Difference between revisions of "Team:UST Beijing/Background"
| Line 117: | Line 117: | ||
<div class="pad45"></div> | <div class="pad45"></div> | ||
</div> | </div> | ||
| − | + | ||
| − | + | </div> | |
| − | + | <div class="row"> | |
| − | + | <div class="span6"> | |
<h2><span>Nuclear receptor LXR as therapeutic target against atherosclerosis</span></h2> | <h2><span>Nuclear receptor LXR as therapeutic target against atherosclerosis</span></h2> | ||
<h3>Live X receptor(LXR) functions as a master regulation switch, which can accelerate the transport of cholesterol and prevent the formation of foam cells.</h3> | <h3>Live X receptor(LXR) functions as a master regulation switch, which can accelerate the transport of cholesterol and prevent the formation of foam cells.</h3> | ||
| + | <div class="pad15"></div> | ||
<div class="hover_colour"> <a href="https://static.igem.org/mediawiki/2018/4/4d/T--UST_Beijing--bg9.jpg" data-rel="prettyPhoto[portfolio1]"> <img src="https://static.igem.org/mediawiki/2018/f/fc/T--UST_Beijing--bg7.jpg" alt="" /></a> </div> | <div class="hover_colour"> <a href="https://static.igem.org/mediawiki/2018/4/4d/T--UST_Beijing--bg9.jpg" data-rel="prettyPhoto[portfolio1]"> <img src="https://static.igem.org/mediawiki/2018/f/fc/T--UST_Beijing--bg7.jpg" alt="" /></a> </div> | ||
| − | + | </div> | |
| + | |||
<div class="span6 pad10"> | <div class="span6 pad10"> | ||
<h2><span>the Simulation of LXR </span></h2> | <h2><span>the Simulation of LXR </span></h2> | ||
| Line 137: | Line 139: | ||
<div class="row"> | <div class="row"> | ||
<h3>Ginseng triterpenes' structure is similar to that of cholesterol, therefore it has the potential of regulating LXRs. | <h3>Ginseng triterpenes' structure is similar to that of cholesterol, therefore it has the potential of regulating LXRs. | ||
| − | LXRs is a typical nuclear receptor. In the presence of co-regulators, bound by agonists (such as ginsenosides), LXRs could be demobilized to | + | LXRs is a typical nuclear receptor. In the presence of co-regulators, bound by agonists (such as ginsenosides), LXRs could be demobilized to specific site on a target gene promoter region to activate transcription of the target gene. Ginsenosides or like could therefore regulate the metabolism of cholesterol. </h3> |
</div> | </div> | ||
Revision as of 13:08, 16 October 2018
Cholesterol
an essential component of membrane structure, but gradually accumulates in arteries of human body, which becomes the top one killer mechanism of human life: atherosclerosis
An alarming health threat: Atherosclerosis
Shown on the right are the cholesterol structure and pie charts of epidemic statistics of atherosclerosis-related mortality in China (black area: atherosclerosis-related death).
Pathology of Atheroscleosis
Cholesterol is the main culprit of cardio-and cerebro-vascular disease. Artery atherosclerosis refers to arteries accumulated with cholesterol resulting in blockage of blood flow. In heart it causes heart attack. In brain it causes blockage stroke.
Molecular Mechanism of Atherosclerosis Formation
Because of foam cell apoptosis, which is formed by macrophages overloading cholesterol, cholesterol is deposited on the inner wall of artery.
Nuclear receptor LXR as therapeutic target against atherosclerosis
Live X receptor(LXR) functions as a master regulation switch, which can accelerate the transport of cholesterol and prevent the formation of foam cells.
the Simulation of LXR
LXRs has a typical nuclear receptor structure. In the existence of coactivators, regulated by agonists (such as ginsenoside), LXRs could combine the special site in gene promoter region to repress or active the transcripstion of the target gene.
Ginseng triterpenes' structure is similar to that of cholesterol, therefore it has the potential of regulating LXRs. LXRs is a typical nuclear receptor. In the presence of co-regulators, bound by agonists (such as ginsenosides), LXRs could be demobilized to specific site on a target gene promoter region to activate transcription of the target gene. Ginsenosides or like could therefore regulate the metabolism of cholesterol.
Ginsenoside TR1 modulates
LXR biological activity
