Expert Interviews

Dr. Andrea Guerin
Department of Pediatrics, Queen’s University School of Medicine

Dr. Andrea Guerin is a full time Assistant Professor in Pediatrics and Medical Geneticist. She is the Year 2 Director at Queen’s University Medical School. Her work in Medical Genetics includes a consultation practice consisting of general genetics, prenatal genetics, cancer genetics and the care of patients with inborn errors of metabolism. Interviewing Dr. Guerin was a great opportunity to hear her thoughts on the pros, cons, and potential applications of using cortisol as a useful biomarker, including revelations on hypoglycemia, insulinemia, and early diagnosis of developmental disabilities. In terms of the pacifier model, she suggested potential use of a saliva collection device, which would work well as a non-invasive method of collecting DNA from infants to do genetic testing. As well, Dr. Guerin found value in the modular design of our ligand detection system and offered the potential of looking at glucose and bilirubin as other relevant metabolites in the pediatric field.

Dr. Kate Harkness
Department of Psychology, Queen’s University

Dr. Kate Harkness is Professor in the Department of Psychology and runs the Mood Research Lab at Queen’s University. She conducts research that primarily focuses on the correlation between stress and depression in adults and adolescents. Her studies focus on the effects of early childhood trauma on sensitizing the biological and psychological stress response in a manner that makes people more susceptible to psychopathology. She examines the changes in cortisol levels in response to stressors, and she pointed out several major factors that would contribute to the varying levels of cortisol in individuals raised in diverse settings. She suggested that our application should include a function to determine one’s personal cortisol baseline throughout different times of the day in order to give more meaning to the collected data. She believes our biosensor would be applicable to her line of research as it is a more time-efficient and non-disruptive method of monitoring cortisol levels in psychological studies.

Dr. Janet Menard
Department of Psychology, Queen’s University

Dr. Janet Menard is an Associate Professor in the Department of Psychology and runs the Neurobiology of Anxiety Lab at Queen’s University. Dr. Menard provided our team with lots of feedback on our project design and raised potential concerns that we must be aware of when designing our biosensor technology and the associated smartphone technology. She discussed the hyporesponsive stress period that occurs during the first year of one’s life, which provided an emphasis on the need to be able to effectively measure and determine a cortisol baseline for the app to work accurately for each user. She also discussed some of the concerns she had with the use of a genetically engineered protein being incorporated into the device. The appropriate safety testing and educational information must be readily accessible to all potential consumers to avoid any health and safety concerns. Our interview with Dr. Menard was very insightful and highlighted areas that our technology may be most useful for, with an emphasis on research and clinical settings. She believes the scientific community could benefit greatly from a cortisol-reading device that is fast, affordable and exceeds the accuracy of current devices on the market.

Dr. David Saleh
Department of Pediatrics, Queen’s University School of Medicine

Dr. David Saleh is a full time Assistant Professor in Pediatric Endocrinology and Metabolism for the Queen’s School of Medicine. His work at Hotel Dieu Hospital includes the full range of consultation in pediatric endocrinology including diabetes, growth/thyroid disorders, adrenal disorders and osteoporosis. Dr. Saleh was able to provide our team with extensive background knowledge on different metabolic disorders associated with adrenal insufficiency, as well as the current diagnostic procedures and treatments involved with these disorders. Based on personal experiences from Dr. Saleh’s line of work, he sees the need for non-invasive diagnostic systems for hormone-related disorders. As well, he suggested the use of our biosensor technology for use in monitoring the efficacy of various treatments, and to better track how the therapies or supplements are metabolized in an individual. Dr. Saleh was also able to provide our team with valuable information about the Ontario Newborn Screening process, and the endocrine-related disorders that are currently tested for -- offering insight into a potential future role for our technology as a less invasive screening method for newborns with metabolic disorders.

Dr. Kimberly Dow
Department of Pediatrics, Queen’s University School of Medicine

Dr. Kimberly Dow is a full time Professor of Pediatrics for the Queen’s School of Medicine and a neonatologist at Kingston General Hospital. She serves on both the Canadian Neonatal Network and Evidence Based Practice for Improving Quality (EPIQ) Steering Committees and is a member of the Board of Directors for the Canadian Pediatric Society. During our interview with Dr. Dow, we were able to gain valuable knowledge about daily procedures and processes that take place in Neonatal Intensive Care Units (NICU). By evaluating current practices involved in the maintenance of neonate well-being and pain-mitigation during different procedures, we were able to better understand how our project design could be implemented and beneficial in this setting. One of the specific applications that were elaborated on during our time with Dr. Dow was the use of our technology to aid in Newborn Abstinence Syndrome treatment plans and morphine dosage determination. The other application we discussed was the possibility of aiding with the use of sucrose as an analgesic for neonates, and determining the efficacy of this pain-reducing method that is currently employed. By creating a device that can quantify cortisol, stress and pain affecting non-verbal individuals can be better understood and managed to prevent detrimental developmental effects.

Dr. Harriet Feilotter
Department of Pathology and Molecular Medicine, Queen’s University

Dr. Harriet Feilotter is an Associate Professor in the Department of Pathology and Molecular Medicine at Queen’s University. Her research focuses on the development of biomarkers to be used in the screening, diagnosis and treatment of human diseases in clinical settings. Our meeting with Dr. Feilotter was very informative and provided a lot of insight into what research is required to validate our biosensor technology and demonstrate its effectiveness and clinical utility. She provided information pertaining to important parameters that must be evaluated when working with biomarkers, including analytic and clinical specificity and sensitivity values, negative and positive predictive values, the concentration range our technology can measure, the saturation point of our assay and cross-reactivity that might occur with molecules resembling cortisol. Dr. Feilotter was also very knowledgeable about the safety testing and potential experiments that may be useful in demonstrating the validity and safety of our device.