We achieved our goal by applying a chemical reaction to hydrolyze ginsenosides and improved their bioavailability without compromising therapeutic values. Using mathematical models and published animal experiment data, we argued that our current approach would be safe and more efficacious than the common practice of ginsenosides usage methods.
The effective constituents of ginseng are glycosides and saponins. A set of data for the modeling of ginsenosideRb1, ginsenoside Rg1 and NotoginsenosideR1 referred to paper about Fufang Xueshuangtong.[1]
Three chemical compounds:
![](https://static.igem.org/mediawiki/2018/c/cc/T--UST_Beijing--modelpic1.jpg)
We use JDesigner (a visual biochemical network simulation tool) for the modeling below.
It can be seen from the structure that the three active ingredients can be converted by the loss or increase of free radicals, so we boldly assume a local circulation model to simulate the absorption of drugs into organisms.
Modeling for absorbing:
![](https://static.igem.org/mediawiki/2018/e/e5/T--UST_Beijing--modelpic2.jpg)
Curve of modeling:
![](https://static.igem.org/mediawiki/2018/c/c4/T--UST_Beijing--modelpic3.jpg)
The trend of the curve is similar to the experiment data.The following is the absorption of three saponins into the human body respectively.
Concentration in plasma of notoginsenosideR1:
a:Simulating by JDesigner
b:Experiment data
![](https://static.igem.org/mediawiki/2018/c/c4/T--UST_Beijing--modelpic4.jpg)
![](https://static.igem.org/mediawiki/2018/8/86/T--UST_Beijing--modelpic5.jpg)
Concentration in plasma of GinsenosideRg1
a:Simulating by JDesigner
b:Experiment data
![](https://static.igem.org/mediawiki/2018/b/bd/T--UST_Beijing--modelpic6.jpg)
![](https://static.igem.org/mediawiki/2018/3/34/T--UST_Beijing--modelpic7.jpg)
Concentration in plasma of GinsenosideRb1
a:Simulating by JDesigner
b:Experiment data
![](https://static.igem.org/mediawiki/2018/f/f8/T--UST_Beijing--modelpic8.jpg)
![](https://static.igem.org/mediawiki/2018/2/2b/T--UST_Beijing--modelpic9.jpg)