Difference between revisions of "Team:UST Beijing/Background"

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             <p><span>atherosclerosis</span></p>
 
             <p><span>atherosclerosis</span></p>
 
             <h1><span> An alarming health threat: Atherosclerosis</span></h1>
 
             <h1><span> An alarming health threat: Atherosclerosis</span></h1>
             <p>Here are the cholesterol structure and pie chart of Epidemic statisitcs of atherosclerosis-related mortality in China</p>
+
             <p>Shown on the right are the cholesterol structure and pie charts of Epidemic statistics of atherosclerosis-related mortality in China</p>
 
           </blockquote>
 
           </blockquote>
 
         </div>
 
         </div>
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       <div class="span4">
 
       <div class="span4">
 
         <h2><span>Pathology of Atheroscleosis</span></h2>
 
         <h2><span>Pathology of Atheroscleosis</span></h2>
         <p>Artery atherosclerosis refers to arteries accumulated with cholesterol resulting in blockage of blood flow. Cholesterol is the main culprit of cardio-cerebrovascular disease. In heart it results in heart attack. In brain it results in blockage stroke.</p>
+
         <p>Artery atherosclerosis refers to arteries accumulated with cholesterol resulting in blockage of blood flow. Cholesterol is the main culprit of cardio-cerebrovascular disease. In heart it causes heart attack. In brain it causes blockage stroke.</p>
 
         <div class="pad15"></div>
 
         <div class="pad15"></div>
 
         <div class="hover_colour"> <a href="https://static.igem.org/mediawiki/2018/b/b0/T--UST_Beijing--bg10.jpg" data-rel="prettyPhoto[portfolio1]"> <img src="https://static.igem.org/mediawiki/2018/7/75/T--UST_Beijing--bg5.jpg" alt="" /></a> </div>
 
         <div class="hover_colour"> <a href="https://static.igem.org/mediawiki/2018/b/b0/T--UST_Beijing--bg10.jpg" data-rel="prettyPhoto[portfolio1]"> <img src="https://static.igem.org/mediawiki/2018/7/75/T--UST_Beijing--bg5.jpg" alt="" /></a> </div>
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       <div class="span4">
 
       <div class="span4">
 
         <h2><span>Molecular Mechanism of Atherosclerosis Formation</span></h2>
 
         <h2><span>Molecular Mechanism of Atherosclerosis Formation</span></h2>
         <p>Because of cells’ apoptosis caused by foam cell, which is reversed from macrophages overloading cholesterol, the deposition of cholesterol is formed.</p>
+
         <p>Because of foam cell apoptosis, which is formed by macrophages overloading cholesterol, cholesterol is deposited on the inner wall of artery.</p>
 
         <div class="pad15"></div>
 
         <div class="pad15"></div>
 
         <div class="hover_colour"> <a href="https://static.igem.org/mediawiki/2018/e/ed/T--UST_Beijing--bg8.jpg" data-rel="prettyPhoto[portfolio1]"> <img src="https://static.igem.org/mediawiki/2018/5/5b/T--UST_Beijing--bg6.jpg" alt="" /></a> </div>
 
         <div class="hover_colour"> <a href="https://static.igem.org/mediawiki/2018/e/ed/T--UST_Beijing--bg8.jpg" data-rel="prettyPhoto[portfolio1]"> <img src="https://static.igem.org/mediawiki/2018/5/5b/T--UST_Beijing--bg6.jpg" alt="" /></a> </div>
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         <h2><span>Nuclear receptor LXR as therapeutic target against atherosclerosis</span></h2>
 
         <h2><span>Nuclear receptor LXR as therapeutic target against atherosclerosis</span></h2>
         <p>Live X receptor(LXR) functions as a significant regulation switch, which can accelerate the transport of cholesterol and prevent the formation of foam cells.</p>
+
         <p>Live X receptor(LXR) functions as a master regulation switch, which can accelerate the transport of cholesterol and prevent the formation of foam cells.</p>
 
         <div class="pad15"></div>
 
         <div class="pad15"></div>
 
         <div class="hover_colour"> <a href="https://static.igem.org/mediawiki/2018/4/4d/T--UST_Beijing--bg9.jpg" data-rel="prettyPhoto[portfolio1]"> <img src="https://static.igem.org/mediawiki/2018/f/fc/T--UST_Beijing--bg7.jpg" alt="" /></a> </div>
 
         <div class="hover_colour"> <a href="https://static.igem.org/mediawiki/2018/4/4d/T--UST_Beijing--bg9.jpg" data-rel="prettyPhoto[portfolio1]"> <img src="https://static.igem.org/mediawiki/2018/f/fc/T--UST_Beijing--bg7.jpg" alt="" /></a> </div>
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  <div class="row">
  <blockquote><p>Ginseng sapogenin’s structure is similar to that of cholesterol, that is to say, it has the potential of regulating LXRs.
+
  <blockquote><p>Ginseng triterpenes' structure is similar to that of cholesterol, that is to say, it has the potential of regulating LXRs.
       LXRs has a typical nuclear receptor structure. In the existence of coactivators, regulated by agonists (such as ginsenoside), LXRs could combine the special site in gene promoter region to repress or active the transcripstion of the target gene.
+
       LXRs is a typical nuclear receptor. In the presence of co-activators, regulated by agonists (such as ginsenoside), LXRs could binds
       So to sum up, ginsenoside could regulate the metabolism of cholesterol. We devote to finding a better way to solve the two remaining problems.
+
special site on target gene promoter region to repress or active the transcription of the target gene.
 +
       So to sum up, ginsenosides could regulate the metabolism of cholesterol. We devote to finding a better way to solve the two remaining problems.
 
     Here is the foothold of our project postulates.</p></blockquote>
 
     Here is the foothold of our project postulates.</p></blockquote>
 
  </div>
 
  </div>

Revision as of 00:57, 11 October 2018

Team:UST_Beijing/Collaborations

Cholesterol

an essential component of membrane structure, but gradually accumulates in arteries of human body, which results in the number one killer mechanism of human life:

atherosclerosis

An alarming health threat: Atherosclerosis

Shown on the right are the cholesterol structure and pie charts of Epidemic statistics of atherosclerosis-related mortality in China

Pathology of Atheroscleosis

Artery atherosclerosis refers to arteries accumulated with cholesterol resulting in blockage of blood flow. Cholesterol is the main culprit of cardio-cerebrovascular disease. In heart it causes heart attack. In brain it causes blockage stroke.

Molecular Mechanism of Atherosclerosis Formation

Because of foam cell apoptosis, which is formed by macrophages overloading cholesterol, cholesterol is deposited on the inner wall of artery.

Nuclear receptor LXR as therapeutic target against atherosclerosis

Live X receptor(LXR) functions as a master regulation switch, which can accelerate the transport of cholesterol and prevent the formation of foam cells.

Ginseng triterpenes' structure is similar to that of cholesterol, that is to say, it has the potential of regulating LXRs. LXRs is a typical nuclear receptor. In the presence of co-activators, regulated by agonists (such as ginsenoside), LXRs could binds special site on target gene promoter region to repress or active the transcription of the target gene. So to sum up, ginsenosides could regulate the metabolism of cholesterol. We devote to finding a better way to solve the two remaining problems. Here is the foothold of our project postulates.

Ginsenoside TR1 modulates
LXR biological activity

Atherosclerosis formation is delayed
by ginsenosides in vivo