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<h2 style="width:70%;margin-left:15%">Molecular Dynamic Simulations</h2> | <h2 style="width:70%;margin-left:15%">Molecular Dynamic Simulations</h2> | ||
<p style="width:70%;margin-left:15%"> | <p style="width:70%;margin-left:15%"> | ||
− | One of our constructs relied on linkers of sufficient length and flexibility to convert a conformational change, into signal transduction. We have achieved this through firstly modeling with <a href="https://2018.igem.org/Team:Queens_Canada/Linker_Development">PyMol</a> and then performing molecular dynamic simulations of the root-mean-square deviation of <a href="https://2018.igem.org/Team:Queens_Canada/Fluid_Dynamics"> atomic position </a>. | + | One of our constructs relied on linkers of sufficient length and flexibility to convert a conformational change, into signal transduction. We have achieved this through firstly modeling with <a href="https://2018.igem.org/Team:Queens_Canada/Linker_Development">PyMol</a> and then performing molecular dynamic simulations of the root-mean-square deviation of <a href="https://2018.igem.org/Team:Queens_Canada/Fluid_Dynamics"> atomic position </a>. </p> |
<figure style="width:70%;margin-left:15%"> | <figure style="width:70%;margin-left:15%"> | ||
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<img src="https://static.igem.org/mediawiki/2018/f/f7/T--Queens_Canada--RMSDcartoon0.png" alt='RMSD0'/> | <img src="https://static.igem.org/mediawiki/2018/f/f7/T--Queens_Canada--RMSDcartoon0.png" alt='RMSD0'/> | ||
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<h3 style="width:70%;margin-left:15%">Michaelis - Menten kinetics</h3> | <h3 style="width:70%;margin-left:15%">Michaelis - Menten kinetics</h3> | ||
<p style="width:70%;margin-left:15%">Michaelis - Menten kinetics is a model used to examine enzyme kinetic. Luciferase's activity can be modeled by Michaelis-Menten kinetics as they perform the simple conversion of a substrate into a product and a photon. Our project relied on the light producing NanoLuc Luciferase as a signal in our devices. We were able to model this relationship with MATLAB. The governing equations | <p style="width:70%;margin-left:15%">Michaelis - Menten kinetics is a model used to examine enzyme kinetic. Luciferase's activity can be modeled by Michaelis-Menten kinetics as they perform the simple conversion of a substrate into a product and a photon. Our project relied on the light producing NanoLuc Luciferase as a signal in our devices. We were able to model this relationship with MATLAB. The governing equations |
Revision as of 01:13, 13 October 2018
At team Queens Canada, we believe that proper preparation is the best way to reach a desired outcome. Accordingly, we sought to model many aspects of our project which aided in making the right choices in the lab and receiving positive results. Through the help of student on our team specializing in biomedical computing, applied mathematics, and chemical engineering, we created a number of different models that were crucial to our project design.
Molecular Dynamic Simulations
One of our constructs relied on linkers of sufficient length and flexibility to convert a conformational change, into signal transduction. We have achieved this through firstly modeling with PyMol and then performing molecular dynamic simulations of the root-mean-square deviation of atomic position .