We used toehold switches that collapsed upon the binding of miRNAs, causing Cas13a to be transcribed, which would theoretically allow for a signal to be detected with the use of fluorescent probes.

Why is this important?

Whenever a disease process occurs in the human body, specialized miRNAs are released. Using these to cause the collapse of our toehold could allow for early detection of disease from blood samples.

Who are we? (insert photo of us here)

Pictures: our names and classes and majors

Tips

This wiki will be your team’s first interaction with the rest of the world, so here are a few tips to help you get started:

State your accomplishments! Tell people what you have achieved from the start.
Be clear about what you are doing and how you plan to do this.
You have a global audience! Consider the different backgrounds that your users come from.
Make sure information is easy to find; nothing should be more than 3 clicks away.
Avoid using very small fonts and low contrast colors; information should be easy to read.
Start documenting your project as early as possible; don’t leave anything to the last minute before the Wiki Freeze. For a complete list of deadlines visit the iGEM 2018 calendar
Have lots of fun!

Inspiration

You can also view other team wikis for inspiration! Here are some examples:

Team:Tufts

Tufts Team iGEM 2018!

What was our project?

Why is this important?

Who are we? (insert photo of us here)

Tips

Inspiration