic diagram of the base-anchor model come from <a class="ref" id="r2">Reference (2)</a> and<a class="ref" id="r3">(3)</a>. | ||
Revision as of 12:41, 6 June 2018